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Clinical Pharmacology > 3.1 Hypertension > Flashcards

3.1 Hypertension Flashcards

1
Q

how do we work out mean arterial pressure?

A

cardiac output x total peripheral resistance
or
DBP + (SBP-DBP/3)

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2
Q

what 2 mechanisms do we use to regulate blood pressure?

A

autonomic sympatheitc activity

renin-angiotensin-aldosterone system

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3
Q

what are autocoids and how do they affect the vascular smooth muscle?

A

molecules that act as local hormones such as bradykinin and nitric oxide
act as vasodilators

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4
Q

what is the main determinant of resistance to flow?

A

radius of vessel

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5
Q

how does hypertension affect blood vessels?

A

causes remodelling, thickening and hypertrophy

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6
Q

what can cause vascular remodelling?

A

hypertension

local salt sensitivity

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7
Q

what are some of the pathological consequences of hypertrophy?

A

end organ damage - renal, peripheral vascular disease, aneurysm, vascular dementia, retinal disease
hypertensive heart disease - LVH and dilated heart failure
increased morbidity and mortality
linear relationship with coronary artery disease and stroke

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8
Q

what is hypertension?

A

an elevation in blood pressure that is associated with an increase in risk of some harm
greater than 140/90mmHg

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9
Q

what is the most common cause of hypertension?

A

essential/primary/idiopathic hypertension

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10
Q

how do we increase diagnoses of hypertension?

A
  • Screening those at risk - often hypertensive patients are asymptomatic
  • Increasing public awareness of risk factors
  • Appropriate lifestyle changes to limit risk – no immediate gain presents a challenge.
  • Reliable measurements based on clinical guidelines
  • Regular monitoring and refinement of medication
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11
Q

how do we measure blood pressure to diagnose hypertension?

A
  • Sitting, relaxed and arm is supported. Cuff placed at the level of the heart
  • Both arms, >15 mmHg difference repeat measurement and use arm with higher reading
  • Measurements over period of visits +/- ABPM/HBPM
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12
Q

when is emergency treatment for hypertension advised?

A

> 180 SBP or 120 DBP + clinical signs (retinopathy/headaches/seizures)

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13
Q

what are the target blood pressures in hypertensives?

A
  • 140/90 < 80 years old including type II diabetes
  • 150/90 > 80 years old
  • 135/85 type 1 diabetes
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14
Q

what is the desired BP?

A

120/80mmHg

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15
Q

what is stage 1 hypertension?

A

Clinic blood pressure ranging from 140/90 mmHg to 159/99 mmHg and subsequent ABPM daytime average or HBPM average blood pressure ranging from 135/85 mmHg to 149/94 mmHg.

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16
Q

what is stage 2 hypertension?

A

Clinic blood pressure of 160/100 mmHg or higher but less than 180/120 mmHg and subsequent ABPM daytime average or HBPM average blood pressure of 150/95 mmHg or higher.

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17
Q

what is stage 3 or severe hypertension?

A

Clinic systolic blood pressure of 180 mmHg or higher OR clinic diastolic blood pressure of 120 mmHg or higher.

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18
Q

what is the BP range of prehypertension?

A

> 120/80 <140/90 mmHg

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19
Q

what is the advice given to patients that are prehypertensive?

A
  • Promotion of regular exercise
  • Modified healthy/balanced diet
  • Reduction in stress and increased relaxation
  • Limited/reduced alcohol intake
  • Discourage excessive caffeine consumption
  • Smoking cessation
  • Reduction in dietary sodium
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20
Q

name some primary hypertension therapeutic drugs?

A

• Angiotensin converting enzyme (ACE) inhibitors (ACEi)
Angiotensin (AT1) receptor blockers (ARBs)
• Calcium channel blockers (CCBs)
• Diuretics – thiazide and thiazide-like

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21
Q

where is ACE predominantly found?

A

on the luminal surface of capillary endothelium in the lungs

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22
Q

what are the main receptors of angiotensin-II?

A

AT1 (vasoconstriction)

AT2 (opposes action of AT1)

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23
Q

what are the main actions of AT-II?

A

vasoconstriction
stimulation of aldosterone
cardiac and vascular muscle cell growth
ADH release form posterior pituitary

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24
Q

what are the main actions of ACEi?

