3.1.9 Descovery And Development Of Drugs Flashcards

1
Q

Where were drugs traditionally extracted from?

A

Plants and microorganisms like mould

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2
Q

☆ What drugs have been extracted from plants? (3p)

A
  • Digitalis from foxgloves
  • Aspirin from bark of willow trees
  • Penicillin from penicillium mold
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3
Q

Who discovered penicillin?

A

Alexander Fleming in 1928

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4
Q

Where might medicines coke from in the future?(2p)

A
  • synthesised by research chemists
  • extracting chemicals from a plant or microorganism
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5
Q

Characteristic of a good medicine?(3p)

A

-Effective
- Safe
- Stable

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6
Q

Effective medicine

A

Medicine that prevents or cures a disease

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7
Q

Safe medicine

A

Medicine that isn’t too toxic or has bad side effects

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8
Q

Stable medicine

A

Medicine that can be stored easily

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9
Q

Placebo (2p)

A
  • A substance that has no therapeutic effects
  • Is used as a control in testing new drugs
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10
Q

Double blind trial

A
  • When neither the tests subject(human) or the researcher administering the study knows whether the test subject is receiving the experiment treatment or the placebo
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11
Q

Why is ‘double blind’ trial and placebo important to ensure the validity of trial results? (3p)

A
  • Neither party can make expectations on the results
  • Stops researchers from fixing results
  • Ensures that the control and experiment group both experience placebo effect to the same extent
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12
Q

Stages of drug trials (8p)

A

1- Decide which disease to treat
2- Look at natural remedies that already exist and analyse them
3- Synthesise lots of chemical in the lab
4- Screen drugs
5- Test drugs on animals
6- Test drugs on healthy people
7- Test drugs on actual patients
8- Drug is licensed for use by doctors

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13
Q

Why are drug trials expensive (2p)

A
  • Trial and error
  • Thorough research
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14
Q

Phases of clinical trials (3p)

A

1) Healthy humans
2) Some diseased people
3) Lots of diseased people

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15
Q

Phases of preclinical trials? (3p)

A

1) tested on cells
2) tested on tissues
3) tested on live animals

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