42: CNS Stimulants and ADHD Flashcards
psychoactive drugs that stimulate the activity of CNS and PNS and temporarily enhance mental or physical functions
psychostimulants “uppers”
majority of CNS stimulants are chemically similar to…
NE
stimulate the flight or fight system
“sympathomimetics”
what do CNS stimulants increase?
alertness and awakeness productivity and motivation arousal, locomotion, HR, BP euphoria nervousness and anxiety
what do CNS stimulants decrease?
requirements for sleep and food intake
respiratory stimulant used to counteract postanesthetic respiratory depression
doxapram
binds to carotid a. chemoreceptors and medullary respiratory centers to increase tidal volume and respiratory rate
clinical use for caffeine
primary treatment for apnea of prematurity (breathing cessation in premature infants)
clinical use for theophylline
relaxes bronchial smooth muscle –> tx for COPD and asthma
MOA atomoxetine
NE reuptake inhibitor
what is the metabolism of CNS stimulants? why is that clinically important?
-peripheral degradation by MAOa/b and liver degradation via p450s
** avoid MAOi and SSRI agents (increase levels of drugs)
MOA analeptic stimulants
depression of inhibitory neurotransmission
GABAa and glycine antagonist –> decreased chloride influx and hyperpolarization
MOA methylxanthines
inhibition of CNS suppressant
reduce adenosine activity by A1 receptor antagonism
MOA amphetamines
enhancement of excitatory transmission
increase pre-synaptic release of catecholamines from vesicles/ decreases reuptake
MOA cocaine
enhancement of excitatory transmission
- inhibition of monoamine uptake via blockade of DA and NE and 5HT transporters
clinical use methylphenidate
ADHD
narcolepsy treatment
modafinil