3. Antiprotozoal and antihelminthic drugs.

Question 1

Which are the groups of antiprotozoal drugs?

Answer 1

• Malaria
• Amebiasis
• Giardiasis
• Trichomoniasis
• Toxoplasmosis
• Pneumocystis
• Leishmaniasis
• Trypanosomiasis

Question 2

Which are the antimalarials?

Answer 2

• Chloroquine
• Quinine, quinidine
• Mefloquine
• Primaquine
• Halofantrine
• Lumefantrine
• Sulfadoxine, pyrimethamine
• Atovaquone
• Proguanil
• Artemisinin

Question 3

Which are the drugs for amebiasis?

Answer 3

• Idoquinol
• Diloxanid furoat
• Metronidazole, tinidazole
• Paromomycin

Question 4

Which are the drugs for giardiasis?

Answer 4

• 1st line:
  
  • Metronidazole, tinidazole
  • Nitazoxanid
• 2nd line:
  
  • Paromomycin
  • Nitrofuran
  • Quinacrine

Question 5

Which are the drugs for trichomoniasis?

Answer 5

• Metronidazole
• Tinidazole

Question 6

Which are the drugs for toxoplasmosis?

Answer 6

• 1st choice:​
  
  • Spiramycin (in pregnancy)
  • Sulfamethoxazole +Trimethoprim
  • Pyrimethamine + Clindamycin + folinic acid
• Alternatives​:​
  
  • Pyrimethamine + Sulfadiazine + folinic acid

Question 7

Which are the drugs for pneumocystis?

Answer 7

• 1^st choice:
  
  • Sulfamethoxazole + Trimethoprim
• Alternative compounds:
  
  • Pentamidine or clindamycin + Primaquine or Atovaquone

Question 8

Which are the drugs for leishmaniasis?

Answer 8

Visceral leishmaniasis:

• Amphotericin B:
• Miltefosine
• Pentamidine

Cutaneous leishmaniasis:

• Pentamidine
• Ketoconazole

Mucocutaneous leishmaniasis - pentavalent antimonials:

• Sodium stibogluconate
• Meglumin antimoniat

Question 9

Which are the drugs for trypanosomiasis?

Answer 9

• African trypanosomiasis:
  
  • ​Eflornithine
  • Melarsoprol
  • Pentamidine
  • Suramine
• American trypanosomiasis:
  
  • ​Nifurtimox
  • Benznidazol

Question 10

Which are the drugs for helminths?

Answer 10

• Benzimidazoles:
  
  • Albendazole, mebendazole, tiabendazole
• Ivermectin
• Levamisol
• Pyrantel pamoat
• Praziquantel
• Niclosamide
• Bithionol