3. Equipment and Physics Flashcards

1
Q

Who first studied nerve stim

Who first used it to perform block

How were nerves blocked prior to this

A

Electrical nerve stimulation was first studied
by French physiologist Louis Lapicque in 1909.

It was first used to perform nerve blocks by
Von Perthes in 1912.

Before this, nerves were blocked by
direct instillation of local anaesthetics
(by dissection and exposure of nerve plexus) or paresthesia techniques.

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2
Q

Nerve stim

How does the technique work

A

The technique of electrical nerve stimulation

is based on the premise

that a current of sufficient amplitude
applied for a sufficient time will
depolarise a nerve.

In the case of nerve blocks,
this means either motor response
or sensory stimulation (since most nerves are
mixed).

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3
Q

Which is more commonly stimulated Motor or sensory

What does the Cathode do

What does the Anode do

A

However, it was also noted that stimulating

motor fibres was easier

than sensory fibres,

and more importantly,

application of a cathode
depolarised the nerve,

while an anode hyperpolarised the nerve.

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4
Q

What does the Cathode do

What does the Anode do

A

application of a cathode

depolarised the nerve,

while an anode
hyperpolarised the nerve.

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5
Q

What is the gold standard

A

At present,

ultrasound guidance is becoming more popular,

but electrical nerve stimulation is
still the commonest method employed.

However, no method of nerve blockade is described as gold standard.

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6
Q

What is Rheobase

A

Rheobase

is the minimum current of

indefinite duration required

to depolarise a nerve.

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7
Q

How do we calculate the total charge required to depol nerve

A

The total charge (Q) required to depolarise a nerve is

the product of the current intensity (I) 
\+
the duration (t) for which it is applied.
Q = I × t
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8
Q

What current intensity is required for depolarisation

A

In turn,
the current intensity
required to produce depolarisation

is given by the following equation

(where Ir is the rheobase
and C is the chronaxie):

I = Ir × (1 + C/t)

t = infinity, we get I = Ir, and so Q = Ir.

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9
Q

what is Chronaxie

A

Chronaxie is the minimum duration

of current twice the rheobase required

to stimulate a nerve

(as shown in the previous answer).

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10
Q

Chronaxae related how to fibre size

A

It is inversely proportional to
fibre size and
hence ease of stimulation.

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11
Q

What is the Chronaxiae of Aa fibres

A

Aα (motor) has a
chronaxie of 0.05–0.1 millisecond,

Aδ (sensory) is 0.15 millisecond
C (unmyelinated sensory) 0.4 millisecond

Hence, stimulating motor nerve
requires shorter pulses than sensory fibres.

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12
Q

Desirable properties of electrical
nerve stimulation are

x 5

  • the most important
A
  1. Short pulse width:
  2. Square-wave current
  3. Cathodal stimulation
  4. Constant current generator * most important
  5. Frequency: 2hz
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13
Q

Short pulse width

Refers to

Why is this advantageous

A

pulse width refers to the time duration
for which the current is applied.
Shorter pulse width has two advantages:

1 Since the motor fibres have 
a smaller chronaxie, 
shorter pulse width
stimulates them 
but not the sensory fibres. 

This results in motor responses
but not painful paresthesia,
which is undesirable anyway.

2 Shorter pulse width may be superior
to longer in estimating needle to- nerve distance

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14
Q

Square-wave current

A

Slow rising current allows

for accommodation

(resulting in difficulty in nerve stimulation)

of nerve fibres.

This can be avoided by the
square-wave form of applying
current (abrupt rise and abrupt fall).

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15
Q

Cathodal stimulation

A

Cathodal stimulation:

it is preferable to stimulate
the nerve with needle as cathode,

since this then depolarises it,

whereas needle as anode
hyperpolarises the nerve

(necessitating application of higher
current for stimulation).

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16
Q

Constant current generator

A

Constant current generator (not fixed):

a peripheral nerve
stimulator (PNS) should 
deliver the same current 
despite changing
impedance applied. 

This is the most important property of the
peripheral nervous system (PNS).

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17
Q

Frequency:

A

Frequency:
a stimulation frequency of
2 Hz is better than 1 Hz,

since it allows
faster manipulation of needle.

