(2_3) Neurology in 1 week Flashcards
Neurology Overview Map
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Types of Dementia
Dementia (7)
1) Alzheimer’s disease
2) CJD
3) Frontotemporal dementia (Pick’s)
4) Huntington’s disease/Chorea
5) Lewy Body Dementia
6) Normal Pressure Hydrocephalus
7) Wernicke-Korsakoff syndrome
CCS: Dementia workup
Labs: BOUPI
CBC with diff
CMP
TFT: TSH/T4
B9 (Folic acid)/B12 (Cobalamin)
VDRL/RPR, HIV
Urine tox screen
Imaging:
CT/MRI brain
MMSE, neuro-psych testing
Donepezil, Olanzapine, Vit. E,
PSAF counseling
(ie Patient/Supportive care/Advance Directive/Family counseling)
CCS: Alcohol withdrawal management
1) thiamine then IV D5W NS
2) pyridoxine (B6)
3) folic acid
4) IV diazepam
5) follow K and Mg
6) naltrexone for maintenance therapy
7) addiction unit consult
8) social work consult
Thiamine IM, Lorazepam IV, Folic acid oral, multi-vitamin oral, Chlordiazepoxide oral, Haloperidol IV if agitated, replace phosphate, magnesium, Vit.K IV
Seizure and aspiration precaution, Thiamine, Dextrose, Lorazepam, Vit.K, Folic acid, replace Ph, Mg, and then Chlordiazepoxide, addiction unit consult, Rehabilitation, Anonymous
What are the late manifestations of Alzheimer’s?
Apathy and imprecise speech
What is the only abnormality seen on Alzheimer’s workup?
CT shows diffuse symmetrical atrophy
How do you treat Alzheimer’s?
Galantamine, rivastigmine, donepezil and memantine
What is the mechanism of action of memantine?
Blocks NMDA receptor
What are the main features of Pick’s disease?
Frontotemporal atrophy
Personality changes before dementia
Treatment same as Alzheimer’s
What is Lewy body dementia?
Parkinsonism plus dementia
What is CJD disease?
1) Prion is the cause
2) Rapid progressive dementia
3) Myoclonus
4) 14-3-3 protein in CSF
5) Abnormal EEG and no need for biopsy
What are the main features of normal pressure hydrocephalus?
WWW:
Wobbly /wide gait (ataxia)
wet ( urinary incontinence)
weird (dementia)
How do you diagnose normal pressure hydrocephalus?
CT and LP (normal pressure)
How do you treat normal pressure hydrocephalus?
Shunt
CCS: Headache
ESR
Temporal artery bx
Depression index