38 Behcet Disease Flashcards

1
Q

Criteria for pediatric BD

A

3/6
Recurrent oral aphthosis (3/year)
Genital ulceration typically with a scar
Skin features: Acneiform lesions, necrotic folliculitis, erythema nodosum
Ocular: Anterior/post uveitis, retinal vascultiits
Neuro signs, EXCEPT headache
Vascular: Venous/arterial thrombosis, arterial aneurysm

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2
Q

Equal M:F, adult vs child

A

Child, adult men 2x as women

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3
Q

Strongest genetic assoc with BD

A

HLA B*5101

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4
Q

T/F 1 of the most characteristic features of BD is the heterogeneity of clinical presentation

A

T

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5
Q

Involvement of this organ system is increased in the clinical presentation of BD among ASIANS

A

GI

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6
Q

T/F Oral ulcerations in BD are usually painless

A

F, extremely painful

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7
Q

Oral ulcers of BD generally last for how long

A

3-10days

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8
Q

BD: HEal with scarring, oral vs genital ulcers

A

Genital ulcers

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9
Q

Unusual cutaneous pustular reaction occurring 24-48h after needle puncture of the dermis

A

Pathergy test

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10
Q

T/G Pathergy test is pathognomonic of BD

A

F, highly characteristic but NOT pathognomonic

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11
Q

Typical eye involvement of BD

A

Chronic relapsing bilateral anterior and posterior uveitis

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12
Q

MC CNS manif of BD in children

A

Increased ICP from cerebral venous sinus thrombosis

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13
Q

T/F Joint disease in BD does NOT usually result in erosions or joint deformities

A

T

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14
Q

The only vasculitis that involves both arterial and venous systems and can affect a vessel of any size

A

BD

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15
Q

Adult vs child BD: Superficial/deep venous thromboses

A

Adult

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16
Q

T/F GI lesiosn of BD are histologically indistinguishable from UC and Crohn’s

17
Q

MC renal manif of BD

A

AMyloidosis and GN

18
Q

T/F Cardiac manif are rare in BD

19
Q

Prominent infiltrating cells in the synovium, skin, and eye lesions of BD

A

Neutrophils

20
Q

Cytokine with a clear role in the pathogenesis of BD

A

IL-17, Highlights importance of IL-23/IL-17 pathway

21
Q

Most important imaging studies in BD to delineate extent and character of vascular lesions

22
Q

Most important imaging studies in BD to evaluate CNS effects of the diease

23
Q

GI lesions of BD are most frequently where

24
Q

1st line treatment for oral and genital ulcers of BD

A

Topical sucralfate suspension or topical CS

25
Role of oral CS in BD
Fast relief during acute stage of ulceration
26
Option for severe BD ulceration
Thalidomide
27
Issues with thalidomide
High risk of peripheral neuropathy Contraindicated in pregnancy
28
Other options for tx of ulcers in BD
Colchicine, anti-TNF esp Inflix
29
Treatment of ocular BD
AZA, systemic CS REsistant: Add Cyclosporine or inflix, adalimumab
30
First-line for manif of BD other than ocular and ulcers
Prednisone
31
Steroid-sparing agent for GI BD
Sulfasalazine
32
Steroid-sparing agent for CNS BD
Aza, anti-tnf, CYC
33
T/F BD is usually monophasic
F, long relapsing course
34
Indicators of prolonged BD
Young age Male
35
Organ system involvement in BD that can be severely incapacitating
Ocular and CNS