3. LA Complications Flashcards
Features of lignocaine/lidocaine (4)
Amide
Standard - lidocaine HCl 2%
Vasoconstrictor - none/adrenaline (1:80,000)
Features of prilocaine/citanest (3)
Amide
Standard - prilocaine HCl 3%
Vasoconstrictor - plain/felypressin (octapressin - 1.2ug)
Features of articaine (4)
Amide
Standard - 4% with varying vasoconstrictor (1:100,000, 1:200,000, 1:400,000)
Uses - infiltration and blocks
Useful if patient has liver disease
Length of action of mepivicaine (3)
Infiltration - 20mins
Block - 40mins
Soft tissue - 2hrs
Length of action of lignocaine (3)
Infiltration - 60mins
Block - 90mins
Soft tissue - 3-5hrs
Length of action of articaine (3)
Infiltration - up to 120mins
Block - 75mins
Soft tissue - 3-5hrs
Length of action of prilocaine (3)
Infiltration - 30-45mins
Block - 60mins
Soft tissue - 3-6hrs
Systemic complications of LA (6)
Psychogenic/stress Interactions with other drugs Cross infection Allergy Collapse Toxicity
Psychogenic/stress includes (7)
Fainting Palpitations Cold sweat Restlessness Excitation Trembling Weakness
Cause of psychogenic/stress
Lack of oxygenated blood to the brain
Clinical features of psychogenic/stress (6)
Light-headedness Pallor Beads of sweat (lips/nose/temple) Bradycardia (slow pulse) Nausea Pupil dilation
Management of psychogenic/stress (4)
Lay flat and raise legs
Loosen neck clothing
Improve room ventilation
Sweet drink potentially
LA interactions with other drugs (5)
MAOI (mono amine oxidase inhibitors) Tri-cyclics (theoretical risk of HTN) B-blockers (BP increase_ Non-K sparing diuretics (adrenaline lowers K too) Cocaine (increased adrenergic activity)
Features of LA allergy (2)
True allergy is rare
Most allergies are due to preservatives (methylparaben)
Toxicity features (4)
Convulsions
Loss of consciousness
Respiratory depression
Circulatory distress
LA and pregnancy (2)
Avoid octapressin (prilocaine) Has potential to induce labour
Max. safe dose of mepivicaine, 3% (3)
Max dose - 3mg/kg
66mg/cartridge
6cartridges/70kg adult
Max. safe dose of lignocaine, 2% (3)
Max dose - 5mg/kg
44mg/cartridge
7cartridges/70kg adult
Max. safe dose of articaine, 4% (3)
Max dose - 7mg/kg
88mg/cartridge
5cartridges/70kg adult
Max. safe dose of prilocaine, 3% (3)
Max dose - 8mg/kg
66mg/cartridge
8cartridges/70kg adult
Adrenaline effects on B1-receptors (5)
Increase HR Increase force of heart contractions Increase CO Increase heart muscle excitability Dilation of coronary BVs
Adrenaline effects on B2-receptors (2)
Relaxation of bronchial smooth muscle
Muscle dilation
Adrenaline effect on a-receptors
Skin contraction
Adrenaline effects on BP (3)
Increases systolic BP
Decreases diastolic BP
Overall little effect on BP
Adrenaline contraindications (4)
CVD
Hyperthyroidism (thyroid crisis)
Phaeochromocytoma (HTN)
Drug interactions
Adrenaline action (3)
Works by redirecting blood flow (to heart, liver, skeletal muscle from non-essential organs during fight/flight)
Binds to B2 receptors causing vasodilation
Binds to a1 receptors causing vasoconstriction
Local complications of LA (12)
Failure to achieve anaesthesia Prolonged anaesthesia Pain during/after injection Trismus (lockjaw) Haematoma Intra-vascular injection Blanching Facial paresis (weakness) Broken needle Infection Soft tissue damage Contamination
Types of prolonged anaesthesia (3)
Direct trauma from needle
Multiple passes with same needle
Chemical trauma from direct injection
Facial palsy presentation
Usually complete, unilateral nerve paralysis within minutes of IDB
Facial palsy confirmation
Temporal branch affected (lower MND)
Facial palsy cause
LA into parotid gland (injection too far posteriorly)
Facial palsy diagnosis
Test branches of CNVII
Facial palsy management
Reassurance, cover eye with paid until blink reflex returns
Types of intra-vascular injection (2)
Intra-arterial
Intravenous
Features of IA injection (5)
Rare Skin blanching Visual disturbances Aural disturbances Transitionary, but persistence requires rapid specialist referral
Features of IV injection (3)
Block injections (IDB) Avoided by careful technique (aspiration) Palpitation, anxiousness, restlessness, headache, sweating, pallor