238 Diseases Of Nose, Sinuses And Nasoparynx Flashcards

1
Q

What are the three vital functions of the nose?

A

1) concha nasal is centralis for thermoregulation and conditioning of air
2) conchae ethmoidaes for olfaction
3) pulmonary alveoli for gas exchange.

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2
Q

What are the 4 functional segments of the nose?

A

1) nasal entrance
2) respiratory chamber
3) olfactory chamber
4) nasal exit

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3
Q

What is the nasal vestibule?

What does it do?

A
  • voluminous bulb evolved from fusion o cranial termination of plica alaris(alar fold) with internal part of ala nasi (Nasi wing)
  • Primarily responsible for distributing the in-and expired air and has highest airway resistance of the upper airways

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4
Q

What does the nasolacrimal duct do?

A

= conducts lacrimal secretions from eye, -> not the vestibule by an orifice located rosto-medically into vestibular bulb.

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5
Q

What are the four air passages of the nasal cavity?

A

1) dorsal
2) middle
3) ventral
4) common nasal meats

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6
Q

What does the dorsal meatus do?

A
  • bypass for odorant-bearing inspired air around the complicated structure of the ventral concha during sniffing for olfaction
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7
Q

2 types of conchae dominate the nasal cavity what are they? What are their functions?

A

1) ventral concha (attached to maxilla)
- function = thermoregulation and air conditioning
- complex airway network

2) ethmoidal conchae ( attached to cribiform plate of ethmoid)
- function = olfaction
- less complicated airway network.

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8
Q

How is the nasal exit formed?

What epithelia line the nasal passage?

A
  • nasopharyngeal meatus, beginning with wing of vomer that crosses dorsal from medial to lateral and ends causally with choanae
  • The outlet is a tine tubby which in small dogs is 1-3mm
  • if both contralateral meatus are obstructed, the nasal respiration is impaired.
  • epithelia lining the nasal passages = olfactory, respiratory, squamous, and transitional
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9
Q

What does mucus do in the nasal cavity? What cells produce it? What is the mucociliary apparatus?

A

Functions:

  • homeostasis by providing defence against airborn irritants in nasal cavity and is essential for preventing foreign particles reach lungs.
  • mucus is a watery sticky material linimum most luminal surfaces of the Nasal mucosa. It is a defence mechanism that filters the inhaled air by trapping particles and certain pours
  • protein constitution contains bactericidal enzymes
  • produced by goblet cells and subepithelial glands.
  • mucociliary apparatus synchronises its beating of surface cilia to properly mucus at different speeds and indifferent directions. This helps drive the mucus along to the oropharynx where it is swallowed.
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10
Q

What epithelium lines the nasal chamber?

Vestibulum?

A
  • vestibulum is lined by squamous epithelium (similar to skin)
  • transitional epithelium covers transition into main nasal chamber
  • non-olfactory nasal epithelium is ciliated epithelium
  • ethmoidal conchae and caudal surface of septum are covered with olfactory epithelium.
  • olfactory mucosa is covered with non-motile sensory cilia, enabling dog to detect odorant concentrations at 10,000-100,000 times that of a human.
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11
Q

How does a dog thermoregulate?

A
  • inspired air flow through ventral nasal concha that has a large, rich vascularised surface of mucous membrane rolled into very fine space saving spiral lamella. The lateral nasal gland (glandular nasal is lateral is or Steno’s gland) located in maxillary recess provides moisture for evaporation.
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12
Q

What causes sneezing?

How does reverse sneezing occur? What does it achieve?

A
  • mucosal irritant or discharge
  • reverse sneezing = mechanosensitive aspiration reflex
  • head may be extended and elbows abducted.
  • Powerful contraction of inspiratory muscles and adduction of laryngeal cartilages generate negative pleural and tracheal pressure. The strong tracheal occlusion pressure with sudden opening of glottis while mouth is closed produces rapid inspiratory airflow though nose and nasopharyngeal. This tends to tear off irritant particles and accumulated mucus -> results in aspiration into oropharynx for swallowing.
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13
Q

Why is nasal discharge produced? What can cause nasal discharge?

A
  • usually mucopurulent nasal discharge has serious underlying cause
  • produced in nasal cavity as a reaction to mucosal inflammation and/or infection.
  • Discharge can drain from paranasal sinuses,
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14
Q

Why is airflow obstruction considered serious?

