358 Inflammatory Myopathies Flashcards

1
Q

represent the largest group of acquired and potentially treatable causes of skeletal muscle weakness

A

inflammatory myopathies

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2
Q

Three major groups of inflammatory myopathies

A

polymyositis, dermatomyositis and inclusion body myositis

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3
Q

True or false. These disorders present as a progressive and symmetric muscle weakness except to IBM which can have an asymmetric pattern

A

True

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4
Q

True or false. Falling is common in IBM as the quadriceps are affected early leading to buckling of the knees.

A

True

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5
Q

Muscles spared in inflammatory myopathies even in advance cases

A

ocular muscles

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6
Q

True or False. Ocular and facial muscles are spared in inflammatory myopathies.

A

False. It is only spared in PM and DM; in IBM it is commonly affected

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7
Q

True or false. All types of inflammatory myopathies involve the pharyngeal and neck flexor muscles causing dyspahge and head drop

A

True

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8
Q

Inflammatory myopathis frequently associaed with SLE

A

Polymyositis

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9
Q

Which inflammatory myopathy affects both children and adults

A

dermatomyositis

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10
Q

Which inflammatory myopathy affect older population, those aging more than 50 years old

A

inclusion body myopathy

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11
Q

Connective tissue disorder associated with dermatomyositis

A

scleroderma and mixed connective tissue disorder (overlap syndrome)

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12
Q

Inflammatory myopathy associated with all drugs, virus, parasides and bacteria

A

polymyositis

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13
Q

Inflammatory myopathy associated with malignancy

A

dermatomyositis

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14
Q

inflammatory myopathy associated with virus infection and which one is not

A

Polymyositis and IBM can be associated with virus while it is not proven in DM

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15
Q

distinctive inflammatory myopathy characterized by an accompanying rash which more often precede the muscle weakness

A

dermatomyositis

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16
Q

rash that consists of blue purple discoloration on the upper eyelids of edema; and which inflammatory myopathy is it associated

A

heliotrope rash of dermatomyositis

17
Q

flat red rash on the face and upper trunk; erythema of the knuckles with raised violaceous scaly eruption

A

Gottron’s sign of dermatomyositis

18
Q

erythematous rash on the elbows, malleoli, neck and anterior chest

A

V sign of dermatomyositis

19
Q

erythemous rash in the back and shoulders

A

shawl sign of dermatomyositis

20
Q

cuticles may ne irregular, thickened, distorted and the lateral and palmar areas of the fingers may become rough and cracked with irregular “dirty” horizontal lines

A

mechanic’s hands of dermatomyositis

21
Q

fasciitis and thickening of skin associated with ingestion of contaminated L tryptophan

A

eosinophilia-myalgia syndrome

22
Q

most common of the inflammatory myopathies in patients more than 50 years of age

A

inclusion body myopathy (IBM)

23
Q

True or false. weakness and atrophy of the distal muscles esp foot extensors and deep finger flexors occurs in almost all cases IBM

24
Q

True or false. Dyphagia is common in IBM occuring at 60%

25
Inflammatory myopathy associated with joint contractures
dermatomyositis
26
dyphagia and GI symptoms are associated with which inflammatory myopathies
dermatomyositis and IBM
27
True or false. signs of RA, SLE or Sjogrens syndrome are very rare in patients with DM
True
28
critical early event that triggers release of proinflammatory sytokines and chemokines in dermatomyositis
activation of complement C5b-9
29
immunopathologic characteristic of PM and IBM; its presence can aid in confirming the histologic diagnosis of PM
CD8/MCH-1 complex
30
Viruses associated with myositis
coxsackievirus, influenza, paramyxoviruses, mumps, CMV and EBV
31
Best evidence of viral connection in PM and IBM
retroviruses
32
antiretroviral drug which may present with fatigue, myalgia, mild muscle weakness and mild elevation of creatine kinase
zidovudine (AZT)
33
How does AZT lead to myopathy
inhibits DNA polymerase found i in mitochodrial matrix; seen in long term therapy
34
How is AZT induced myopathy managed
improves when drug is discontinued
35
in Asia, malignancy associated with dermatomyositis
nasopharyngeal malignancy