26: SLE - Craig

Question 1

SLE

Answer 1

• autoimmune disease
• diverse clinical manifestations
• characterized by production of autoantibodies to components of the cell nucleus

Question 2

why is lupus a high risk surgical pt

Answer 2

• accelerated atherosclerosis

Question 3

ANA testing

Answer 3

• low specificty
• 100% sensitivity
• ie if your ANA is neg, you don’t have SLE, if post maybe
• up to 30% population has pos ANA

Question 4

specific tests for SLE

Answer 4

• antidsDNA (specific - found in 30-60% SLE pts)

- antiSmith (specific - foundin 30% SLE pts)

Question 5

gold standard SLE tx

Answer 5

antimalarials (hydroxychloroquine)

Question 6

symmetric, painless, proximal muscle weakness

Answer 6

skeletal polymyositis

Question 7

limited v diffuse scleroderma **

Answer 7

which areas of skin are involved

diffuse

• anti Scl70
• interstitial lung disease
• renal crisis
• higher mortality

Limited

• anti centromere
• pulmonary htn
• no renal crisit
• lower mortality

Question 8

CREST

Answer 8

limited cutaneous system sclerosis

• calcinosis
• raynauds
• esophageal dysmotility
• sclerodactyly
• telangiectasias