239 - Diabetes Type 1 Flashcards
Which of the following symptoms suggests type 1 diabetes in a peadiatric patient?
Weight gain
Weight loss
Oliguria
Diarrhoea
Arthralgia
Weight loss
A patient with known type 1 diabetes is found unconscious. What is the most likely cause?
Diabetic ketoacidosis
Hyperglycaemia
Hypoglycaemia
Meningitis
Post-ictal state
Hypoglycaemia
- Which of the following results supports a diagnosis of type 1 diabetes in a young symptomatic patient?
Random glucose 14.5 mmol/l
Fasting glucose of 6.1 mmol/l
HbA1c 45mol/mmol
Glucose at 120mins 9.6mmol/l
Glycosuria +1
Random glucose 14.5
Q4. The retinal photograph demonstrates?
Pan retinal photocoagulation scarring B
ackground retinopathy
Proliferative retinopathy
Diabetic maculopathy
Retinal haemorrhage
Pan retinal photocoagulation scarring
Q5. A patient with type 1 diabetes attends clinic for annual review. What is the target HbA1c which is generally recommended?
•
a.Below 63 (8.0%) mmol/mol
b.Below 58 (7.5%) mmol/mol
c.Below 53 (7.0%) mmol/mol
d.Below 48 (6.5%) mmol/mol
e.Below 42 (6.0%) mmol/mol
•
•
c.Below 53 (7.0%) mmol/mol
Q6. The most commonly prescribed insulin regime for patients with type 1 diabetes in the UK is?
•
a. Twice daily pre mixed insulin
b. Basal bolus insulin
c. Insulin pump therapy
d. Sensor augmented pump therapy
e. Once daily insulin glargine
Basal Bolus
Q7. The retinal image shows feature of which
type of retinal pathology?
a. Background diabetic retinopathy
b. Diabetic maculopathy
c. Proliferative retinopathy
d. Pre proliferative retinopathy
e. Retinal haemorrhage
Background Diabetic retinopathy
(but because hard exudates in macula area actually maybe should be pre-proliferative)
Q8 Which of the following is an indication for insulin pump therapy?
•
•Recurrent hypoglycaemia
•Elevated HbA1c
•Injection phobia
•Non compliance with blood sugar testing
•HbA1c of 6.0%
Recurrent hypoglycaemia
Q9. This pattern of GFR is seen in which condition?
●
a. Acute kidney injury
b. Classical diabetic nephropathy
c. Diabetic glomerulosclerosis
d. Nephrotic syndrome
e. Reno vascular diabetic disease
Classical diabetic nephropathy
Q10. Which of the following symptoms suggests neuroglycopaenia in a patient with type 1 DM?
a. Chest pain
b. Confusion
c. Dry mouth
d. Sweating
e. Tremor
Confusion
Q12. Which of the following is an adrenergic response to hypoglycaemia?
•
a.Confusion
b.Limb weakness
c.Seizure
d.Slurred speech
e.Sweating
•
Sweating
The image shown represents
a. Background diabetic retinopathy
b. Pre proliferative retinopathy
c. Proliferative diabetic retinopathy
d. Diabetic maculopathy
e. Retinal haemorrhage
Proliferative diabetic retinopathy
Q14. Which of the following cutaneous manifestations is associated with type 1 DM?
- Abdominal striae
- Acanthosis nigricans
- Palmar erythema
- Tendon xanthomata
- Vitiligo
Vitiligo
Q15. Which of the following is most commonly seen in association with type 1 diabetes?