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18
Q

Describe important things during PNS

Negative

Positive

Distance between

Current

A

During nerve stimulation,
the following things are vital:

  1. Negative (cathode) to needle.
  2. Positive (anode) to patient.
  3. It was considered that the anode
    site should be at least 20 cm away
    from the needle site to reduce direct muscle stimulation, but this has
    been found to be unnecessary.
4. 
Acceptable current is between 0.2 and 0.5 mA. 
Above 0.5 mA, the needle 
may be further away from the nerve, 
and such injections may
not be successful. 

Below 0.2 mA, injection may be intraneural.

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19
Q

components of a peripheral nerve stimulator

A

Microcontroller

Constant current generator
(most important)

Oscillator

Clock reference

LCD display

Controls

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20
Q

components of a peripheral nerve stimulator

Explained

A
  1. Microcontroller
    Brain of the peripheral nervous system:
    processes variable, like
    current, pulse width, frequency
  2. Constant current generator
    (most important)
    Generates the same current despite changing impedance

3 Oscillator
Generates the desired frequency

4.
Clock reference
Synchronises the current with the frequency

  1. LCD display
    For current amplitude, frequency and the pulse width selected

6Controls
For selecting parameters

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21
Q

appropriate settings of a PNS

for performing a nerve block include

A
  1. negative lead to needle

2.
positive lead to patient

3.
a square-wave impulse (to prevent accommodation)

  1. pulse duration 0.1 millisecond (for stimulating motor nerve fibres preferably)

5.
frequency of 2 Hz (better than 1 Hz)

  1. an initial current of 1–2 mA

7.
a final current of 0.2–0.5 mA
(> 0.5 mA, the needle may be further
away from the nerve,
and such injections may not be successful;
< 0.2 mA, the injection may be intraneural)

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22
Q

What is the law that governs the

principle of nerve stimulation

A

The current required is
inversely proportional
to the square of the distance
between the needle and the nerve

Coulombs

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23
Q

Coulombs Law

A

The inverse-square law (Coulomb’s Law)
dictates that the current required

(I) to stimulate a nerve,
is proportional to the minimal current (i),
and
inversely to the square of the distance (r)

from the nerve (k is a constant)
.
I = k(i/r2)

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24
Q
How may nerve stimulation be altered in 
elderly, 
diabetics or 
those with
neurological diseases,
A
Usually, 
a motor response between 0.2 and 0.5 mA 
is sought and considered appropriate. 
However, 
in elderly, 
diabetics 
or those with neurological diseases, 

higher currents may be needed due to slower
nerve velocities and lower motor amplitudes.

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25
Q

What is the Raj test

How is it performed

What does it confirm

Explain the mechanism

A

The disappearance of the
motor response induced
by a low current (0.5 mA)
following injection of local anaesthetics
or normal saline (conducting solutions),

confirms the proximity of needle to the
nerve and constitutes the Raj test.

This does not result due to the
physical displacement of the nerve
but due to the dissipation of
current density near the nerve.

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26
Q

What is the Tsui test.

How is it performed

What does it confirm

A
The exaggeration of 
motor response induced 
by a low current (0.5 mA)
following injection of 5% dextrose 
(non-conducting solutions),

confirms the needle-to-nerve
proximity as well
and constitutes the Tsui test

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27
Q

Is a sensory response able to elicit a motor response

A

a lack of motor
response does not rule
out the possibility of sensory nerve
contact by the injection needle

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28
Q

Peripheral Nerve Stimulators

  1. Optimal Range
A

Optimal range for a PNS is 0–5 mA.

This is because some patients
may need higher current for stimulation
(diabetics, elderly, neurologic disease).

Newer devices may have higher ranges (0–10 mA) used for epidural stimulation.

Higher ranges (0–80 mA) are used in
neuromuscular monitors.
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29
Q

Peripheral Nerve Stimulators

Percutaneous nerve stimulation

A

Percutaneous nerve stimulation is a
new technique involving the

stimulation of nerves non-invasively.

The current needed for this is
higher than invasive stimulation, 
but offers the identification of
insertion points in 
especially difficult cases (obese).
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30
Q

What range should the PNS be checked in.

A

Biomedical engineering departments
have measured the accuracy of
PNS in the higher current ranges (> 1 mA) in the past.