A

A reduction in Angiotensin-II activity, resulting in
vasodilation (↓ peripheral resistance →↓afterload)
reduction in aldosterone release (↑Na + H2O excretion)
reduced vasopressin (ADH) release (↑ H2O excretion)
reduced cell growth and proliferation

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25
how can AT-II be produced from AT-I independently of ACE?
via chymases
26
how do ACEi cause vasodilation?
1. reduce angiotensin-II activity that would have caused vasoconstriction 2. Bradykinin is a substrate for ACE. ACEi increase the effects of bradykinin causing vasodilation via NOS/NO and PGI2
27
give some examples of ACEi
lisinopril | ramipril
28
what are the ADRs of ramipril?
``` hypotension dry cough hyperkalaemia cause or worsen renal failure angioedema ```
29
what are the contraindications of ACEis?
Renal artery stenosis, AKD, pregnancy, (CKD - caution), idiopathic angioedema
30
what are the important drug reactions of ACEis?
increasing K+ drugs, NSAIDs, other antihypertensive agents
31
give some examples of ARBSs/ AT1 receptor blockers?
candesartan | lasartan
32
what are some of the ADRs of ARBs?
Hypotension! | hyperkalaemia (low aldosterone ↑K+) cause or worsen renal failure
33
why are ARBs more effective at inhibiting Ang-II mediated vasoconstriction than ACEi?
as angiotensin1 receptor blockers work further down the pathway than ACEi. As chymases can act to still produce AngII in the presence of ACEi, they are less effective.
34
why are ACEi more effective in treating hypertension than ARBs in patients with low-renin?
as still have effects of vasodilation mediated by bradykinin. As ARBs do not effect bradykinin they are less effective in low renin patients?
35
what are some of the contraindications of ARBs?
renal artery stenosis, pregnancy, AKD caution in CKD
36
what is the function of L-type calcium channels
to allow the influx of calcium into cells when stimulated to open by an electric current. allows contraction. also known as voltage gated.
37
where are L-type calcium channels expressed?
in vascular smooth muscle, cardiac myocytes and the Sa and AV node
38
what are the 3 different types of calcium channel blockers and how do they vary?
``` dihydropyridines, non-dihydropyridines (phenylalkylamines and benxothiazapines) each class interact with different sites on (α1) subunit of VOCC - they have different selectivity for vascular smooth muscle or myocardium ```
39
what is the function of dihydropyridines?
to treat hypertension without heart involvement (little chronotropic or inotropic effect). only work by acting on peripheral vasculature
40
what is the function of phenylalkylamines?
act to depress the SA node and slow AV conduction. have a negative inotropic and chronotropic affect
41
what is the function of benzothiazapines?
used to treat hypertension as have some vasodilatory effect on peripheral vasculature aswell as some SA/AV node effects
42
what is the primary choice antihypertensive in low renin patients?
CCBs
43
give some examples of dihydropyridine drugs
amlodipine nifedipine nimodipine
44
when in nimodipine indicated?
nimodipine is a dihydropyridine with cerebral vasculature selectivity. Is useful for ischaemic effects of subarachnoid haemorrhage
45
what are some of the ADRs of amlodipine?
Ankle swelling, flushing, headaches (vasodilation) | Palpitations (compensatory tachycardia)
46
what is the contraindications of dihydropyridines?
unstable angina | severe aortic stenosis
47
what are the important drug interactions of amlodipine?
simvastatin. increases the effect of the statin.
48
give an example of a phenylalkylamine
verapamil
49
what is the mechanism of action of verapamil?
Class IV anti-arrhythmic agent/prolongs the action potential/effective refractory period Less peripheral vasodilatation, negative chronotropic and inotropic effects
50
what is verapamil used for?
arrhythmia angina hypertension
51
what are some of the ADRs if verapamil?
constipation bradycardia heart block cardiac failure
52
what are the drug interactions of verapamil?
beta blockers other antihypertensives antiarrhythmic agents
53
give an example of a benzothiazapine?
diltiazem
54
give an example of a thiazide diuretic
bendroflumethiazide
55
give an example of a thiazide like diuretic
indapamide
56
what is the mechanism of action of thiazide diuretics?
Inhibit N+/Cl- co-transporter in distal convoluted tubule (RAAS compensates with time) Long term effects mediated by sensitivity of vascular smooth muscle to vasoconstrictors Ca2+/NAd