What are some reported signs in pets by owners?

A
  • Dogs complete inspiration through high anatomical nasal resistance (79% inspiratory, and 74% expiratory resistance)
  • partial or bilateral obstruction will result in considerable loss of body weight.
  • severe sleep problems result from permanent stenosis or intermittent collapse of airway.
  • owners will report pets sleep in sitting position, and are regularly interuppted by waking up or gasping for air.
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15
Q

List the specific physical examinations of the nose?

A
  • breathing sounds (strider)
  • Symmetry of face and muzzle
  • character of nasal discharge
  • facial deformity or ulceration
  • Patently of airflow through each nostril
  • condition of teeth and gums
  • examine roof of mouth of pharynx
  • ability to retro pulse eyes
  • pan on opening mouth or manipulating muzzle
  • epiphora
  • pigmentation/depigmentation of nose
  • size and texture of submandibular lymph nodes
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16
Q

What can cause stenosis and obstruction of nasal passageways?

A
  • hereditary malformations from excessive breeding can cause obstruction in nasal entrance, nasal cavity, and nasal exit
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17
Q

What can cause stenosis of nasal entrance? What is a challenge about treating it?

A
  • trauma (bite, car accident, gunshot injury)
  • chronic ulcerative inflammation(long-lasting sinonasal aspergillosis)
  • surgery at nasal entrance using excessive thermal energy
  • Surgery is challenging due to hi tendency for re-stenosing and temporal setting; a flp technique may be used to prevent this.
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18
Q

What causes stenosis of nasal cavity?

A

Intranasal obstruction is caused by any type of benign or malignant mass:
- tumours
- expanding granulation tissue induced by chronic inflammation
- intranasal cysts of varying origin.
- foreign bodies
- inspissated discharge
- deviated septum - high in small dog breeds and brachycephalic dogs. Also described in cats.
-

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19
Q

What are oronasal and oronasopharyngeal communication?

What causes congenital deformities?

A
  • Congenital or acquired communications between the oral cavity and the nose, respectively the oropharynx and the nasopharynx allows food and fluids to enter nasal pharyngeal passageways
  • Secondary bacterial infection is common and sometimes fungal growth can be observed
  • Congenital deformities are clefts of the lip and palate. The cause of clefting is unknown it is commonly agreed to be multifactorial with heriditary component.
  • Acquired oronasal communications result from trauma of cardiac accidents or due to high-rise trauma; stick injuries; dental problems, malocclusion, and deformity of the normal nasal architecture and lips occur in rostral defects.
  • long lasting processes such as chronic secondary bacterial inflammation cause expanding granulation tissue, and or inspissated discharge can obstruct nasal passageways.
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20
Q

What is the cause of bacterial rhinitis? What is the problem with its treatment

A
  • primary bacterial rhinitis is uncommon, and is usually secondary to the presence of foreign body or a consequence of gross an atomic changes from my optic disease, trauma, or irradiation.
  • ABs improve clinical signs temporarily, but when administered with sinonasal aspergillosis after initial improvement the AB’s can cause dreadful worsening of the aspergillosis infection.
21
Q

What causes LPR? What is the aetiology? How is it diagnosed?

A
  • idiopathic is an important cause of chronic nasal disease. Idiopathic LPR is one of the most common forms of chronic, non-infectious rhinitis in dogs and cats. It was diagnosed in 30% of the total population
  • undetermined aetiology but infectious, allergic, and immune mediated mechanisms have been suggested.

Dx: histopathologic identification of lymphoplasmacytic infiltrate in nasal mucosa and exclusion of other specific causes of chronic nasal disease.

22
Q

What are the presenting features of allergic rhinitis?

A
  • unusual or underdiagnosed
  • present with oculi nasal discharge, sneezing, nose rubbing, or head shaking and significant numbers of eosinophils in nasal exudate or nasal lavage.
23
Q

What are the common viral rhinitis causes in dogs and cats?

A

Feline herpesvirus (FHV-1) and feline calicivirus (FCV) remains significant clinical problem.

  • Signs = paroxysmal sneezing, conjunctivitis, and serous ocular and nasal discharge.
  • 5 days after sneezing, nasal discharge becomes mucopurulent and there may be ocular complications. Usually persist for 2- weeks
  • Viral rhinitis is prominent sign of canine distemper
  • Herpesvirus infection in newborn puppies is profuse mucopurulent nasal discharge
24
Q

What are the most common nasal tumours?
What clinical signs in dogs and cats are associated with nasal tumours include?
What treatment options are available for nasal tumours?

