3.2 a clinical approach to autoimmunity

Question 1

what race is lupus most prevalent in?

Answer 1

afro-caribbean
then south asians
then caucasians

Question 2

what is the glove and sweater response in history taking?

Answer 2

ask about symptoms e.g fever, fatigue, weight loss, pain etc in the regions that you pass when you put on gloves and a sweater
so 
- hands
- forearms
- arms
- shoulders 
- head
- neck
- chest
- belly

Question 3

what is significant in the gloves section of the gloves and sweater approach?

Answer 3

raynauds
joint pain and swelling
hand rash

Question 4

what is significant in the sweater section of the gloves and sweater approach?

Answer 4

• proximal muscle weakness
• hair loss (if waking with hair on pillow)
• eyes and mouth dryness
• nosebleeds
• mouth ulcers
• pleuritic chest pain

Question 5

what in your routine bloods would indicate and autoreactive disorder?

Answer 5

high CRP

Question 6

what will a patient need to have to qualify as having lupus?

Answer 6

A RASH POINTS Medical Diagnosis

A = Anti-nuclear antibody (ANA) positive

R = Renal abnormalities (blood+urine on dip)
A = arthiritis/arthralgia
S = serositis 
H = haematological abnormalities

P = photosensitivity
O = oral ulcers
I = immunological abnormalities
N = neurological abnormalities 

M = malar rash

4/11 = definite lupus