2nd Shift Glycosides: Common Sources Flashcards
5 Anthracene/Anthraquinone Glycosides
- Aloes
- Rhubarb
- Cascara sagrada
- Frangula
- Senna
Biological source of aloes
dried latex leaves of Aloe barbadensis (Curacao aloe)
Organoleptic properties of aloes
*color
*odor
*taste
*texture
*color - brownish black opaque mass
*odor - strong odor, resembles iodoform
*taste - bitter
*texture - waxy, somewhat resinous
Chemical constituents of aloes
aloe emodin (free state), aloin (glycoside), emodin oxanthrone, emodin anthrone, emodin anthranol, emodin, isobarbaloin and a resin, aloesin
free state constituent of aloes
aloe emodin
glycoside constituent of aloes
aloin
biological source and family of rhubarb
Rhubarb, rhizomes and roots of Rheum officinale; Polygonaceae
Preparation of rhubarb
rhizomes are collected from 6-10 year old plants and are cut in either longitudinal or transverse manner
Chemical constituents of rhubarb
*Anthraquinone with COOH: rhein, glucorhein
*Anthraquinone without COOH: emodin, aloe-emodin, chrysophanol, physcion
*Anthrone and dianthrone of emodin
*Heterodianthrones: Palmidin A, B and C
*Other constituents: rheinolic acid, pectin, starch, fat and calcium oxalate
biological source and family of cascara sagrada
dried bark of Rhamnus purshiana; Rhamnaceae
preparation of cascara sagrada
Bark collected during dry season
Organoleptic Description of Cascara sagrada:
* Color:
* Odor:
* Taste
* Size (Thickness):
* Shape:
* External Bark:
- Color: Outside-Purplish brown; Inside-Reddish brown
- Odor: Nauseatic odor
- Taste: Persistently bitter
- Size (Thickness): 1-4 mm
- Shape: Occurs in quills or channels. Also available in small, flat and broken segments
- External Bark: smooth with presence of scattered lenticel, lichens and cork
chemical constituent of cascara sagrada
*Normal O-glycosides (10-20%)
* Aloin like C-glycosides (80-90%) e.g. Barbaloin/Aloin, Deoxybarbaloin (Chrysaloin)
* Main active constituents: Cascarosides A, B, C and D
another name for Deoxybarbaloin
chrysaloin
biological source and family of frangula
dried bark of Rhamnus frangula; Rhamnaceae
preparation of frangula
Like cascara, bark collected during dry season