A
  • 3 most common tumours are adenocarcinoma,lymphoma, and undifferentiated carcinoma.
  • respiratory, ocular, and nervous system-related signs. Most common are attributed to upper airway obstruction with decreased airflow, spistaxis, and sneezing.
  • other signs include reverse sneezing, stertorous breathing, serous, MUO is or mucopurulent nasal discharge, dyspnea, lethargy, weight loss, facial deformity or swelling, and pain.
  • CNS signs = seizures and behavioural changes
    Treatment =
    -radiation therapy with or without aggressive cytoreduction can improve MST and is treatment of choice.
25
Q

What are the non-malignant masses that occur?

A
  • Benign tumours, inflammatory granulation tissue or other miscellaneous tissues
  • angioleiomyomas are benign tumoursthat originate from smooth muscle of vessels.
26
Q

How does the nasopharynx function during breathing and swallowing?

A
  • during swallowing the pharynx closes completely, but it must be open when nasal breathing.
  • dogs not breathe during lapping or mastication.
27
Q

What is the connection between the nasopharynx and the middle ear? What purpose does it serve.

A
  • The auditory tube (Eustachian tube) connects middle ear with the nasopharynx.
  • normal opening of. The Eustachian tube equalises atmospheric pressure in the middle ear; closing of ET protects middle ear from nasopharyngeal secretions.
  • mucociliary clearance drains mucus from middle ear into nasopharynx to prevent infection ascending into the middle ear.
  • The ET remains closed normally, and opens during yawning, sneezing, swallowing to equalise middle ear and atmospheric pressures. The tensor veil palatine muscle induces active dilation/opening during swallowing.
28
Q

What are some clinical manifestations of nasopharyngeal disease?

A
  • stertorous breathing
  • reverse sneezing
  • nasal discharge
  • expiratory cheek puff (complete obstruction of nasal pharyngeal airway)
  • retching (velopharyngeal incompetence)
  • vestibular signs (when with ET dysfunction)
29
Q

What three areas can the nasopharyngeal duct be obstructed?

A

1) most rostral point is underneath wing of veer
2) tubular canal itself
3) bilateral caudal opening of meatus (choanae)

30
Q

What implication does hereditary malformation have

A
  • in toy breeds chihuahua, Pomeranian, and shi Tzu the vomerine algae can be too large in relation to the lumen, leaving a passageway of 1mm or less.
31
Q

How can stenosis and obstruction of nasopharynx occur?

A
  • Congenital anomaly comparable to choanae atresia
  • Constrictive wound healing resulting from inflammatory condition, surgery, or trauma.
  • intraluminal reason such as inflammatory polyp or foreign body
  • extraluminal reason such as intrapalatal mass or subepithelial cyst
32
Q

What treatment options are available for nasopharyngeal stenosis? What should be kept in mind

A
  • surgical mucosal advancement & balloon dilatation have the problem of recurring stenosis.
  • removable silicone stent seems to be promising and prevent re-stenosis
  • function of auditory tube should be kept in mind. Any occlusion of nasopharyngeal openings of the ET leads immediately to secondary secretory otitis media.
33
Q

What is a nasopharyngeal tumour?

A
  • lymphoma is most common
34
Q

what is a nasopharyngeal inflammatory polyp?

A
  • nasopharyngeal inflammatory polyps are non-neoplastic masses developing from inflamed mucosa of middle ear or the auditory tube.
  • usually unknown cause
  • occur in younger cats
  • when grows from nasopharynx = stertor and then obstruction.
  • if grow from bulla tympanica-> eardrum-> external ear canal = otitis externa with otorrhea and head shaking
  • large polyps can be mass in external ear canal
35
Q

What causes nasopharyngeal cysts?

Are they serious?

A
  • cause of cysts is thought to be congential
  • acquired cyst can be retention of seromucinous glands
  • cysts of varying origin and location can obstruct cranial nasopharynx and obliterate the lumen
36
Q

What are the signs of foreign body?

A

-reverse sneezing, and seldom nasal discharge

37
Q

What are the 2 common diseases of the paranasal sinuses?

A

Sinonasal aspergillosis:
- is the infection of nasal and sinusoidal cavities with Aspergillus spp.

