2.5 Phagocytic cells (Recognition + Response) Flashcards

1
Q

Pagocytes

A

-> Neutrophil, Eosinophil, Basophil, Monocyte, Macrophage

Function:

  • > General foreign specificity
  • > Acute inflammatory response
  • > Most prevalent leukocytes
  • > Short-lived (hours to days)
  • > Huge numbers
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2
Q

Phagocytosis - Mechanism

A

Neutrophils engulf + killthe microbes to which they bind

Bacterial fMet-Leu-Phe peptides activate Rac2 + bacterial are taken up into phagosomes

Phagosomes fuse with primary + secondary granules. Rac2 induces assembly of a functional NADPH oxidase in phagolysosome membrane -> generation of O2. Acidification as a result of ion influx releases granule proteases from granula matrix

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