3. Pharmacodynamics Flashcards
phamacodynamics
what the drug does to the body
4 types of pharmacodynamic process
- receptors
- ion channels
- enzymes
- transporters
how drugs can affect ion channels (2)
- block (it going through membrane)
2. modulate (increase/decrease chance of it opening)
how drugs can affect enzymes (3)
- inhibit enzyme action
- act as a false substrate
- pro-drug (converted to active product)
Transporters
proteins that actively transport substances across membranes against their concentration gradient
how drugs can affect transporters (2)
- alter permeability
2. inhibit carrier molecule
Affinity
the ability of the drug to bind to receptors
efficacy
the relationship between receptor occupancy and the ability to initiate a response
potency
the concentration of drug needed to produce a particular response
dose response curve
amount administered to the response
agonists
can be naturally occurring or endogenous substances/messangers
Three types of agonists
- partial agonists
- full agonists
- inverse agonists (decrease level of response induced by endogenous agonists)
Competitive antagonism (2)
- reversible (summountable, parallel shift, no decrease in max)
- irreversible (not surmountable, no parallel shift, decrease in max)
Non competitive antagonism
antagonist blocks chain of events that leads to the response usually produced by the agonist
–> does not actually compete for site of action of agonist
MUST REMEMBERRR! (random facts)
agonist
binds to and activates a receptor
