262 - Intro to Heme Malignancies

Question 1

All ___ cells are CD3+

Answer 1

All T cells are CD3+

Question 2

What markers are present on all NK cells? (2)

Answer 2

CD16+, CD26+

Question 3

What kind of cell is this?

Answer 3

Monocyte

Differentiates into macrophages, dendritic cells

Question 4

What kind of cell is this?

Answer 4

Neutrophil

Multi-lobed; shoul have 4, more lobes is concerning

Question 5

What is the difference beween lymphoma and leukemia?

Answer 5

Lymphoma = tissue based, derived from lymphoid cells (B and T)

Leukemia = in bone marrow, can have myeloid or lymphoid origin

Question 6

All ____ cells are CD19+

Answer 6

All B cells are CD19+

Question 7

What is the major difference between myelodysplastic and myeloproliferative neoplasms?

Answer 7

It’s all in the name!

Myelodysplastic = dysplasia (will see decreased peripheral counts)

Myeloproliferative = elevated blood counts

Question 8

List 5 progeny of the common myeloid progenitor

Answer 8

• Neutrophils
• Eosinophils
• Basophils
• Mast cells
• Antigen-presenting cells

Question 9

The diagnosis of acute leukemia requires ___% blasts in the peripheral blood or bone marrow

Answer 9

The diagnosis of acute leukemia requires 20% blasts in the peripheral blood or bone marrow

Even if the peripheral blood looks fine, do a bone marrow biopsy - sometimes the blasts just hang out here, and it’s still leukemia

Question 10

What kind of cell is this?

Answer 10

Lymphocyte

I think T cells and B cells look about the same

Question 11

What kind of cell is this?

Answer 11

Basophil

Question 12

List 4 markers of immaturity in blood cells

Answer 12

• CD34
• CD117
• TdT
• CD1a

If any of these are present, probably a “blast”

Question 13

What kind of cell is this?

Answer 13

Eosinophil

Eosiniphilic (red) cytoplasm

Question 14

List 4 progeny of the common lymphoid progenitor

Answer 14

• NK cells
• T cells
• B cells
• Plasma cells