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Immuno Unit 3 Self > 3 Humoral Immunity I > Flashcards

3 Humoral Immunity I Flashcards

1
Q

T-F—each mature B cell clone in the periphery expresses only one type of antibody?

A

True

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2
Q

T-F—in a typical infection there are many B cells that can bind to a single antigen in the periphery?

A

False—few

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3
Q

What is the difference between a B-1a cell and B-1b cell markers?

A

B1-b does not have CD5

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4
Q

What is the difference between marginal zone B-2 cells and Follicular B-2 cells markers?

A

Marginal zone does not have CD23

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5
Q

Are many B-1 cells produced in the adult?

A

No–few…most are generated in fetus and neonate liver and bone marrow

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6
Q

Can B-1 cells self renew in the periphery?

A

yes

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7
Q

Are many B-2 cells produced in the fetus?

A

No- some, FO B cells in the neonate but are produced continuously throughout life in bone marrow

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8
Q

Are marginal zone B cells present at birth in the periphery?

A

No

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9
Q

T-F–rearrancged heavy chains contain only a subset of Vh elements present in germ line? What does it mean?

A

True- antibodies produced by B-1 B cells tend to bind certain types of macromolecules

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10
Q

Where do B-1 cells primarily localize?

A

to serous body cavities–lung pleura and peritoneal cavity

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11
Q

Are B-1 cells present in large numbers in the spleen and lymph nodes?

A

No

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12
Q

What cells are a main source of Natural IgM?

A

B-1 cells spontaneously produce without infection

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13
Q

What are the 2 distinct B 2 subsets?

A

marginal zone and follicular

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14
Q

What is the antibody repertoire biased towards recognizing in MZ cells? Where does MZ localize?

A
  • microbial products

- white puple marginal zone of spleen.

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15
Q

Where does FO B cells localize?

A

follicles in spleen and lymph node—it is the most abundant B cell subset

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16
Q

Activated follicular B cells migrate where?

A

toward T cell zones to interact with helper T cells

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17
Q

What are marginal zones exposed to?

A

Red pulp–exposed to antigens in blood stream and will secrete IgM into blood stream

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18
Q

Does BCR have an intrinsic signaling ability?

A

No

19
Q

What connects antibody to intracellular signaling pathways?

A

CD79alpha

Cd79beta

20
Q

What coreceptor molecles amplify signals of Ig alpha/beta?

A

CD19, CD,1, CD81

21
Q

What is signal 1 of the B cell activation?

A

engagement of multiple BCRs

22
Q

What is signal 2 of the B cell activation?

A

Provided by an innate receptors or CD4 T cells

23
Q

What is signal 3 of the B cell activation?

A

cytokines produced by neighboring interacting cells

24
Q

Signal 1 alone causes?

A

cell deletion or anergy

25
Q

What does the need of 3 signals create?

A

dependence on activation of other cell types to safeguard against spurious antibody responses

26
Q

What does TD stand for in a TD response?

A

thymus dependent–thus require CD4 help

27
Q

Are TD responses operating in later or earlier stages of immune response?

A

Later

28
Q

Does TD response generate high affinity antibodies?

A

yes

29
Q

Does TD establish long term immunity as elicited by infection or vaccination?

A

Yes

30
Q

Are there more or less magnitude of TI responses than TD responses?

A

Less—and contribute little to long term humoral immunity

31
Q

What are TI responses induced by?

A

polymeric complexes containing repetitive structures

32
Q

What type of antibodies typically come from TI response?

A

IgM

33
Q

What is the key benefit of TI response?

A

source of antibodies in early stages of immune response

34
Q

When are TI responses not effective? Why

A

in the neonate–marginal B cell compartment is poorly developed

35
Q

What type of TI antigen–polymers displaying repeating copies of epitopes that can engage multiple B cell receptors on a single cell?

A

Type 1 antigen [signal 1]

36
Q

What type of TI antigen–contain a component that can directly activate patter recognition receptors?

A

Type 1 TI antigen [signal 2]

37
Q

What type of TI antigen- polymers displaying repeating copies of epitopes that can engage multiple B cell receptors on a single cell?

A

Type 2 TI antigen [signal 1]

38
Q

What type of TI antigen- does not inherently contain a means to provide a second signal?

A

Type 2 TI antigen

39
Q

What type of TI antigen- able to recruit innate components (complement)/

A

Type 2 TI antigen [signal 2]

40
Q

Is lipopolysaccharide a type1 or type 2 antigen? can they be whole cells, aggregates and debris?

A

type 1 TI antigen, yes

[forms BCR complex and can engage TLR4, and elicits cytokine production from innate cells…all 3 signals]

41
Q

What displays LPS on surface?

A

Gram negative

42
Q

Are polysaccharides an example of a type II TI antigen?

A

Yes- provides signal 1 but not signal 2

43
Q

TI responses are mounted primarily by >? why?

A

B-1 and Marginal Zone B cells
[Why? repertoire is enriched for reactivity against microbial antigens, their anatomic location facilitates, biochemically wired for rapid response]

Immuno Unit 3 Self (3 decks)

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