Cysts:

  • mucous retention cysts
  • need to be differentiated from malignant diseases
  • infrequently mucus retention cysts found in brachycephalic and miniature breed in sphenoid sinus
38
Q

What are the obstructing malformation in the upper airways as a consequence of selective breeding for brachycephaly?

A
  1. Nasal entrance:
    - stenosis of nares
    - stenosis of vestibulum
  2. Nasal cavity
    - obstruction of intranasal airways duue to malformed aberrantly growing turbinates together with intranasal mucosal contact points
  3. Nasal Exit - nasopharyngeal meatus and choanae
    - obstruction due to malformed conchae growing caudally
  4. Nasopharynx:
    - reduced lumen and increased collapsibility of nasopharynx due to
    - increased length of soft palate
    - increased thickness of soft palate
    - narrowing hamuli pterygoidei
    - space occupying structure in oropharynx
    - enlarged palatine tonsils
    - macroglossia
  5. Larynx
    - collapse due to laryngomalacia with impairment of arytenoid abduction (mostly pug)
    - obstruction of rima glottidis due to protruding tissue of lateral ventricle (larynngocele) (pug & bulldog)
    - obstruction of rima glottidis due to malformation over thick vocal folds
    - impairment of opening function (predominantly pug)
  6. Trachea
    - hypotrachea (bulldog)
    - tracheobronchomalacia (mostly pug)
39
Q

What are three factors causing stenosis to the nasal entrance?

A

1) the exterior part of nasal wing is too large and presses against philtrum/septum from lateral aspect
2) obstruction of nasal vestibulum due to large vestibulum bulb that is oversized for lumen inside vestibulum
3) immobility of the bulb.

40
Q

What causes intranasal stensosis?

what is the problem within the nasal conchae in brachycephalics?

A
  • small nasal cavity
  • conchae of brachycephalics are macroscopically and microscopically malformed and grow aberrantly into air conducting spaces, obstructing the lumen and causing increased intranasial resistance
  • intranasal mucosal contact points contribute to increased intranasal airway resistance
41
Q

What factors contribute to collapse/narrow nasopharynx (increased tissue in the box), and what this the treatment to open the area?

A
  1. Hypertrophic soft palate -> surgical reduction soft tissue mass
  2. Hypertrophic tonsils -> tonsillectomy
  3. Relative microglossia
  4. Obesity -> weight loss
42
Q

What facto cause stenosis -induced negative pressure and what is the intervention available?

A
  1. Stenosis nares -> Sx widen nares
  2. Stenosis vestibule -> vestibuloplasty
  3. Intranasal obstruction by relative conchae hypertrophy and aberrant conchae -> laser assisted turbine tome (LATE)
43
Q

What aspects of brachycephalics nasopharyngeal region contributes to BOAS?

A
  • Shortened skull
  • Overlong soft palate
  • Overthink soft palate
  • Obesity
  • Hypertrophic palatial tonsils and macroglossia
44
Q

What features of the larynx contribute to BOAS?

A
  • Everted ventricles (laryngocele ) = herniation of tissue alongside caudal border of ventricular is muscle
  • Thick vocal folds which contributes to narrowing of rima glottidis. They can also develop vocal fold granulomas
  • Loss of cartilage rigidity
45
Q

What features of trachea abnormalities are seen in bulldog breeds?

A

Tracheal hypoplasia = congenital abnormality in which ends of tracheal rings are opposed or overlap, resulting in narrow rigid, round lumen.

46
Q

What are the clinical manifestations of brachycephalic malformations?

A
  • nasal, pharyngeal, and laryngeal strider, expressed as dyspnea, loud snoring accompanied by gagging and coughing.
  • dyspnea can result in cyanosis, syncope, collapse, and death.

GIT: dysphasia, regurgitation, and vomiting

47
Q

What medical treatment is given to dogs with Brachycephalia?

A
  • short acting glucocorticoids (pred 0.5mg/kg PO q12h) and cage rest to reduce inflammation and oedema of pharynx and larynx and enhance airflow.
  • weight management
  • treat GIT disease
48
Q

What emergency drugs can be given to dogs to reduce respiratory distress in boas animals?

A
  • Acepromazine: dogs and cats 0.05mg/kg IV, SQ

- morphine: dogs 0.1 mg/kg IV q 3m to effect duration 1-4 hr