24.2 Flashcards
- During paediatric gas induction, the gas flow recommended by SPANZA for least
environmental impact is
● 1L/min
● 2L/min
● 3L/min
● 4L/min
● 5L/min”
3L/min
The Society of Paediatric Anesthesia recommends 0.15/min/kg as the minimum safe and effective FGF during induction i.e . 3L/min for a 20kg child. Many anaesthetists routinely run 6-10L/min regardless of the child’s weight.
https://journalwatch.org.au/reviews/reducing-the-environmental-impact-of-mask
- The Mapleson circuit to best achieve normocarbia with mechanical ventilation is:
“● Mapleson A
● Mapleson B
● Mapleson C
● Mapleson D
● Mapleson E”
Mapleson D
Journal article entitled Mapleson’s Breathing Systems 2013: “For adults, Mapleson A is the circuit of choice for spontaneous respiration where as Mapleson D and its Bains modifications are best available circuits for controlled ventilation. For neonates and paediatric patients Mapleson E and F (Jackson Rees modification) are the best circuits.”
- SQUIRE guidelines
“From the SQUIRE website: SQUIRE stands for Standards for QUality Improvement Reporting Excellence. The SQUIRE guidelines provide a framework for reporting new knowledge about how to improve healthcare. They are intended for reports that describe system level work to improve the quality, safety, and value of healthcare.
PRISMA: Systematic review”
- Box and whisker plot - What does the box mean
Box = interquartile range
The five number summary is the:
minimum,
first quartile,
median,
third quartile and
maximum
- What does a green line on the rigid laryngoscope blade mean
(a) Reusable
(b) Recyclable
(c) Single use - disposable
(d) Immersible
? - single use?
Arndt blocker attachment point for the breathing circuit (just a schematic drawing provided in
the exam)
C
perpendicular port for ventilation, pop top for bronch, oblique port for suction
Vivasight components (arrow to the red bit in the exam)
Red port - flush port for the lens
Airway ports - blue = bronchial lumen, white = tracheal lumen
Monitor connector
Red port - flush for lens
Cuffs - tracheal clear, bronchial blue
What is the half life of semaglutide
3 days
7 days
14 days
7 days
https://pubmed.ncbi.nlm.nih.gov/29915923/
PREVENTT trial showed that in major abdominal surgery, iron infusions:
A Reduced allogenic red cell transfusion
B Reduced mortality
C Reduced readmission rates within 30 days
D Reduced infection rates
C - Reduced readmission rates within 30 days
Compared to UFH, enoxaparin
More selective for factor Xa compared to UFH which binds both Xa and thrombin via ATIII
- Child on 15mcg/kg steroids, duration of treatment to give hydrocortisone peri-operatively
A > 2 weeks
B 1 month
C 2 months
B - 1 month
AOA guidelines
DCD which is the organ which can have the longest ischaemic time
A Lungs
B Kidneys
C Liver
D Pancreas
E Heart
A - Lungs (90mins)
Warm ischaemia time:
Liver and pancreas 30mins
Heart 30mins (from sBP <90mmHg to cold perfusion)
Kidneys 60mins (from sBP <50mmHg)
Lungs 90mins (from sBP <50mmHg)
DCD criteria does not include:
A Immobility
B apnoea
C absent skin perfusion
D absence of circulation (no arterial pulsatility for 2 min)
C - absent skin perfusion
DCD. -absence of circulation 5 mins for withdrawal of cardio resp support
- if ECG present need to observe asystole for 5mins
Unresponsive, apnoea, no pulse/heart sounds
Post herpetic neuralgia, feels like insects crawling across head, what is it?
- Allodynia
- Dysaesthesia
- Formication
- Pruritis
Formication
- although technically dysaesthesia
Congenital long QT, drug should avoid:
A propofol
B thiopentone
C ketamine
Ketamine
Triggers:
- beta-agonists, ketamine
- SNS stimulation
- Other QT prolonging medications: antiemetics, antipsychotics, amiodarone, methadone
- bradycardia, tachycardia, hypertension, hypoxaemia, hypercapnia
- electrolyte disturbance. - low K, Mg, Ca
Treatment for recurrent torsades de pointes?
A - Flecainide
B- Lignocaine
C -Procainamide
D - Amiodarone
E - Sotalol
Lignocaine
TdP is polymorphic VT with long QT
First line treatment is Magnesium then treat the long QT
Amiodarone and procainamide will lengthen QT
https://www.emdocs.net/ecg-pointers-recurrent-and-refractory-torsades-de-pointes/
What level tryptase acceptable to diagnose anaphylaxis?
A- (1.2 of normal) + 2 /ml
B- (1.8 of normal) + 2
C- Normal + 2
D- 10/ml
E- 15/ml
A - 1.2 x normal + 2
UTD: The minimal elevation of the acute total tryptase level that is considered to be clinically significant was suggested to be ≥(2 + 1.2 x baseline tryptase levels) in units of ng/mL or mcg/liter
Treatment for refractory anaphylaxis?
A Glucagon IV 10 min
B Glucagon IV 5
C Glucagon IM 5 min
D Glucagon IM 10 min
Glucagon IV q 5mins (1-2mg)
other refractory treatment:
Norad infusion 3-40mcg/min
vasopressin bolus 1-2 units then 2U/hr
+/- metaraminol or phenylephrine
bronchospasm
salbutamol MDI 12 puffs (1200mcg) - IV bolus 100-200mcg +/- infusion 5-25mcg/min
Mg 2g over 20mins
+/ volatiles or ketamine
- Fem-fem VA ECMO, where is BG best representative of coronary PaO2?
