[4] occupational risks (bloodborne pathogens) Flashcards
what are bloodborne pathogens ?
Examples of primary concern bloodborne pathogens? (3)
Pathogenic microorganisms, such as viruses, bacteria, or parasites, that are carried in the blood and can cause disease in people
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Human Immunodeficiency Virus (HIV)
what injuries may expose workers to bloodborne pathogens?
what occupations?
Needlesticks and sharp-related injuries
Workers in many occupations, including first responders, housekeeping personnel in some industries, nurses, and other healthcare personnel, may be at risk for exposure to bloodborne pathogens.
Hepatitis B (HBV)
Modes of transmission? (3)
A DNA virus that belongs in the Hepadnaviridae family
- Incubation period: 45-90 days
– Virus is given time to multiply inside our body before signs and symptoms of disease/ illness are manifested - High chances of progression to a chronic state
- Complications: 10-90% of cases may develop chronic hepatitis with increased risk for liver cirrhosis and hepatocellular carcinoma
– Chronic State: There is development to chronic hepatitis
– Hepatocellular carcinoma: Cancer of the liver
- Parenteral
- Sexual
- Perinatal
signs and symptoms of HBV?
how lang can HBV survive in dried blood?
Signs and Symptoms:
* Fever
*Fatigue
* Loss of appetite
* Nausea
* Vomiting
* Abdominal pain
* Voiding of dark urine
* Joint pain
* Jaundice
HBV can survive for at least one week in dried blood on environmental or contaminated needles and instruments
- Very low exposure to healthcare workers on the job especially if they follow strict safe practices and use of PPE to prevent transmission
- For healthcare workers on the job, the main risk is from being struck with HBV-contaminated needle or other sharp objects
Measures to prevent HBV infection (4)
1. Screening of blood donors
* Before bleeding to protect the recipient
2. Treating plasma-deprived products to inactivate HBV
* Treating blood component
3. Implementing infection-control measures
a. No recapping of the needle
b. Wearing of PPEs
c. Making sure that when performing blood collection procedures, you are thinking of your welfare
** 4. Immunization with Hepatitis B vaccine**
* Usually happens if you a healthcare worker inside the hospital and your job involves collecting specimens/ blood samples from your patient
* If your job involves processing of blood products (e.g. MedTechs in Blood Banking section)
* Immunization: Good step to prevent HBV infection
- Collecting specimens from patients
- Processing of blood products (blood banking section)
Hepatitis C (HCV)
Symptoms ? (7)
An enveloped, single-stranded RNA virus belonging to the Flaviviridae family
Modes of Transmission:
* Parenteral
* Sexual
*Perinatal
- High chances of progression to chronic state
Symptoms include:
* Jaundice
* Fatigue
* Abdominal pain
* Loss of appetite
* Intermittent nausea
* Dark urine
* Joint pains
Human Immunodeficiency Virus (HIV)
Former names? (4)
The etiologic agent of the acquired immunodeficiency syndrome (AIDS)
Former names:
* HIV-1 (discovered in 1983-1984)
* Human T-Cell Lymphotropic Virus - Type III (HTLV-III)
* Lymphadenopathy-Associated Virus (LAV)
* AIDS-Associated Retrovirus (ARV)
HIV-2
Modes of Transmission? (3)
- A related but genetically distinct virus from HIV-1 which was discovered in 1986
- Majority of infections occurred in West Africa
- Transmitted in the same manner as HIV-1 and may also cause AIDS
- Less pathogenic and has a lower rate of transmission
HIV TRANSMISSION
3 major routes:
* Intimate sexual contact
* Contact with blood or other body fluids
* Perinatal (from infected mother to infant)
Bloodborne Pathogens
Diseases caused by bloodborne pathogens: (8)
Diseases caused by bloodborne pathogens:
* Syphilis
* Malaria
* Zika
* Babesiosis
* Brucellosis
* Creutzfeldt-Jakob Disease
* Human T-Lymphotropic Virus Type I
* Ebola Virus Diseases
Syphilis
How many stages and what are their names?
- An infection caused by a spirochete, Treponema pallidum
- Mode of transmission:
– sexual contact (primary mode of dissemination)
vaginal, anal or oral sex, especially direct contact with syphilis source, which is usually in the genital area
– perinatal route
pregnant women with syphilis infection to their unborn child - Coils and Periplasmic flagella
– characteristics structures of Treponema pallidum
Has 4 stages:
* Primary Stage
* Secondary Stage
* Latent Stage
* Tertiary Stage
(1) Contact with a susceptible skin site = thickening of endothelial cells that usually occurs with the aggregation of lymphocytes, plasma cells and macrophages
Primary Stage of Syphilis (6)
- characterized by the appearance of sore/initial lesion/chancre
- Sore appears at the spot where the bacteria entered the body
- Chancre usually develops between 10 to 90 days after infection, with about 21 days being the average
- Usually painless, solitary lesion characterized by well-defined borders
- In men, usually occurs outside the penis, but in women may appear in the vagina or on the cervix and may go undetected
- usually lasts from 1 to 6 weeks, during which the lesion may heal spontaneously
Secondary Stage of Syphilis (4)
Symptoms? (5)
- progression from the inability of treatment to the initial chancre where systematic dissemination of the organism usually happens
- Patients may exhibit neurological signs such as visual disturbances, hearing loss, tinnitus, and facial weakness
- Lesions persist from a few days up to 8 weeks
- Spontaneous healing occurs, as in the primary stage
Symptoms:
* generalized lymphadenopathy
* malaise
* fever
* pharyngitis
* rash on the skin and mucous membranes (rash in palms and soles of the feet)
– may not be itchy and can be accompanied by wart-like sores in the mouth and genital area
Latent Stage of Syphilis (3)
2 types?
