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Pharmacodynamics > 4. Therapeutic Index > Flashcards

4. Therapeutic Index Flashcards

1
Q

what is TD50

A

the quantity / DOSE of a drug that causes TOXIC EFFECT in 50% of the POPULATION

TD = TOXIC DOSE

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2
Q

what is ED50

A

the DOSE of a drug that produces the DESIRED THERAPEUTIC EFFECTS in 50% of the POPULATION

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3
Q

what is LD50

A

the DOSE of a drug tat KILLS 50% of the POPULATION

LETHAL DOSE - in animal studies

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4
Q

what is meant by THERAPEUTIC INDEX (TI)

A

a statement of relative SAFETY of a DRUG

  • the BIGGER the TI, the SAFER the drug
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5
Q

what does THERAPEUTIC IDEX (TI) COMPARE

A

COMPARES the THERAPEUTICALLY EFFECTIVE DOSE to the TOXIC DOSE

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6
Q

what is THERAPEUTIC INDEX (TI) the RATIO of and how is it calculated

A

Ratio of the DOSE that PRODUCES TOXICITY to the DOSE that is NEEDED TO PRODUCE the DESIRED THERAPEUTIC RESPONSE

TI = TOXIC DOSE / DOSE FOR THERAPEUTIC RESPONSE

= TD50 / ED50

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7
Q

are the SLOPES for ED50 and TD50 always the same

A

NO, can be different

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Pharmacodynamics (3 decks)

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