It was subsequently argued that 
since the current used for 
performing nerve blocks is in the 
range of 0.2–0.5 mA, 
it is prudent to check the 
accuracy in this range. 
This has been adopted by some manufacturers
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31
Q

Which are more accurate insulated or non

A

Non-insulated needles were the
first to be used.

Both the tip and the shaft
were conductive,

causing current dispersion
and lower accuracy.

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32
Q

What is an issue with non insuated needles

A

They also caused local muscle
stimulation through the
shaft of thenneedle.

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33
Q

What are insulated needles coated in

Why are they beneficial

A

The development of Teflon-coated
insulated needles resulted in
better precision.

This is because only the tip is conductive,
and hence the current is not dispersed.

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34
Q

What type of needle tips are available

A

Various needle-tip designs are prevalent.

Among the sharp needles,
the tip may have a
long (standard, 15°) bevel
or short (30° or 45°) bevel

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35
Q

Which bevel cuts nerves

Which bevel causes blunt trauma

A

The long-bevel needles may
cause sharp cuts on nerves,
while the short bevel
leads to blunt nerve damage.

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36
Q

Which type of needle bevel is more frequently associated with injury

Which is more severe

A

Although nerve injury is
more frequent with long-bevel needles,

it may be more severe if it occurs u
sing a short-bevel needle.

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37
Q

Which bevel is used more frequently these days

A
Blunt-bevel needles offer 
more resistance as they pass 
through tissue planes 
and 
thus give a better feel. 

Hence they are most commonly
used nowadays

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38
Q

Needle gauge is an important consideration while performing blocks

Superficial injections

A

Needle gauge is an important consideration while performing blocks.

Superficial injections are
best given using 25/26-G needles.

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39
Q

Needle gauge is an important consideration while performing blocks

Single shot injections

A

The 21/22-G needles are best for single-shot injections,

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40
Q

Needle gauge is an important consideration while performing blocks

Continuous catheter injections

Catheter size

A

18/19-G Tuohy-tip needles
are best suited for
continuous catheter techniques.

In such cases, 20-G
catheters are used.

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41
Q

Needle length is an

A

consideration when doing nerve blocks.
Shorter needle may not be sufficient, while longer needles may have potential
for tissue damage if introduced further than needed

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42
Q

25 mm

what block

A

Interscalene

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43
Q

50 mm

what block

A

Cervical plexus

Supraclavicular

Axillary

Femoral

Popliteal (posterior)

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44
Q

100 mm

A

Infraclavicular

Popliteal (lateral)

Paravertebral

Lumbar plexus

Sciatic (posterior)

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45
Q

150 mm

A

Sciatic (anterior)

46
Q

An in-line pressure-monitoring

provides

A

An in-line pressure-monitoring
device measures pressure while
injecting local anaesthetic.

It provides an objective
assessment of pressures
rather than subjective feel.

The latter can vary between
individuals and devices.

I

47
Q

Intraneural injection pressures

Perineural

A

Intraneural injection pressures are
>20 psi while

those made perineurally
have lower pressures of 5–20 psi.

Therefore, the device guides
placement of the tip according to injection pressures.

48
Q

The continuous catheter technique involves

2 elements and sizes

A

The continuous catheter technique involves

the use of larger needles

(Tuohy-, Sprotte- or facet-tipped 18/19 G)

and fine stimulating catheters (20 G).

Once a nerve is stimulated using the needle, the
catheter is threaded through the needle.

49
Q

In the case of non-stimulating catheters,

how is this done

A

In the case of non-stimulating catheters,

the perineural space is dilated
by injecting saline and threading
the catheter 3–5 cm beyond the
needle tip.

50
Q

Benefit of Catheters

How were they limited

A

Although the use of catheters
helped to prolong postoperative
pain relief,

they were limited by secondary block failures

(primary block refers to the block
following initial injection,
while secondary block is one following continuous infusion).

51
Q

How was secondary failure improved

A

This was improved by stimulating catheters.

They are threaded
along the nerve,

and their position confirmed using
electrostimulation in real time.

This is followed by initial bolus
and continuous infusion,
both through the catheter.

This has reduced secondary failures.

