24 Stem Cells Flashcards

1
Q

blastocyst undergoes

A

gastrulation

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2
Q

gastrulatioin

A

form three germ layers

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3
Q

ectoderm

A

outer skin

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4
Q

mesoderm

A

inner skiin

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5
Q

endoderm

A

digestive tract lining

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6
Q

embryonic stem cells (ESCs)

A

can be extracted from inner cell mass of blastocyst and grown

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7
Q

pluripotent

A

be able to specialize to different cells

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8
Q

self renewal

A

create more stem cells

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9
Q

cellular potency

A

cell’s potential for differentiation

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10
Q

sequence for potency

A

totipotent
pluripotent
multipotent
unipotent

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11
Q

totipotent

A

fertilized egg

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12
Q

pluripotent

A

blastocyst

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13
Q

multipotent

A

ectoderm, mesoderm, endoderm

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14
Q

unipotent

A

differentiated cells

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15
Q

pluripotent differential regulation

A

transcription factors, cofactors, chromatin regulators

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16
Q

What happens when Oct4 is on

A

loose chromatin

17
Q

what happens when Oct 4 is off

A

condensed chromatin, differentiated cell

18
Q

iPSCs

A

reprogrammed somatic cells to pluripotent state

19
Q

stem cell niche

A

stem cells are in protected areas of an organ

20
Q

lineage tracing

A

tracing cells to determine descendants of stem cells

21
Q

organoids

A

researchers cna use stem cells to create complex organoids in vitro