3MB Drugs

Question 1

SSRI mechanism

Answer 1

Selective Serotonin Reuptake Inhibitor

Selectively inhibit reuptake of serotonin (5HT) from the synaptic cleft

Question 2

MAOI mechanism

Answer 2

Monoamine oxidase inhibitors.

Irreversible or reversible inhibitors of MAO-A and MAO-B

Question 3

Tricyclic Antidepressants (TCAs) mechanism of action

Answer 3

Block reuptake of monoamines into presynaptic terminals

mainly noradrenaline and 5HT.

Question 4

SNRIs mechanism

Answer 4

Serotonin & Norepinephrine Reuptake Inhibitors

Block the reuptake of monoamines (noradrenaline and serotonin, or 5HT) into presynaptic terminals

Fewer side effects than tricyclics.

Question 5

Lithium mechanism

Used in

Answer 5

Inhibit glycogen synthase kinase 3beta

block phosphatidylinositol pathway

Used in bipolar affective disorder (reduce mood in episodes of mania, raises mood in depression)

Question 6

Drug classes used for anxiety

Answer 6

Benzodiazepines
SSRIs
Tricyclics
Pregabalin

Question 7

What are the two classes of antipsychotics?

Answer 7

Typical (1st generation)

Atypical (2nd generation)

Question 8

Which class of antipsychotics are more likely to induce extra pyramidal side effects?

Answer 8

Typical (1st gen)

Question 9

List some extra pyramidal side effects (EPSE)

Answer 9

Acute dystonic redaction

Parkinsonism

Akathisia

Tardive dyskinesia

Question 10

What is acute dystonic reaction

What can it be treated with?

Answer 10

Painful, non voluntary muscle spasms

Occurs early on in antipsychotic treatment.

Acetylcholine antagonists

Question 11

Parkinsonism

Answer 11

Tremor, rigidity, slowness of gait

Takes days-months to develop

anticholinergics help

Question 12

Akithisia

Answer 12

Internal restlessness. Fidgeting, wriggling, pacing, walking on the spot.

Constantly feel the need to move.

Question 13

Tardive dyskinesia

Answer 13

Repetitive involuntary purposeless movements

grimacing, sticking tongue out, lip smacking, blinking

Takes years to develop.

Question 14

Prochlorperazine, Procyclidine and Orphenadrine are examples of what?

Answer 14

Acetylcholine antagonists.

Question 15

Which receptor do typical (1st gen) antipsychotics target?

Answer 15

D2 inhibition

dopamine

Question 16

Chlorpromazine, Thioridazine, Fluphenazine are examples of which class of antipsychotic?

Answer 16

Typicals

Question 17

Haloperidol

Answer 17

Typical antipsychotic

Question 18

Hyperprolactinaemia is more common in which type of antipsychotics?

Answer 18

Typical antipsychotics.

Prolactin secretion under inhibitory control of dopamine. Typicals inhibit dopamine receptors leading to disinhibition and increase of prolactin.

Question 19

Clozapine (atypical) has which dangerous side effect

Answer 19

Agranulocytosis

Question 20

Is metabolic syndrome a more common side effect of typical or atypical antipsychotics?

Answer 20

Atypicals

Question 21

Metabolic syndrome

Answer 21

Side effect of atypical antipsychotics

Weight gain
Increased abdominal girth
T2DM
High blood pressure
abnormal cholesterol

Question 22

Olanzapine, Risperidone, Quetiapine, aripiprazole and amisulpride are types of?

Answer 22

Atypical antipsychotics

Question 23

Chlorpromazine, Thioridazine, Fluphenazine, Haloperidol and Zuclopentixol are types of?

Answer 23

Typical antipsychotics

Question 24

Midazolam, Loprazolam, Temazopam are types of?

Answer 24

Benzodiazepines

Question 25

Drug classes used for depression

Answer 25

SSRIs, MAOIs, Tricyclic Antidepressants , SNRIs

Question 26

Venlafaxine and duloxetine are examples of which type of drug?

Answer 26

SNRIs