48 bone graft

Question 1

name the 5 growth factors named

Answer 1

TGF-b - all stages, multiple cells types
- BMP rhbmp 2 and 7
- absorbable collagen or calcium phosphate
FGF - early stages may enhance initiation
IGF - encourages cellular proliferation
PDGF - efficacy not shown.

Question 2

4 basic tenets of bone regeneration (OOOO)

Answer 2

osteogenesis
osteoinduction
osteoconduction
osteopromotion

Question 3

what is osteogenesis

Answer 3

provision bone forming cells

- eg autgoneous cancels bone graft

Question 4

what is osteoinduction

Answer 4

recruitment mesenchymal cells to infiltrate

- autogenous graft, DBM, BMP 2& 7

Question 5

what is osteoconduciton

Answer 5

provides scaffold for MSC’s to migrate and proliferate

DBM

Question 6

what is osteopromotion

Answer 6

enhance regeneration of bone

PRP hydrogels biphasic calcium phosphate

Question 7

which of the 4 tenets of bone regeneration is displayed be

1. autgenous bone graft
2. allograft based bone graft
3. DBM
4. cell based (MSC’s)

Answer 7

1. all 4
2. osteoinduction. osteoconduction
3. Osteoinduction, osteoconduction
4. osteogenesis

Question 8

what do BMP’s do

Answer 8

-drive differentiation of pluripotent stem cells to the osteoblastic lineage