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Pharmacology for FRCR CO1 > 2.7 Drug interactions in cancer treatment > Flashcards

2.7 Drug interactions in cancer treatment Flashcards

1
Q

What do CYP450 inhbitors do to other drugs?

A

Drug clearance is slower and so drugs have greater effect

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2
Q

What is the mnemonic for CYP450 inhibitors?

A

STICKFACES
COMP

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3
Q

What are the inhbitors of CYP450?

A

Sodium valproate
Ticlodipine
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol (acute/binge), Amiodarone
Cipro, chloram
Erythromycin
Sulfonamides

Cranberry juice
Omeprazole
Metronidazole

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4
Q

What do CYP450 inducers do to other drugs?

A

Increase in CYP450 activity clears the drug faster and so the drugs have lesser effect

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5
Q

What is the mnemonic for CYP450 inducers?

A

BS CRAP GPS

Bullshit Crap GPS induces rage

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6
Q

What are the CYP450 inducers?

A

Barbituates
St John’s Wort

Carbamazepine
Rifampicin
Alcohol (chronic)
Phenytoin

Griseofulvin
Phenobarbital
Sulfonylureas

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Pharmacology for FRCR CO1 (7 decks)

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