3.6/3.7 Proteins Flashcards

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1
Q

What is the protein structure consisted of?

A

one or more polypeptide chains folded in a 3D shape

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2
Q

What is the primary structure of a protein?

A

Order of amino acids determined by genetic code

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3
Q

What is the secondary structure of proteins?

A

alpha helix coil or beta pleated sheet

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4
Q

What is the tertiary structure of proteins?

A

how a protein is further folded (globular shape - 3D)

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5
Q

What is the quaternary structure?

A

more than one polypeptide chain, held together by bonds

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6
Q

Where are hydrogen bonds formed?

A

they are formed between R groups, and are numerous and easily broken

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7
Q

Where are disulphide bonds together?

A

formed between sulphur containing amino acids - found in skin/hair

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8
Q

What are the properties of globular proteins?

A

Proteins rolled into a ball are globular, they are are soluble, used in metabolism and as enzymes.

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9
Q

What are the main components of an alpha helix?

A
  • Hydrogen bonds form between oxygen and hydrogen molecules brought into close proximity
  • Help to stabilise a structure
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10
Q

What are the main components of a beta pleated sheet?

A
  • folds back upon itself many times forming anti-parallel chains
  • forms hydrogen bonds
  • stability
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11
Q

What are hydrogen bonds?

A

Hydrogen and oxygen atoms from both the main chain and the R group may form hydrogen bonds

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12
Q

What are Disulphide Bridges?

A

The R groups of two amino acids contain sulphur atoms, when in close proximity, form disulphide bridges

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13
Q

What are Ionic bonds?

A

Many of the carboxylic acid and amino groups form charged groups in solution, oppositely charged groups form ionic bonds

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14
Q

What are Hydrophobic interactions AKA covalent bonds?

A

many hydrophobic R groups tend to cluster towards the interior of the protein molecule forming hydrophobic interactions

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15
Q

What are proteins?

A
  • proteins can be enzymes, hormones and oxygen transporters (i.e. haemoglobin),
  • 3D complex microscopic molecules,
  • polymers called polypeptides
  • made up of amino acid units
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16
Q

Where can proteins be found in people?

A

bulk of skin, hair, nails/feathers (keratin), and cartilage (smoothness in joints)

17
Q

Where can amino acids be found?

A

seeds, nuts, pulses, beans, meat

18
Q

What is the structure for a protein?

A

. R
|
H2N——–C——–COOH
|
H

19
Q

What is the structure for a protein undergoing condensation?

A

. H R1 O H R2 O
| | || | | ||
N—-C- –C–condensation– N–C–C
| | | |
H H H OH

20
Q

What is the bond formed during a condensation reaction?

A

A Peptide bond

21
Q

What are two amino acids joined together called?

A

Dipeptide

22
Q

What are many amino acids joined together called?

A

Polypeptide

23
Q

What is the R group?

A

A variable unit, eg. hydrogen

24
Q

What is the amino acid group?

A

H2N (left)
- AKA Basic Group (neutralises acidic group)

25
Q

What is the carboxylic group?

A

COOH (right)
- AKA Acidic group (neutralises basic group)

26
Q

Where do excess amino acids go?

A

stored as NH2 (ammonium), released into urea

27
Q

What is the simplest amino acid that possesses hydrogen as its R group called?

A

Glycine - every third amino acid in a polypeptide chain

28
Q

What is the shape of an amino acid?

A

Tetrahedral shape, over 90 degree angles of the bonds between the atoms

29
Q

how many different naturally occuring amino acids are there?

A

20, that differ by virtue of the R group

30
Q

What R group does Alanine have?

A

CH3, one basic, one acidic group

31
Q

What amino acid has sulphur in its R group?

A

Cysteine/ Methionine

32
Q

What are the main components of collagen?

A
  • Fibrous protein
  • connective tissue
  • triple helix
  • flexibility
  • Tropocollagen is formed when quaternary proteins have staggered ends which join together (strong polypeptide)
33
Q

What are the main components of elastin?

A
  • Fibrous protein
  • can expand/shrink when needed due to having elastic fibres which allow flexibility
  • quaternary protein made from tropoelastin
  • insoluble
  • confers strength and elasticity to the skin, organs and tissues
  • found in alveoli and walls of blood vessels
  • strengthened by cross-linking covalent bonds
34
Q

What are the main components of Keratin?

A
  • Fibrous protein
  • has a lot of the sulphur containing amino acid, Cysteine
  • many strong disulphide bonds
  • strong, inflexible and insoluble
  • degree of disulphide bonds determines flexibility
  • quaternary structure
35
Q

What are the main components of Catalase?

A
  • Conjugated protein
  • enzyme (Active site)
  • quaternary protein that catalyses reactions
  • contains four haem prosthetic groups with iron 2 ions, allowing interaction with hydrogen peroxide (substrate) (toxic by-product of metabolism) and speeds up its breakdown
  • antioxidant, present in all aerobic organisms
  • 2H2O2 –> 2H2O + O2
36
Q

What are the main components of Haemoglobin?

A
  • red, oxygen carrying pigment found in red blood cells (carries oxygen form lungs to all cells where it is released)
  • quaternary protein made from four polypeptides
    (2 alpha, 2 beta subunits - each contains a prosthetic haem group which has iron 2 ions present and are able to combine reversibly with an oxygen molecule)
  • found in muscle cells as myoglobin
  • some amount of carbon dioxide is transported back via haemoglobin as carbaminohaemoglobin