- right radial
- Either radial
- Left radial
- Pre oxygenator
- Post oxygenator
Right radial
https://pmc.ncbi.nlm.nih.gov/articles/PMC8292640/
- Post op cognitive decline has an onset within:
- immediate post
- Within one day, lasting one week
- From ?3wk
- ?10 days post op for a year
- From 1 month to 1 year
From 7 days post op til 1 year post
Blue Book article 2019
Pre-eclamspia at 30 weeks with IUGR
A- low CO, low SVR
B- Low CO, high svr
C- High CO, low svr
D- High CO, high svr
B - Low CO, high SVR
https://www.ahajournals.org/doi/epub/10.1161/HYPERTENSIONAHA.118.11092
Women who subsequently developed preeclampsia/fetal growth restriction had lower preconception cardiac output (4.9 versus 5.8 L/min; P=0.002) and cardiac index (2.9 versus 3.3 L/min per meter2; P=0.031) while mean arterial pressure (87.1 versus 82.3 mm Hg; P=0.05) and total peripheral resistance (1396.4 versus 1156.1 dynes sec cm−5; P<0.001) were higher.
https://www.ajog.org/article/S0002-9378(20)31283-7/fulltext
Burns - expected physiological change in first 24 hours
A- High cardiac index
B- Increased PVR
C- Decreased SVR
D- High stroke volume
Increased PVR
- initially loss of intravascular volume + low CO and catecholamine surge -> vasoconstriction
https://journals.sagepub.com/doi/10.1177/0310057X20914908?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
Which increases the risk of blood product related graft vs host disease
- genetic variability between donor and recipient
- irradiated
- leukodepleted
- Immunodeficiency
- transfusion of non-cellular product
Immunodeficiency
The three primary risk factors for developing TA-GVHD are:
https://www.lifeblood.com.au/health-professionals/clinical-practice/adverse-events/TA-GVHD
Factors increasing risk:
- degree of immunodeficiency of the recipient.
- number of viable T lymphocytes transfused (affected by the age of the blood transfused, degree of leucodepletion and irradiation status), and
- genetic diversity between donor and recipient. Greatest risks are donations from blood relatives and with HLA-matched blood products (because in GVHD, the body cannot recognise the foreign T cells and allows them to engraft)
When reconstituted, fibrinogen concentrate should be transfused within:
- 30min
- 4h
- 6h
- 8h
6 hours
“RIASTAP product info:
If it is not administered immediately, it must be stored below 25oC and used within 6 hours of
reconstitution. The reconstituted solution should not be stored in the refrigerator”
- A man has this device put in because he isn’t suitable for anticoagulation with AF. What is a
WATCHMAN device/ where is it?
- left atrial appendage
- SVC
- IVC
- Right atrium
- Ascending aorta
LA appendage
A aortic mechanical On-X valve - has an inguinal hernia repair in 48 hours and his INR is 1.5, what should you do?
- bridge with enoxaparin
- bridge with heparin
- just withhold the warfarin
Withhold warfarin
On-X is approved for use with INR use 1.5-2.0
https://academic.oup.com/ejcts/article/65/5/ezae117/7646070
APRV ventilation
Spontaneously breathing patient
Longer inspiratory times (prolonged high pressure maximises recruitment) = better oxygenation
brief releases at lower pressure facilitate CO2 clearance
Similar to constant recruitment method
Best TOE view for detecting myocardial ischaemia
- Mid-Oesophageal 4 chamber
- Long axis
- 2 chamber
- Transgastric 2 chamber papillary
Transgastric mid papillary
“TOE was found to be good at detecting new left ventricular RWMAs, associated with ischaemia. In particular the transgastric short axis mid view of the left ventricle demonstrates areas of myocardium subtended by each of the three coronary arteries. It is therefore the most frequently used view for intraoperative monitoring of left ventricular ischaemia.” https://www.sciencedirect.com/science/article/pii/S0007091217351863#:~:text=In%20particular%20the%20transgastric%20short,monitoring%20of%20left%20ventricular%20ischaemia.
The pregnant MS lady, cat 1 section within 30min, what method
- spinal
- CSE
- Epidural
- GA
- Methylpred then GA
Spinal
Classic LMA cuff recommended pressure max (CmH2O)
30
40
50
60
60cmH2O intracuff pressure
Narrow complex tachycardia ECG in young person post op in PACU with SBP 90. What treatment
A. Modified valsalva
B. Adenosine
C. DCCV
valsalva
Child with status epilepticus, weight 20kg, which is NOT a recommended treatment with midazolam:
- IM 3mg
- intranasal 6mg
- intraosseous 3mg
- buccal 6mg
- IV 1.5mg
IV and IM doses too low
Buccal/ intranasal 0.3mg/kg x20 = 6mg
IV/ IO 0.15mg/kg x20= 3mg
IM 0.2mg/kg x20= 4mg
https://www.childrens.health.qld.gov.au/__data/assets/pdf_file/0021/174180/status-epilepticus-flowchart-and-medications.pdf
Highest rate of mortality is in BMI category of
- <18.5
- 18.5-24.9 - 25-29.9
- 30-34.9
- 35-39.9
BMI <18.5
Major burns patient, pharmacologic effects in relation to non-depolarising neuromuscular blockers
- Dose expected higher because of up-regulation of acetylcholine receptors