3.4 Mass Transport Flashcards
How many polypeptide chains are in the quaternary structure of haemoglobin?
4
Each polypeptide chain in haemoglobin has a what group with what ion?
Haem group and an iron ion
What makes haemoglobin red?
The iron ion
How many molecules of oxygen can bind to a haemoglobin molecule?
4
What is formed when oxygen binds to haemoglobin?
Oxyhaemoglobin
What is dissociation?
When oxygen is released from the oxyhaemoglobin
What is partial pressure of oxygen?
Concentration of oxygen
How does high partial pressure of oxygen affect haemoglobin’s affinity for oxygen?
High affinity
How does low partial pressure of oxygen affect haemoglobin’s affinity for oxygen?
Low affinity
What is the affinity for oxygen like for animals at a high altitude and why is it beneficial?
Haemoglobin has a high affinity for oxygen which is beneficial as air at high altitudes has a lower partial pressure of oxygen.
What is the affinity for oxygen like for animals with a high metabolic rate and how is it beneficial?
Low affinity for oxygen as oxygen is used quickly in respiration so needs to be supplied often
Explain how the binding of one molecule of oxygen to haemoglobin helps others to bind
When the first molecule of O2 binds to haemoglobin, the protein undergoes a conformational change.
The change in shape allows the other O2 molecules to bind to haemoglobin more easily.
The percentage saturation of haemoglobin increases quickly.
Explain why the percentage saturation of haemoglobin begins to plateau at the top of the dissociation curve
As more molecules of O2 bind to haemoglobin, it becomes more difficult for more O2 molecules to bind.
The percentage saturation of haemoglobin begins to plateau.
What shape is the oxyhaemoglobin dissociation curve?
S-shaped
How does a higher partial pressure of carbon dioxide affect haemoglobin’s affinity for oxygen and what is this effect called?
High partial pressures of carbon dioxide cause a low affinity for oxygen in haemoglobin. The dissociation curve moves to the right and oxygen can dissociate from haemoglobin at lower partial pressures of oxygen. This is the Bohr effect.