(3) Intro to Neoplasia I (Putthoff)

Question 1

Cancer is the name for all tumors, benign and malignant

A. Yes

B. No

C. It depends

Answer 1

Cancer is the name for all tumors, benign and malignant

A. Yes

B. No

C. It depends

Question 2

Tumors can always be categorized as benign or malignant

A. Yes

B. No

C. Never

Answer 2

A. Yes

B. No

C. Never

Question 3

Cancer is said to be genetic, therefore most cancers are inherited

A. Yes

B. No

C. Never

Answer 3

A. Yes

B. No

C. Never

Question 4

Cancer cells are often said to be immortal, therefore all cells in a malignant clone, are immortal

A. Yes

B. No

Answer 4

A. Yes

B. No

Question 5

Cancer (malignant transformation of cells) occurs (at its common sites, eg lung, breast, colon) from differentiated surface cells.

A. Yes

B. No

C. Sometimes

Answer 5

A. Yes

B. No

C. Sometimes

Question 6

Some benign tumors metastasize

A. Yes

B. No

Answer 6

A. Yes

B. No

Question 7

What is a metastasis?

Answer 7

The spread of cancer cells from their primary site (the tissue in which the cancer began) to another site in the body

Question 8

T/F

Contigous spread does constitute metastasis

Answer 8

F

Question 9

What are the most common sites for cancers to metastasize?

Answer 9

LLBB

Liver, lungs, bone and brain

Question 10

What are examples of some causes of cancer?

Answer 10

Genetics

Tobacco

Diet/Physical Activity

Sun/UV exposure

Radiation exposure

Question 11

What is the most prevalent cancer in males vs females?

Answer 11

Males = prostate

Females = breast

Question 12

What are these samples examples of?

Answer 12

Metastatic breast cancer

(Common ductal carcinoma of the breast)

Question 13

Basic Definitions: Cancer and Neoplasia

Define:

Cancer

Answer 13

Generic term for all malignant neoplasms

Question 14

Basic Definitions: Cancer and Neoplasia

Define:

Neoplasia

Answer 14

“New growth or form”

Question 15

Basic Definitions: Cancer and Neoplasia

Define:

Tumor

Answer 15

Used by physicians as a synonym for neoplasia

Question 16

Basic Definitions: Cancer and Neoplasia

Define:

Oncology

Answer 16

Study of tumors (neoplasms)

Question 17

Basic Definitions: Cancer and Neoplasia

Define:

Clonal

Answer 17

The entire population of a neoplasm arises from a single cell that has incurred genetic change

I.e., all neoplastic cells are clones of one original altered cell

Question 18

Every time DNA is copied, about ___ random mutations occur

Answer 18

3

Question 19

MOST cancers are the result of….

Answer 19

Sporadic maligant neoplasm

Question 20

What are the most common primary tumors/cancers in western society?

Answer 20

Skin

Lung

Large bowel

Prostate

Breast

Question 21

Cancer occurs from surface cells in the epithelium

A. Yes

B.No

C. Sometimes

Answer 21

A. Yes

B.No

C. Sometimes

Question 22

Answer 22

E

Question 23

What is this an example of?

Answer 23

Basal cell carcinoma

Question 24

Cancers do NOT arise from…

Answer 24

De-differentiation of adult cells

Question 25

What are examples of common names of **benign** tumors?

Answer 25

Adenoma Papilloma Cystadenofibroma

Question 26

What is the greek derived term used to describe **malignant tumors?**

Answer 26

*Sarcomas*

Question 27

Malignant tumors arising from **blood-forming cells** are called...

Answer 27

Leukemias or Lymphomas

Question 28

What are the three major categories of **malignant** cancers?

Answer 28

Carcinomas Sarcomas Blood forming cells

Question 29

What is the most common general category of malignant tumors in US adults?

Answer 29

Carcinoma

Question 30

What is this an example of?

Answer 30

Mixed tumor

Question 31

What is this an example of?

Answer 31

Teratoma

Question 32

What are the two general components of tissue?

Answer 32

Parenchyma Stroma

Question 33

What is the **parenchyma?**

Answer 33

Gives rise to the neoplastic cellular component, it is **benign, malignant or "other"**

Question 34

What is the stroma?

Answer 34

The supportive cellular component (The tissue "skeleton" upon which (or within which) the parenchymal component resides)

Question 35

What is a gland?

Answer 35

A group of cells, frequently arranged **around a lumen** The cells are typically specialized to secrete a **substance**

Question 36

What is cellular "atypia"?

Answer 36

Cell has "atypical" structure from normal Cancerous cells demonstate: Small cytoplasm Multiple nuclei Multiple and large nucleoli Coarse chromatin

Question 37

# Define: Metaplasia

Answer 37

Replacement of one type of cell with another type

Question 38

# Define: Dysplasia

Answer 38

Disordered growth

Question 39