2.5 Signal Transduction

Question 1

What makes the TGFß receptor unique (compared to what we’ve studied)?

Answer 1

no kinase involved

Question 2

TGFß acronym

Answer 2

Transforming Growth Factor Beta

Question 3

Function of TGFß

Answer 3

inhibits proliferation of human cells

Question 4

What do RI and RII phosphorylate?

Answer 4

serine and threonine

Question 5

What does mutant Smad4 often lead do?

Answer 5

pancreatic cancer

Question 6

TGFB process

Answer 6

Question 7

Process of Wnt: System in presence and absence of Wnt

Answer 7

Question 8

Wnt in the villi of the GI tract

Answer 8

activity of Wnt is greatest in the orange at the bottom and decreases as you go superiorly up the villi

Question 9

ß- catenin

Answer 9

a transcription factor; involved in the Wnt process

Question 10

APC acronym

Answer 10

Adenomatous polyposis coli

Question 11

GSK acronym

Answer 11

glycogen synthase kinase

Question 12

scaffolding protein

Answer 12

a protein that is used to holds components together, such as in the case of being able to easily phosphorylate one nearby

Question 13

Example of Two-Component Signaling Pathway

Answer 13

histidine kinase pathway

Question 14

histidine kinase mechanism

Answer 14

Question 15

phosphate transfer in histidine kinase: from amino acid to what amino acid

Answer 15

phosphate is transferred from hisitidine to aspartic acid

Question 16

example of environmental stimulus in histidine kinase

Answer 16

ethylene

Question 17

P15

Answer 17

gene encoding cell-cycle inhibitor

Question 18

PAI

Answer 18

gene for inhibitor of protease that degrades extracellular matrix proteins; plasminogen activator inhibitor