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HEMA 2 LEC > 3.3-COAGULATION FACTORS > Flashcards

3.3-COAGULATION FACTORS Flashcards

1
Q

What are the three classifications of blood factors?

A

Substrate, Zymogen, Cofactor

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2
Q

What is a zymogen?

A

An enzyme precursor

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3
Q

What is a cofactor?

A

A component that aids in the activation of a zymogen to an active enzyme

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4
Q

Which ion is necessary for coagulation?

A

Calcium

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5
Q

What is the zymogen form of thrombin?

A

Factor II (Prothrombin)

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6
Q

What is the active protease form of Factor II?

A

Factor IIa (Thrombin)

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7
Q

What is the substrate for Factor IIa (Thrombin)?

A

Fibrinogen (Factor I)

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8
Q

What is the zymogen form of the enzyme activated by tissue factor?

A

Factor VII

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9
Q

What is the active protease form of Factor VII?

A

Factor VIIa

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10
Q

What is the cofactor for Factor VIIa?

A

Tissue Factor (Factor III)

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11
Q

What are the substrates for Factor VIIa?

A

Factor IX and Factor X

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12
Q

What is the zymogen form of the enzyme that requires Factor VIIIa as a cofactor?

A

Factor IX

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13
Q

What is the active protease form of Factor IX?

A

Factor IXa

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14
Q

What is the cofactor for Factor IXa?

A

Factor VIIIa

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15
Q

What is the substrate for Factor IXa?

A

Factor X

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16
Q

What is the zymogen form of the enzyme that requires Factor Va as a cofactor?

A

Factor X

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17
Q

What is the active protease form of Factor X?

A

Factor Xa

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18
Q

What is the cofactor for Factor Xa?

A

Factor Va

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19
Q

What is the substrate for Factor Xa?

A

Factor II (Prothrombin)

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20
Q

What is the zymogen form of the enzyme that activates Factor IX?

A

Factor XI

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21
Q

What is the active protease form of Factor XI?

A

Factor XIa

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22
Q

What is the substrate for Factor XIa?

A

Factor IX

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23
Q

What is the zymogen form of the enzyme that activates Factor XI?

A

Factor XII

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24
Q

What is the active protease form of Factor XII?

A

Factor XIIa

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25
What is the cofactor for Factor XIIa?
High-molecular-weight kininogen (HMWK)
26
What is the substrate for Factor XIIa?
Factor XI
27
What is the zymogen form of kallikrein?
Prekallikrein (Pre-K)
28
What is the active protease form of prekallikrein?
Kallikrein (K)
29
What is the cofactor for prekallikrein activation?
High-molecular-weight kininogen (HMWK)
30
What is the substrate for kallikrein?
Factor XI
31
Which coagulation factor is the substrate in the coagulation cascade?
Fibrinogen (Factor I)
32
Which zymogen is activated into thrombin?
Prothrombin (Factor II)
33
Which factor serves as a cofactor for Factor IXa?
Factor VIIIa
34
Which factor serves as a cofactor for Factor Xa?
Factor Va
35
Which coagulation factor is activated by high-molecular-weight kininogen (HMWK)?
Factor XII
36
What does prekallikrein (Pre-K) activate?
Factor XI
37
What is the preferred name of Factor I?
Fibrinogen
38
What is the preferred name of Factor II?
Prothrombin
39
What is the synonym for Factor III?
Tissue thromboplastin
40
What is the preferred name of Factor IV?
Calcium
41
What is the synonym for Factor V?
Labile factor / Accelerator globulin (aCg)
42
What is the synonym for Factor VII?
Stable factor / Serum prothrombin conversion accelerator (SPCA)
43
What is the synonym for Factor VIII:C?
Antihemophilic factor (AHF) / AHF A / Platelet cofactor 1
44
What is the synonym for Factor IX?
Plasma thromboplastin component (PTC) / Christmas factor / AHF B
45
What is the synonym for Factor X?
Stuart-Prower factor / Stuart factor / Prower factor
46
What is the synonym for Factor XI?
Plasma thromboplastin antecedent (PTA) / AHF C
47
What is the synonym for Factor XII?
Hageman factor / Glass factor / Contact factor
48
What is the synonym for Factor XIII?
Fibrin stabilizing factor / Laki-Lorand factor / Fibrinoligase
49
What is the synonym for prekallikrein (PK)?
Fletcher factor
50
What are the synonyms for high-molecular-weight kininogen (HMWK)?
Fitzgerald factor / Contact activation cofactor
51
Where are most coagulation factors produced?
Liver
52
Which factor complex is not produced in the liver?
Factor VIII complex
53
Which cells produce Factor VIII:vWF?
Megakaryocytes & endothelial cells
54
Which coagulation factors are serine proteases?
II, VII, IX, X, XI, XII, Prekallikrein (PK)
55
Which coagulation factor is a transglutaminase?
Factor XIII
56
Which coagulation factors are cofactors?
III, V, VIII, HMWK
57
Which coagulation factors belong to the contact group?
XII, XI, HMWK, PK
58
Which coagulation factors are Vitamin K dependent?
II, VII, IX, X
59
Which coagulation factors belong to the fibrinogen group?
I, V, VIII, XIII
60
Which coagulation factors are part of the intrinsic pathway?
VIII:C, IX, XI, XII, PK, HMWK
61
Which coagulation factors are part of the extrinsic pathway?
III, VII
62
Which coagulation factors are part of the common pathway?
I, II, V, X, XIII

HEMA 2 LEC (9 decks)

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