4 - Autoimmunity Mechanisms Flashcards
What is the definition of autoimmunity and an autoimmune disease?
What are the two patterns of autoimmune disease?
- Organ specific
- Non-Organ specific
What are the self antigens in the following conditions/?
Which systems in the body do auto-immune diseases commonly affect?
- Nervous disease
- Respiratory disease
- Endocrine disease
- Joint diseases
- Haematological disease
What type of hypersensitivity reactions are the following autoimmune diseases?
What are the two mechanisms of tissue damage in autoimmune conditions?
- Autoantibodies
- Autoreactive T Cells
What are the five criteria for diagnosing an autoimmune condition?
Immunomodulatory therapy is monoclonal antibodies
What are some autoimmune conditions that have primary autoantibodies?
What are some autoimmune antibodies that have secondary autoantibodies?
How can we detect autoantibodies/autoreactive T cells?
- Biopsy tissue to see lymphocytes
- Immunofluroescene of serum on healthy tissue
- Serum levels of autoantibodies
What are some autoimmune conditions that a mother may have that can be passed onto the baby?
IgG crosses over placenta so baby will experience symptoms for first 6 months of life
What causes induction of autoimmunity?
Loss of tolerance
What are some triggers of autoimmunity?
- Genetic Factors
- Environmental Factors
What are some infections that can lead to autoimmune conditions?
Mimicry - infection has antigen similar to a self antigen!!
What are some drugs that can lead to autoimmune syndromes?
What are some of the autoantibodies for SLE?
- ANA
- Anti-dsDNA
What therapeutic strategies can be used for treated autoimmune conditions?
- Autoantibodies: plasmapheresis and monoclonal antibodies
- Autoreactive T Cells: immunosupressive drugs and monoclonal antibodies
- Tissue damage: antiinflammatory drugs e.g steroids
- Organ dysfunction: replacement therapy or surgery
What do all monoclonal antibody drugs end in?
- MAB
Very few side effects as targeted to specific protein
What therapeutic strategies are used for the following autoimmune diseases?
Think about disease process to think about therapy