- Follows the disappearance of the secondary syphilis
- Characterized by a lack of clinical symptoms
– but the causative agent of the infection is still present inside the body -
Patients are noninfectious at this time, except for pregnant women
transfer from mother to fetus
2 types:
* Early latent syphilis
– less than 1 year’s duration
* Late latent syphilis
– primary infection has occurred more than 1 year previously
Tertiary Stage of Syphilis (2)
3 major manifestations? + explanation(?)
- Appears anywhere from months to years after secondary infection if patient remains untreated
- Occurs most often between 10 and 30 years following secondary stage
Three major manifestations:
Gummas/Gummatous lesions
* localized areas of granulomatous inflammation that are most often found in bones, skin or subcutaneous tissue
* lesions contain lymphocytes, epithelial cells, and fibroblastic cells that may heal spontaneously with scarring or they may remain destructive areas of chronic inflammation
Cardiovascular disease
* Complications involve the ascending aorta, and symptoms are due to destruction of elastic tissue
* May result to aortic aneurysm, thickening of the valve, aortic regurgitation, and angina pectoris which may be fatal to the patient
Neurosyphilis
* The complication most often associated with the tertiary stage
* Can actually occur anytime after the primary stage and can span all stages of the disease
Malaria (2)
First symptoms?(3) + when do they appear.
- A life-threatening parasitic disease caused by infection with Plasmodium protozoa transmitted by an infective female Anopheles mosquito (vector of transmission)
- Plasmodium falciparum and Plasmodium vivax pose the greatest threat
First symptoms include
* fever
* headaches
* chills
(appear 10-15 days after the infective mosquito bite)
Zika (2)
- what are the symptoms and how long do they last?
- what is the common symptom(?) of zika?
- Caused by a virus transmitted primarily by the bite of an infected Aedes species mosquito (A. aegypti or A. albopictus) which feeds during the day.
- Zika virus can also be transmitted from mother to fetus during:
pregnancy, sexual contact, transfusion of blood and blood products, and possibly through organ transplantation.
- Symptoms of infection include:
rash, fever, conjunctivitis, muscle and joint pain, malaise and headache, usually lasting for 2-7 days.
Microcephaly
* a condition characterized by an abnormally small head circumference
* can be caused by a variety of factors, including genetic abnormalities and infections during pregnancy (like Zika virus)
Babesiosis (2)
- Caused by Babesia microti is transmitted by the bite of infected Ixodes scapularis ticks
– typically, by the nymph stage of the tick, which is about the size of a poppy seed - Babesia parasites infect and destroy red blood cells which results to hemolytic anemia (leading to jaundice and dark urine
Brucellosis
other names? (4) + in animals?
- Zoonotic infection caused by the bacterial genus Brucella
- Transmitted from animals to humans by ingestion through infected food products, direct contact with an infected animal, or inhalation of aerosols.
Other names:
* Mediterranean fever
* Malta fever
* gastric remittent fever
* undulant fever
- In animals, Brucella infection often causes spontaneous abortion. In humans, it leads to Brucellosis, which typically presents as fever (e.g. undulant fever or Malta fever)
BRUCELLOSIS
B. abortus - give the host/s (4-7) and corresponding diseases (4)
geographical distribution? (4)
- cattle - abortion and orchitis
- sheep, goats, camels, pigs - sporadic abortion
- horses - associated with bursitis (poll evil and fistulous withers)
- humans - undulant fever
Foci of infection can persist in wildlife such as bison and elk in the USA Biovars:
1. Worldwide (common)
2. Worldwide (not common)
3. India, Egypt, East Africa
4. Britain and Germany
Other biotypes are infrequently isolated
BRUCELLOSIS
B. melitensis - give the host/s (4-5) and corresponding diseases (3)
geographical distribution?
- goats - abortion
- sheep -
- cattle, camels - occasional abortion and excretion of milk
- humans - malta fever
Many sheep- and goat-raising regions, except New Zealand, Australia and North America
BRUCELLOSIS
B. suis - give the host/s (3) and corresponding diseases (3)
geographical distribution? (5)
- pigs (including wild boar) - abortion, orchitis, arthristis, spondylitis, and herd infertility
- cattle (biovar 1) - excretion in milk
- humans - undulant fever (not biovar 2)
Some biovars may persist in wildlife.
Biovars:
1. Worldwide
2. Western and Central Europe, also infects hares
3. USA, Argentina, and Singapore
4.The Arctic Circle (Canada, Alaska, and Siberia) also infects reindeer and caribou
5. Isolated from rodents in the Yormer USSR
Brucella infection causes what in animals and humans?
In animals, Brucella infection often causes spontaneous abortion. In humans, it leads to Brucellosis, which typically presents as fever (e.g. undulant fever or Malta fever)
Creutzfeldt-Jakob Disease (CJD) (4)
signs and symptoms? (8)
- A rare brain disorder that leads to dementia is believed to be caused by a protein known as prions.
- It belongs to a group of human and animal diseases known as prion disorders.
- Prions are abnormal pathogenic agents that can be transmissible and induce abnormal folding of normal cellular proteins, known as prion proteins, which are mostly abundant in the brain.
- A person develops this disease due to prion transmission during medical interventions, such as exposure to infected human cadaveric-derived pituitary hormones, dural and corneal grafts, or contaminated neurosurgical instruments.
CJD is marked by changes in mental abilities, including
* personality changes
* memory loss
* impaired thinking
* blurry vision or blindness
* insomnia
* problems with coordination
* trouble speaking or swallowing
* sudden jerky movements.
○ All these signs and symptoms are manifestations of CJD because prions affect the brain, which controls most of the body’s movements.
Types of CJD (3)
ennumerate
- Sporadic CJD
- Hereditary CJD
- Acquired CJD