465-476 FA

Question 1

Tight junction function

Answer 1

Prevent paracellular movement of solute, claudin and occludins.

Question 2

Zonula adherence

Answer 2

Connect Actin cytoskeleton of adjacent cells with cadherins

Question 3

Loss of E cadherin

Answer 3

Metastasis

Question 4

Desmosome another name, function

Answer 4

Maculla adherens

Structural support via intermediate filament interactions.

Question 5

Pemphigus vulgaris pathology

Answer 5

AutoAb to desmoglein 1 and 3

Question 6

What channel protein is in gap junction?

Answer 6

Connexon

Question 7

Connexon function

Answer 7

permit electrical and chemical communication Betwn cell

Question 8

Hemidesmosome function

Answer 8

Basal cell keratin with BM

Question 9

AutoAb to hemidesmosome.

Answer 9

bullous pemphigoid

Question 10

Integrity of BM maintained by

Answer 10

Integrins by bindibg to collagen, laminine and fibronectin

Question 11

Parakeratosis example

Answer 11

Psoriasis

Actinic keratosis

Question 12

Retention of nucleus in stratum corneum

Answer 12

Parakeratosis

Question 13

Increase thickness of stratum granulosum

Answer 13

Lichen planus( hypergranulosis)

Question 14

Acantholysis

Answer 14

Seperation of epidermal cell

Question 15

Acantholysis seen in

Answer 15

pemphigus V

Question 16

Acanthosis nigricans

Answer 16

Epidermal hyperplasia increased spinosum