•
a. Acromegaly
b. Addison’s disease
c. Cushing’s syndrome
d. Psoriasis
e. Ulcerative colitis
Addison’s disease
Q.16 The earliest clinical manifestation of diabetic nephropathy is?
a. Dipstick positive proteinuria
b. Elevated Albumin : Creatinine Ratio
c. Elevated serum creatinine
d. Kimmelsteil Wilson lesions
e. Renal shrinkage on USS
b.Elevated Albumin : Creatinine Ratio
Q17. How often should patients with type 1 diabetes should have a retinal photograph to screen for diabetic retinopathy?
a. Annually
b. Every 5 years
c. At each clinic attendance
d. 6 monthly
e. Every 18 months
Annually
If changes - 3/6 monthly
Q18. In a patient with type 1 diabetes with hypertension what is the recommended first line class of anti hypertensive therapy?
a. ACE inhibitor
b. Beta blocker
c. Calcium channel blocker
d. Diuretic
e. Alpha blocker
ACE inhibitor
Q19. All patients with type 1 diabetes who are actively trying to become pregnant should be treated with which medication?
a. 400mcg of Folic acid
b. 5mg of Folic acid
c. 500mg Metformin
d. Clomiphene
e. 75mg Aspirin
5mg Folic acid
Q20. Which compound is measured when testing blood for ketone bodies?
a. Acetoacetate
b. Beta hydroxybuterate
c. Pyruvate
d. Lactate
e. Succinate
b.Beta hydroxybuterate
Q21. Which of the following biochemical results is consistent with a diagnosis of DKA
●
a. Blood glucose 10.0mmol/l
b.Base excess -2.0
c.Capillary ketones 4.5mmol/l
d.pH 7.31
e.Serum bicarbonate 21.0mmol/l
•
c.Capillary ketones 4.5mmol/l
Q22. A patient is diagnosed with DKA in the medical assessment unit. IV fluid resuscitation is commenced. What rate of IV insulin do you recommend initially?
a. 6 units/hr
b. 20 units/hr
c. 0.1u/kg/hr
d. 1.0u/kg/hr
e. 10% of total daily sub cutaneous dose
c.0.1u/kg/hr
Q23. Which of the following is a common trigger for DKA?
a. Acute infection
b. Dehydration
c. Long haul travel
d. Extreme physical exercise
e. Vomiting
Acute infection
Q24. You are called to a patient with type 1 diabetes who is confused and disorientated. His blood glucose is 2.0 mmol/l. He is able to swallow. Which treatment is most appropriate?
a. X4 Dextrose tablets
b. 50ml of 50% Dextrose IV
c. 1000ml 5% Dextrose
d. X2 Digestive biscuits
e. X2 Glucogel (hypostop) sachet
X2 Glucogel (hypostop) sachet
Q25. After treating an episode hypoglycaemia how long should you wait before checking the glucose response to therapy?
•
a. 5mins
b. 15mins
c. 30mins
d. 1 hour
e. Use clinical assessment
15 minutes
Q26 The structure of insulin is composed of how many polypeptide chains?
•
a.1
b.2
c.3
d.4
e.5
•
2
•Q27 When treating Diabetic ketoacidosis which electrolyte should to be monitored on a 2 hourly basis according to JBDS guidance?
a. Glucose
b. Sodium
c. Potassium
d. Magnesium
e. Bicarbonate
K+
Q28. In a patient with type 1 diabetes who is unable to eat due to nausea and vomiting. How would you manage his blood glucose control?
a.Omit all insulin
b.Omit rapid acting insulin
c.Intravenous insulin according to DKA protocol
d.Intravenous insulin and dextrose according to VRIII protocol
e.2 hours sub cutaneous boluses of insulin
●
d.Intravenous insulin and dextrose according to VRIII protocol
Q29. This patient has chronic deformity of the foot due to ?
a. Charcot neuroarthropathy
b. Diabetic neuropathy
c. Gout
d. Osteomyelitis
e. Peripheral vascular disease
a.Charcot neuroarthropathy
What causes type I diabetes?
Insulin deficiency following autoimmune destruction of pancreatic Beta cells
What auto antibodies can you look for in type I diabetes?
Anti-GAD antibodies
Islet cell antibodies
Z anti-a antibodies