57
when are diuretics indicated in the treatment of hypertension?
in oedema
58
what are the adverse drug reactions of bendroflumethiazide?
Hypokalaemia, hyponatraemia, hyperuricemia (gout), arrhythmia ↑glucose (especially with beta-blockers) small ↑cholesterol and triglyceride
59
what are some of the drug interactions of bendroflumethiazide?
NSAIDs | K+ decreasing drugs such as loop diuretics
60
when are ACEi or ARBs considered first line in treating hypertension?
in patients with type 2 diabetes | in non-black patients under 55 years
61
when is CCB considered the first line in treatment of hypertension?
in patients over 55 years | in black African and black-caribbean patients
62
what is the two pronged effect of treating hypertension with ACEi or ARBs?
decrease peripheral vascular resistance to decrease BP | dilation of the efferent glomerular arteriole to reduce intraglomerular pressure
63
if the patient is still hypertensive after taking a ARB/ACEi + thiazide diuretic + CCB, what is the next step in treatment?
spironolactone - an aldosterone receptor antagonist or alpha or betablockers if high K+
64
what is the adverse drug reactions of spironolactone?
hyperkalaemia | gynaecomastia
65
how does spironolactone cause gynaecomastia?
Spironolactone is a mineralcorticoid antagonist but is not highly selective. Can therefore bind to other steroid receptors such as the testosterone receptor. this down regulates the testosterone production, and increases the conversion of testosterone to oestrogen hence causing breast enlargement
66
give some examples of beta adrenoceptor blockers
labetalol bisoprolol metoprolol
67
what is the mechanism of action of beta adrenoceptor blockers?
decrease sympathetic tone by blocking noradrenaline and reducing the myocardial contraction. reduced CO decreases renin secretion
68
what are the adverse drug reactions of beta adrenoceptor blockers?
Bronchospasm, heart block, Raynaud’s (cold hands), lethargy, impotence Mask tachycardia – sign of insulin induced hypoglycaemia
69
what are the drug interactions of beta blockers?
the non-dihydropyridine CCbs - verapamil and diltiazem = asystole
70
what are the contraindications of beta blockers?
asthma copd haemodynamic instability hepatic failure
71
give an example of an alpha adrenoceptor blocker
doxazosin
72
what are the indications of alpha 1 adrenoreceptor blockers?
hypertension - reduced peripheral vascular resistance (doxazosin) benign prostatic hyperplasia (tamsulosin)
73
what are the adverse effects of alpha1 adrenoceptor blockers?
Postural hypotension | dizziness, syncope, headache and fatigue
74
what is CO in a healthy adult?
5L/min
75
what variables affect cardiac output?
preload – filling pressure afterload – “load” that ventricle must eject blood against contractility heart rate
76
what are the common symptoms of heart failure?
exercise intolerance dyspnoea fatigue
77
how does cardiac failure cause remodelling?
1. decreased Bp is detected by the baroceptors causing a neurohormonal response - there is proliferative signalling of ANG-II, NAd, Aldosterone which increase RAAS and sympathetic drive. this damages the cardiac tissue over time causing remodelling 2. sympathetic NS and RAAS increase vasocontriction and blood volume. This increases the preload and afterload and therefore the work of the heart resulting in remodelling
78
what are the 3 main steps in the management of heart failure?
1. correct underlying cause - angioplasty/ valve replacement 2. non pharmacological management - decrease salt intake and liquid reduction 3. addition of diuretic plus other therapeutic agents
79
what are the aims of treatment of heart failure?
heart failure cannot be sured so current treatments are supportive and focus on: • reduction in symptoms (dyspnoea, fatigue, oedema) • managed increase in exercise tolerance • address arrhythmias, hyperlipidaemia, diabetes • increase quality of life and slow morbidity
80
what are the steps of drugs given in heart failure?
1. loop diuretic (furosemide) to reduce signs of volume overload - dyspnoea and peripheral oedema 2. offer ACEi (lisinoprila and ramipril) to reduce sympathetic output, vasodilation and water retention and add BB ( bisoprolol) to reduce remodelling and improve systolic function 3. mineralcorticoid agonist (spironolactone) - decrease preload and afterload to improve CO 4. consider ARB if intolerant to ACEi

Clinical Pharmacology (26 decks)

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