25 NLE Flashcards
Easiest and least expensive assay to screen pregnant women for the risk of delivering a child with NLE
Anti-Ro ELISA or CIA
Mothers with lower titers of anti-Ro are at lower risk of delivering a child with cardiac NLE compared to those with higher titers
T
Sensitive but poorly specific in identifying pregnancies at risk for NLE
Anti-Ro60
Less sensitive but more specific for the development of CHB
Anti-Ro52
T/F Majority of mothers who deliver to children with NLE are asymptomatic or minimal symptoms of an autoimmune disease
T
T/F Women who deliver to a child with CHB tend to be more asymptomatic compared to those who deliver to a child with cutaneous manifestations
T
When an established autoimmune disease is present in the mother of NLE patient, ___ diseases are most commonly seen
SS, SLE, undifferentiated CTD
MC NLE manifestation
CHB
CHB MC develops when
18-24wks AOG
Fetal risk for developing CHB depends on (2)
Antibody titers and previous pregnancy outcomes
Inhibition of this calcium channel could at least in part account for appearance of autoimmune sinus bradycardia
L-type
Rate of recurrence of CHB is at least ___ that of a previously affected mother with high anti-Ro
4x
T/F Vast majority of fetuses born after delivery of an infant with CHB do not develop CHB
T, 80-85%
Risk factors most commonly associated with perinatal mortality in infants with NLE
1) Earlier gestational age at CHB diagnosis
2) Fetal hydrops
3) Myocarditis
4) EFE
5) CHB with HR <50
Rationale to treat a fetus with complete AV block
NOT to reestablish AV conduction
1) Mitigate more widespread cardiac inflammation
2) Augment fetal cardiac output
