43. Antimalarial drugs

Question 1

Treatment for malaria is not initiated until __

Answer 1

diagnosis has been confirmed by lab tests

Question 2

Antimalarial drugs affect the parasite during its __ cycle

Answer 2

asexual cycle (which takes place in the human body)

Question 3

Antimalarial class that inhibits DNA and RNA polymerase; disrupting protein synthesis

Answer 3

4-aminoquinolines

Question 4

Antimalarial class that inhibits an enzyme needed to produce vital substances in malarial parasites

Answer 4

diaminopyrimidines

Question 5

Antimalarial class that binds to an alters parasitic DNA

Answer 5

8-aminoquinolines

Question 6

Antimalarial drug contraindications

Answer 6

Drug allergy, tinnitus, pregnancy (quinine), severe renal, hepatic, or hematologic dysfunction

Question 7

Associated with serious neurologic and psychiatric side effects.

Answer 7

mefloquine

Question 8

Indicated for treatment of malaria, amebiasis; Anti-inflammatory actions; Contraindications in visual field changes, optic neuritis, and psoriasis; 4-aminoquinolines

Answer 8

chloroquine and hydroxychloroquine

Question 9

Prevention and treatment of malaria and multidrug-resistant P.falciparum; Black box warning for neuropsychiatric AEs, should not be used in pts w major psychiatric disorders; Analogue of quinine

Answer 9

mefloquine

Question 10

Can destroy parasites in exoerythrocytic phase; Contraindicated in blood disorders and G6PD deficiency; Similar to 4-aminoquinolones but classified as an 8-aminoquinoline

Answer 10

primaquine

Question 11

Contraindicated in pts with megaloblastic anemia caused by folate deficiency; diaminopyrimidine

Answer 11

pyrimethamine