52
Q

‘catheter over needle’

and

‘catheter through needle’

Which is more frequently used
which has a problem with leakage
why

A
Systems with 
‘catheter over needle’ 
and 
‘catheter through needle’ 
are available. 
Though the latter are more prevalent,
their use is often
plagued by leakage through 
the injection site 
(because the hole made 
by the needle is larger than the catheter size).
53
Q

Tunnelling the catheter

A

reduces the chances of dislodgement and helps maintain the

catheter for a longer time.

54
Q

Ultrasound waves are

Beyond what
which is

Clinical U/S are what freq

A

(> 20 KHz) are waves

beyond the audible frequency

range of audible sound
(20–20 000 Hz).

Clinically used ultrasound is in the 1–20-MHz frequency range.

55
Q

Describe how an US Probe works

A

Ultrasound waves are generated by

applying an electric field
to
piezoelectric crystals

to produce a
series of pressure waves.

The pressure waves are transmitted 
from the probe head 
and 
reflected back 
dependent upon the tissue type.

The returning pressure waves are
detected and generate an electric current
that is converted
into a two-dimensional image.

This interpretation assumes the speed of
sound in soft tissues to be 1540 m/second.

56
Q

The speed of sound in soft tissues

A

The speed of sound in soft tissues to be 1540 m/second.

57
Q

The various modes of ultrasound in use are:

A

A Mode

B Mode

M Mode

Doppler mode

58
Q

A-mode:

A

A-mode:
the simplest type of ultrasound.

A single transducer scans
a line through the body with
the echoes plotted on screen as a
function of depth.

59
Q

B-mode:

A

B-mode:
the commonest mode.

A linear array of transducers
simultaneously scans a
plane through the body

that can be viewed as a
two-dimensional image on screen.

60
Q

M-mode:

A

M-mode:
M stands for ‘motion’.

Ultrasound pulses are emitted
in quick succession,

recording a video in ultrasound.

This can be used to determine

the velocity of specific organ structures
such as
cardiac valves and jets

61
Q

Doppler mode:

A

Doppler mode:

This mode makes use of the Doppler effect

(change in frequency 
of a wave for 
an observer moving 
relative to the source
of the wave) 

in measuring and visualising blood flow.

62
Q

What type of waves are US waves

What are their properties

A

Ultrasound waves are sound waves

Wavelength (λ)

Amplitude (A)

Frequency (f)

Period (τ)

Velocity (c):

63
Q

Wavelength (λ):

A

Distance between two consecutive corresponding

points of the same phase.

64
Q

Amplitude (A)

A

maximum height of the wave.

65
Q

Frequency (f)

A

number of complete cycles per second.

66
Q

Period (τ):

A

time taken for one complete wave cycle to occur.

67
Q

Velocity (c):

Calculted how

A

speed at which sound waves
pass through a medium. It
may be calculated using the equation: c = λ × f

68
Q

What is relationship between wavelength and frequency

why

A

wavelength and frequency
bear an inverse relationship.

Since the velocity within a medium is constant,

69
Q

How does frequency affect image quality

high

A

Higher-frequency beams
experience more attenuation

(directly proportional)

and hence have lesser penetration.

They are used for performing 
superficial blocks (interscalene and supraclavicular).
70
Q

How does frequency affect image quality

Low

A

Low-frequency beams have
better penetration and allow

visualisation of deep structures
(infraclavicular and sciatic nerve blocks).

71
Q

Linear probes generate

Curved generate

A

Linear transducers generate high-frequency ultrasound,

while curved array
probes low-frequency ultrasound.

72
Q

Linear array

freq
ax res
attenuation
depth
image
best
A

Linear array

High frequency (6–13 MHz)
Greatest axial resolution
More attenuation
Limited depth of penetration
Rectangular images
Best for superficial structures (e.g.
brachial plexus)
73
Q

Curved array

freq
ax res
attenuation
depth
image
best
A

Curved array

Low frequency (2–5 MHz)
Decreased axial resolution
Less attenuation
Deeper penetration
Sector-shaped image
Best for large or deep structures
(e.g. sciatic nerve)
74
Q

Phased array

freq
ax res
attenuation
depth
image
best
A

Phased array

Consists of many small
ultrasonic elements
High-resolution beam
Characteristic image is
sector-shaped
Used for echocardiography
75
Q

J-shaped

A

J-shaped (hockey-stick footprint)
probes are linear array probes

which are small in size

hence ideally suited for paediatric usage.

