[34] Definitions, Mechanisms, and Diagnosis of Labour Flashcards
What is labour also known as?
Parturition
What is the definition of labour?
The process whereby the products of conception are expelled from the uterine cavity after the 24th week gestation
What is ‘term’ labour?
When labour occurs between 37-42 weeks
What percentage of mothers deliver at ‘term’?
93-94%
What is pre-term labour?
When labour occurs from 24-36+6 weeks
What percentage of mothers deliver pre-term?
7-8%
What is it called when the contents of the uterus are delivered before 24 weeks?
Miscarriage
Why is miscarriage different to labour?
The fetus is not viable (although som pre-term births may not survive either)
What is prolonged labour in primigravida?
> 24 hours
What is prolonged labour in multigravida?
> 16 hours
What is prolonged labour associated with?
Increased fetal and maternal morbidity and mortality
What happens before labour?
Pre-labour phase
How long can the pre-labour phase last?
Days - weeks
How is labour divided in clinical management?
Into 3 stages
What are the three stages of labour called?
- First stage
- Second stage
- Third stage
Imaginative isn’t it
What marks the start of the first stage of labour?
Onset of regular painful contractions and cervical changes
What marks the end of the first stage of labour?
When the cervix reaches full dilation and is no longer palpable
What can the first stage of labour be further divided into?
- Early latent phase
- Active phase
What happens in the early latent phase of the first stage of labour?
Cervix becomes effaced and shorter from 3cm in length and dilates up to 3 cm
What happens in the active phase of the first stage of labour?
Cervix dilates from 3cm to full dilation (or 10cm)
What marks the start of the second stage of labour?
Full cervical dilation
What marks the end of the second stage of labour?
Delivery of the fetus
What can the second stage of labour be divided into?
- Pelvic or passive phase
- Active phase
What happens in the pelvic/passive phase of labour?
The head descends from the pelvis
What happens in the active phase of labour?
The mother gets a stronger urge to push and the foetus is delivered by the force of the uterine contractions and maternal bearing down
What happens in the third stage of labour?
Delivery of the placenta and membranes
What hormonal changes take place to initiate the onset of labour?
- Progesterone withdrawal
- Increase in oestrogen
- Increase in prostaglandin action
What is likely to be involved in regulating the hormonal changes that naturally induce labour?
Corticotrophin-releasing hormone (CRH)
Where is CRH produced?
Placenta
Where in the placenta is CRH produced?
Syncitiotrophoblasts
What happens to the number of syncitiotrophoblast nuclei throughout gestation?
Increase
What is the effect of the number of syncitiotrophoblast nuclei increasing during gestation?
There is an exponential increase in the levels of maternal and fetal plasma CRH
What are the effects of CRH on the placenta?
- Increases production of oestrogen
- Decreases production of progesterone
What is the effect of CRH on the membranes?
Increased synthesis of prostaglandins
What molecule is increased by the changes in prostaglandin, progesterone and oestrogen levels throughout pregnancy?
Connexin 43
What does connexin 43 promote?
- Connectivity of the uterine myocytes
- Increases myocyte excitability
What is the result of connexin 43’s effects on the uterine myocytes?
Generalised uterine contractions
How do contractions of uterine myocytes differ to striated muscle contraction?
They shorten and remain so (striated muscle returns to normal length upon relaxation)
What other placental hormones can affect myometrial contraction?
- Relaxin
- hCG
- Activating A
Why is the integrity of the cervix essential throughout gestation?
To retain the products of conception
What cells are found in the structure of the cervix?
Myocytes and fibroblasts
How does the integrity of the cervix change towards term?
It becomes soft and stretchable
What causes the cervix to become soft and stretchable towards term?
Increase in leukocyte infiltration and a decrease in the amount of collagen due to increased proteolytic enzyme activity
What changes to the connective tissue of the cervix cause softening and stretching?
Increased hyaluronic acid to reduce affinity of fibronectin for collagen
What is the softening and stretching of the cervix called?
Ripening of the cervix
What changes to cervical and uterine physiology are required in labour?
- Reduced cervical resistance
- Increased frequency, duration and strength of uterine contractions
Are contractions present in pregnancy before labour?
Yes
Describe the pre-labour contractions experienced throughout pregnancy?
Painless and irregular
How do pre-labour contractions progress throughout pregnancy?
They are minimal at the start and become more frequent as pregnancy progress towards labour
What is uterine contractile activity regulated by?
The fetoplacental unit
What causes the increased contractile activity at the end of gestation?
Down-regulation of factors that keep the uterus and cervix inactive and upregulation of procontractile influences
What is the result of the changes in uterine contractile activity at the end of gestation?
Increased frequency, duration and strength of contractions
What is the effect of progressive uterine contractions on the cervix in labour?
Causes effacement and dilatation