3.2 Micro 2

Question 1

Flaviviridae: enveloped? SS or DS, + or - sense? where does it replicate

Answer 1

Enveloped, spherical. Single-stranded, positive-sense linear RNA genome. Replicates in the cytoplasm

Question 2

List the 4 Flavivirdae viruses we talked about

Answer 2

West Nile virus Dengue virus St. Louis encephalitis virus Yellow fever virus

Question 3

what’s the most important arbovirus in N America? What’s the reservoir? Vector

Answer 3

West Nile. Wild birds: reservoir Vector: mosquitos

Question 4

4 YO F in your office just got back from trip to coastal thialand with her parents. Feeling progressively ill; now has severe headache, pain behind the eyes, muscle pain, bone pain and petichial rash. temp of 102.9 measured in your office. Oh man, now she’s vomiting in the trash can! What ails this girl? what’s a crucial part of supportive care?

Answer 4

1. Dengue. 2. must maintain fluid balance

Question 5

If I’m traveling to tropical and subtropical areas in South America and Africa, which live, attenuated aroboviral vaccine would you recommend along with Japanese Encephalitis?

Answer 5

yellow fever

Question 6

where do you usually see Saint Louis encephalopathy? what’s the reservoir?

Answer 6

1.Usually eastern & central U.S.; “urban” 2. wild birds

Question 7

Name the 3 Togaviridae viruses we talked about

Answer 7

Eastern equine encephalitis virus Western equine encephalitis virus Chikungunya virus

Question 8

give me the Togaviridae specs

Answer 8

1. Enveloped, spherical 2. Single-stranded, positive-sense linear RNA genome 3. Replicates in the cytoplasm

Question 9

Your 32 YO country bumpkin pt just got back from a trip to the Okefenokee Swamp (look up where this is if you don’t know) 7 days ago. Now he’s feeling a bit run-down. Somehow you KNOW it’s a wild-bird reservoir based illness. Which one is it? What’s the reservior?

Answer 9

1. Eastern equine encephalitis 2. swamp mosquito

Question 10

Your 2 week-old pt just got back from a trip from Houston training wild pigeons with Mike Tyson. she’s pretty sick with a illness spread by vector, Culex tarsalis. What is the disease? What are her risk factors?

Answer 10

1. Western equine encephalitis 2. infant, west of mississippi river , wild bird reservoir.

Question 11

Chikungunya presentation is similar to Dengue. How can you differentiate the two illnesses?

Answer 11

Chikungunya has more joint pain, not as lethal

Question 12

give me the Bunyaviridae specs

Answer 12

1. Enveloped, spherical 2. Segmented, single-stranded, negative-stranded, (ambisense) linear RNA genome 3.Replicates in the cytoplasm

Question 13

It’s September 1. Your 13 YO male patient just got back from West VA and Chattanooga where he was racing mountain bikes. He said everybody down there was sooooo smart but the mosquitos were awful. This dude’s obviously getting delirious. Based on age, travel locale and time of year, what’s he got?

Answer 13

California encephalitis virus complex

Question 14

give me the Reoviridae specs

Answer 14

1. double capsid structure 2. Naked 3. Segmented, double-stranded, linear RNA genome 4.Replicates in the cytoplasm 5. Reo: respiratory enteric orphan

Question 15

Colorado tick fever virus reservoir, risk factor?

Answer 15

1. Wood tick (Dermacentor andersoni ) is a true reservoir & transmitted transovarially by adult female ticks 2. hiking/camping in Occurs in mountains of western and northwestern U.S. & western Canada

Question 16

What is the difference between a Zoonosis and Epizootic?

Answer 16

Zoonosis: any infection that is transmitted to man from vertebrates.

Epizootic: a disease epidemic in an animal population.

Question 17

What is an arbovirus? Robovirus?

Answer 17

Arbovirus: arthropod-borne virus.

Robovirus: rodent-borne virus.

Question 18

which viruses that we talked about are transmitted by vector, 1. aedes mosquito? 2. culex?

Answer 18

1. Dengue, YFV, CV
2. WNV, SLEV, WEEV