76
Q

Axial resolution

A

Axial resolution is the ability

of the system to display small structures

along the axis of the beam

as separate from each other.

It is
directly proportional to the
frequency of the beam.

77
Q

Lateral resolution

A

is the ability of the system to
display small structures
side by side (same depth)
as separate from each other.

78
Q

Attenuation is

What does it cause

A
The sum total of 
reflection, 
refraction, 
scattering 
and
absorption

It leads to
loss of clarity of the image.

79
Q

How can attenuation be corrected

A

It can be corrected
by time-gain compensation

(also called depth-gain compensation).

Attenuation is directly proportional
to the frequency.

So higher frequency
ultrasound beams
undergo higher attenuation
and

allow the best visualisation of superficial structures.

80
Q

What is an artefact

What are the diff types artefact
x4

A

An artefact
is an image,
or part of it,
that does not correspond

to the anatomy of the
structure being examined.

Shadowing
Post-cystic enhancement
Reverberation
Anisotropy

81
Q

Shadowing

A

Shadowing:

when the ultrasound beam
cannot pass through a structure
(e.g. bone),

the beam is reflected back
and the tissues immediately
behind the structure appear dark.

82
Q

Post-cystic enhancement

A

Post-cystic enhancement:

when the ultrasound beam passes
through a fluid-filled structure

such as the
urinary bladder,
cysts or blood
vessels,

very little is reflected,

and therefore the tissues behind the
fluid appear bright.

83
Q

Reverberation

A

Reverberation:

occurs when ultrasound is repeatedly reflected
between two highly reflective surfaces.

84
Q

Anisotropy

A

Anisotropy:

is the property of
tendons, nerves and muscles

to vary in their ultrasound
appearance depending on the
angle of insonation of
the incident ultrasound beam.

85
Q

what is echogenicity

A

On returning to the transducer,

the amplitude of an
echo is represented
by the degree of brightness

(i.e. echogenicity)
of a dot on the display.

Each tissue displays a different echogenicity,
allowing identification of structures.

86
Q

Anechoic:

A

Anechoic

veins/arteries offer no reflection and appear black.

87
Q

Hypoechoic

A

Hypoechoic:

muscle and central nerve plexus
offer weak reflections
and appear dark.

88
Q

Hyperechoic

A

Hyperechoic:
bone and peripheral nerves
offer strong reflections and
appear bright.

89
Q

Factors determining needle visualisation under ultrasound

improves
technique
size of needle
angle of insertion
depth
echogenicity
A

Technique deteriorates improves

Technique Out of plane In plane
Size of needle Smaller (22 G) Larger (17-G Tuohy)
Angle of insertion Steep Shallow
Depth of insertion Deep Shallow
Echogenicity Non-echogenic Echogenic (cornerstone reflectors)

90
Q

Cornerstone reflectors

how

A

introduced by some companies
(Pajunk),

these are intended to improve
needle visibility under ultrasound,

even at steep angles.

They do so by reflecting all ultrasound
waves without
losses.

91
Q

real-time spatial compound imaging

A

In real-time spatial compound imaging,

a transducer array is used
to rapidly acquire several

overlapping scans of an object
from different angles.

These scans are averaged to
form a compound image that
shows improved image quality
because of reduction of artefacts.

92
Q

technologies involve either one of the following:

A

Needle-guidance systems:
Sonic GPS (Ultrasonics) and eTrAX needle
systems (CiVCO).

Newer imaging modalities: Multibeam (Sonosite), Cross XBeam (GE)
and Flexi Focus (BK Medical).

93
Q

How does U/S Aid RA

Can detect what
demonstrate

reduces risk of

A

Ultrasound provides
real-time visualisation of the nerve
and
surrounding structures during regional anaesthesia.

It allows detection of anatomical variations
and
demonstrates spread of local anaesthetic
during injection.

Intraneural or intravascular
injection can be detected by ultrasound.

94
Q

How does it improve block

What does the evidence not demonstrate

A
Evidence shows ultrasound-guided peripheral nerve blocks can be 
more successful than 
peripheral nerve stimulator 
techniques and have
a faster onset time.

