(4) Pharmacodynamics

Question 1

Affinity

Answer 1

Tendenc of a drug to bind receptor

Question 2

Efficacy

Answer 2

Ability of a drug to initiate cellular effect

Question 3

Agonist

Answer 3

Drug with both receptor affinity and efficacy

Question 4

Partial Agonist

Answer 4

Drug with submaximal response that can act as an antagonist

Question 5

Antagonist

Answer 5

Drug w/ receptor affinity but no efficacy

Question 6

Potency

Answer 6

concentration of a drug required for a particular effect

Question 7

Median effective dose (ED50)

Answer 7

Dose producing 50% maximal response

Question 8

Median Lethal Dose (LD50)

Answer 8

Dose causing death in 50% subjects

Question 9

Therapeutic index (TI)

Answer 9

LD50/ED50

Higher TI= safer drug

Question 10

Graded dose-response curve

Answer 10

percent of maximum response vs. dose

Question 11

Quantal dose-response curve

Answer 11

Percent of subjects with response vs. dose (All or none)

Question 12

Tachyphylaxis

Answer 12

Acute tolerance

Question 13

Pharmacodynamic tolerance

Answer 13

Down regulation of receptors

Question 14

Pharmacokinetic tolerance

Answer 14

Upregulation of metabolic enzymes

Question 15

Pharmacogenetics

Answer 15

Study of genetic basis for variation in drug response

Question 16

Pharmacogenomic

Answer 16

Tools to assess multigenetic determinants of drug response

Question 17

Ideosyncratic drug reaction

Answer 17

unable to predict & usually genetically based

Question 18

Extensive metabolizer

Answer 18

Homozygous for WT CYP450

Question 19

Intermediate metabolizer

Answer 19

Heterozygous for WT and variant CYP450

Question 20

Poor metabolizer

Answer 20

Homozygous for variant

Question 21

Ultrarapid metabolizer

Answer 21

multiple copies of WT