4. Musculoskeletal System Flashcards
What 4 main cells play a role in bone remodelling?
- Osteoprogenitor cell - stem cell
- Osteoblast - matrix-synthesising cell responsible for bone growth
- Osteocyte - mature bone cell which monitors and maintains the mature bone matrix
- Osteoclast - bone-resorbing cell
What are the 5 main roles of bones in vertebrates?
- Act as primary load-bearing organ (mechanical support)
- Works to protect underlying organs
- Provides a rigid support structure for musculature
- Contributes to calcium and phosphorus homestasis
- Active participant in many endocrine processes
What factors determine the ability of bone to resist damage, and subsequent fracture?
- Direction of load applied
- Magnitude of load applied
- Rate at which the load is applied
- Species of animal
- Age of animal
- Overall and individual bone health
What are the regions of a long bone from proximal to distal?
- Proximal epiphyseal bone
- Proximal epiphyseal line (physeal line in immature animals)
- Proximal metaphyseal bone
- Diaphyseal bone
- Distal Metaphyseal bone
- Distal epiphyseal line
- Distal epiphyseal bone
What 3 systems deliver blood to a long bone?
A. Nutrient artery system - enters the cortex through a nutrient foramen and into the medulla
B. Metaphyseal-epiphyseal system - periarticular vascular plexus arising
C. Periosteal system - supplies outer 1/3rd of bone
What are the 5 forces a bone is subject to?
- Compression
- Tension
- Shear
- Torsion
- Bending
What methods may bone heal via?
- Primary or direct bone healing - (1a. contact healing or 1b. gap healing)
- Secondary or indirect bone healing
When does primary bone healing occur?
Where absolute stability of the fracture occurs, i.e. with anatomic reconstruction, compression of bone fragments and rigid fixation of the bone column
What is primary bone healing?
Mechanism of healing in which cortical bone attempts to directly re-establish continuity without the formation of a callous
What are the two types of primary bone healing?
- Contact healing - fracture gap of < 0.01 mm or 10 um, and interfragmentary strain is functionally eliminated at < 2%
- Gap healing - gap must not be > 1 mm
Describe the process of primary bone contact healing
- direct appostion of fracture ends
- direct remodelling
- cutting cone initiated in fracture region
- reduced radiographic density at bone ends adjacent to the fracture site
Describe the process of primary bone gap healing?
- small gaps < 1 mm between fracture ends
- minimal movement of fracture site
- lamellar bone forms directly in the fracture gap
- intracortical remodelling through fracture gap and bone restoration occurs
What are the stages of secondary bone healing?
- Inflammation
- Intramembranous ossification
- Soft callous formation (chondrogenesis)
- Hard callous formation (endochondral ossification)
- Bone remodelling
Describe the time periods of secondary bone healing?
Describe the Salter-Harris fracture system?
Describe delayed unions, non-unions and malunions?
What are the 5 key points of fracture description?
What are the 3 categories of fracture assessment?
What fixation methods exist for reconstructible (primary bone healing) vs non-reconstructible (secondary bone healing) fractures?
What are the 4 A’s of fracture assessment?
Define the terms stress and strain?
Stress = the internal force that resists the applied force is called stress
Strain = The deformation of the material caused by the external forces is called strain
Is bone stronger in tension or compression?
Compression