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00000 Neurology > 434 Dementia with Lewy bodies > Flashcards

434 Dementia with Lewy bodies Flashcards

1
Q

Levy body disease can manifest as ____ and _____ diseases

A

PDD - Parkinson’s disease with Dementia

DLB - Dementia with Lewy Bodies

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2
Q

________ in LBD affects performance of ADLS beyond other PD symptoms

A

Cognitive decline in LBD affects performance of ADLS beyond other PD symptoms

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3
Q

Key neuropathologic features in LBD (2)

A
  • Lewy body
  • Lewy neurites
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4
Q

Intraneuronal cytoplasmic inclusions

A

Lewy body

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5
Q

Stains with PAS and ubiquitin

A

Lewy body

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6
Q

Why PDD and DLB are classified as SYNUCLEINOPATHIES

A

Due to the presence of alpha-synuclein aggregates in neurons and glia of PDD and DLB

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7
Q

Best predicts the clinical benefits and NOT the Lewy pathology per se (2)

A

Neuronal and Synaptic loss

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8
Q

3 Stages of Progression in DLB

A
  • Brainstem predominant
  • Transitional limbic
  • Diffuse neocortical
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9
Q

Usual start of PD (location)

A

Enteric nervous system

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10
Q

involved areas of the brain in Cholinergic vs Adrenergic deficit of DLB

A
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11
Q

Mutations of ________particularly lead to DLB or PDD presentations

A

Mutations of **GBA (glucocerebrosidase) **particularly lead to DLB or PDD presentations

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12
Q

7 biomarkers that can help distinguish LBD from AD

A
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13
Q

differentiate LBD from AD based on polysomnogram

A
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14
Q

differentiate LBD from AD based on CSF

A
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15
Q

differentiate LBD from AD based on MRI

A
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16
Q

differentiate LBD from AD based on PET SCAN (18F-deoxyglucose)

A
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17
Q

differentiate LBD from AD based on AMYLOID PET scan

A
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18
Q

differentiate LBD from AD based on MIBG myocardial scintigraphy

A
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19
Q

differentiate LBD from AD based on DAT scan or PET dopamine scan

A
20
Q

4 meds for symptomatic treatment of LBD

A
21
Q

Example of cholinesterase inhibitors as tx for LBD (2)

A
22
Q

Example of atypical antipsychotics that can be given for symptomtic tx of LBD

A
23
Q

Selective inverse agonist of serotonin 5-HT2a receptor that can be used for symptomatic tx of LBD

A
24
Q

Known side effect of Pimavenserin

A
25
Q

Known adverse effect of Clozapine

A
26
Q

Why are DLB patients should not be exposed to Neuroleptics

A
27
Q

Why are DLB patients should not be exposed to anticholinergics or dopamine agonists

A
28
Q

Treatment for RBD

A
29
Q

Alternative agents for tx of RBD if unresponsive to first line drug (3)

A
30
Q

Treatment for mood and anxiety symptoms in LBD

A
31
Q

Non pharmacologic tx for orthostatic hypotension in LBD (3)

A
32
Q

Pharmacologic tx for orthostatic hypotension in LBD (3)

A
33
Q

Differentiate DLB from AD based on MCI

A
34
Q

Differentiate DLB from AD based on frequency and severity of fluctuating cognition with variations in attention

A
35
Q

Differentiate DLB from AD based on SLEEP

A
36
Q

Differentiate DLB from AD based on frequency recurrent visual hallucinations

A
37
Q

Main diagnostic features of DLB (5)

A
38
Q

Dementia and neuropsychiatric symptoms precede or co-emerge with the parkinsonism… PDD or DLB?

A

DLB

39
Q

Presents in px with long -standing PD , who manifest dementia often with visual hallucinations, fluctuating attention or alertness, and RBD…… PDD or DLB?

A

PDD

40
Q

More frequently has AD co-pathology ….. PDD or DLB?

A

DLB

41
Q

Episodic memory disturbance points to the diagnosis of comorbid AD …. True or false

A

True

42
Q

common DDX for DLB

A
43
Q

timing of occurence of autonomic disturbances in MSA… early or late?

A
44
Q

San mas severe ang autonomic disturbances…. DLB or MSA

A
45
Q

San mas common ang ANOSMIA… LBD or MSA

A
46
Q

difference between PD-MCI and MCI-DLB in terms of cognitive impairment

A

00000 Neurology (3 decks)

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