However, evidence to clearly demonstrate that ultrasound-guided
regional anaesthesia is safer (in terms of neural injury) than using a
peripheral nerve stimulator is still not available.

95
Q

In the short-axis view

A

In the short-axis view

tubular structures such as
nerves and blood vessels

appear as though they have been
sliced across their diameter,
like discs of salami.

96
Q

In the long-axis view,

A

In the long-axis view, tubular structures are sliced longitudinally
along the length of the tube.

97
Q

The needle approach is described

In plane

A

The needle approach is described as

in-plane if the needle remains parallel to
the ultrasound beam,
allowing visualisation of the tip and shaft.

98
Q

The needle approach is described

Out plane

A

In the out-of-plane approach,
the needle is inserted more
perpendicular to the ultrasound beam

and can only be visualised as a
dot when the needle crosses the beam.

99
Q

newer applications of electrical nerve stimulation include the following.

A

Percutaneous electrode guidance:
Sequential electrical nerve stimulation (SENS):
Epidural stimulation (Tsui test)

100
Q

Percutaneous electrode guidance

A

involves percutaneous stimulation
of peripheral nerves to identify a nerve
before skin puncture. This
reduces the number of unsuccessful painful insertion and helps identify
the best insertion point.

101
Q

Sequential electrical nerve stimulation (SENS):

A

delivers current at
3 Hz with sequential pulses
of 0.1, 0.3 and 1 msecond to improve
motor response.

102
Q

Epidural stimulation (Tsui test)

A

Epidural stimulation (Tsui test):
the placement of wired epidural catheters threaded into epidural space can be confirmed by electrical
stimulation between 1 and 10 mA. The motor responses elicited
direct toward the level of the tip of the catheter. Stimulation at
currents < 1 mA indicate intrathecal placement.

103
Q

Non-electrical methods to confirm the placement of epidural

catheters

A

Non-electrical methods to confirm the placement of epidural
catheters include
epidural pressure waveform guidance and
electrocardiographic guidance

104
Q

Multistimulation technique

A

Multistimulation technique involves seeking specific component bundle
motor responses separately and then blocking the component nerves
individually. For example, for the axillary block, the radial, ulnar, median
and musculocutaneous responses are sought individually

105
Q

Multistimulation technique

Advantages

A
Higher success rate
Lower total volume of local anaesthetic
needed
Shortening of onset times of nerve blocks
Lower potential of local-anaesthetic
toxicity because of lower doses
106
Q

Multistimulation technique

Disadvantages

A

Increased patient discomfort because of multiple needle
redirections
Time for the entire procedure is increased
Theoretically, the risk of nerve damage may be higher
because of repeated needle passage

the incidence of nerve injury with multistimulation technique has been
found to be similar to that of conventional techniques.

107
Q

Multistimulation technique useful for

A

Multistimulation technique has been found to be useful for

interscalene, axillary,
infraclavicular, mid-humeral, femoral and sciatic
nerve blocks.

108
Q

Multistimulation too risky for

A

However, frequent redirections in the supraclavicular area may
increase the risk of arterial puncture and pneumothorax, and are not
advised.

109
Q

As the current needed to stimulate nerve

calculation

what current is best used initially

Then what improves specificity

A

As the current needed to stimulate a nerve

is inversely proportional
to the square of the
distance from the needle,

high currents help in
finding the nerve initially.

Hence they increase the
likelihood of finding the nerve.

Subsequently, lowering the current
as the needle approaches the nerve
helps to improve the specificity of the response.

110
Q

The resistance encountered by a
stimulating electrode depends

directly on
inversely on

A

The resistance encountered by a
stimulating electrode depends

directly on the tissue resistance
and
inversely on the conductive
area of the electrode.

111
Q

How can nerve stimulation electrode be improved

A

Stimulating a nerve using a microtip electrode (i.e. despite high resistance) improves the specificity of the stimulation.

112
Q

What is water lipid ratio of nerves

How does this affect stimulation

A

Water–lipid ratio of tissues

is proportional to conductance,

and
since nerves have a high water–lipid ratio,

they have higher conductance than
skin, muscle, fat or bone;

hence they are stimulated
in preference upon application of a current.