2.2, 2.3 Anxiety, management Flashcards

1
Q

What are the features of generalized anxiety disorder?

A

Excessive anxiety or worry about a number of activities or events for at least 6 months
-difficult to control the worry

Anxiety or worry associated with at least 3 of the following for the past 6 months:

  • restlessness
  • fatigue
  • difficulty concentrating
  • irritability
  • muscle tension
  • sleep disturbance
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2
Q

What are the features of panic attacks?

A

Discrete period of intense fear or discomfort that develop abruptly and peak in 10 minutes.

Physical symptoms prominent.
Mental symptoms:
-restlessness, irritability, mind blank, sleep disturbance, poor concentration, feeling out of control, fears of going mad

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3
Q

How is blood/injury/needle phobia different from other phobias?

A
The fear is associated with: 
-A FALL in BP
-BRADYcardia
-pallor 
(vasovagal/syncope like)
-sweating
-nausea
-tinnitus 

It is one of the phobias that could result in DEATH due to vasovagal collapse.

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4
Q

What are the two main treatment approaches to blood/needle/injury phobia?

A

Systematic desensitization

More recently, applied tension

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5
Q

Name 6 drugs and drug classes that are used to treat anxiety?

A
  • Barbiturates (not recommended)
  • benzodiazapines
  • antidepressant drugs
  • buspirone
  • pregabalin
  • beta-blockers (propranolol)
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6
Q

What are the pharmacological effects of benzodiazepines?

A
reduced anxiety and aggression 
hypnosis and sedation 
muscle relaxation
anticonvulsant affect
anterograde amnesia
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7
Q

Where in the body is glycine restricted to?

A

spinal cord and brain stem

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8
Q

What are the clinical uses of benzodiazapines?

A
acute tx of extreme anxiety
hypnosis
alcohol withdrawal
mania
delirium
rapid tranqualisation 
premedication before sx or during minor procedures
status epilepticus
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9
Q

What are the main problems with benzodiazapines?

A

paradoxical aggression
anterograde amnesia and impaired coordination
tolerance
dependence= rebound anxiety on withdrawal and physical symptoms

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10
Q

What are the symptoms and consequences of rapid withdrawal of benzodiazepines??

A

confusion
toxic psychosis
convulsions

insomnia, anxiety, loss of appetite, loss of body weight, tremor, perspiration, tinnitus, perceptual disturbances

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11
Q

What is the mechanism of neuroadaptation to GABA stimulation?

A

chronic treatment with GABA agonists results in decreased density og BZ receptors –> anxiety/convulsions

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12
Q

What is the protocol for withdrawing benzodiazepines?

A
  1. Transfer patient to equivalent daily dose of diazepam/chlordiazepoxide preferably taken at night
  2. Reduce dose every 2–3 weeks in steps of 2 or 2.5mg; if withdrawal symptoms occur, maintain this dose until symptoms improve
  3. Reduce dose further, if necessary in smaller steps; it is better to reduce too slowly rather than too quickly
  4. Stop completely; time needed for withdrawal can vary from about 4 weeks to a year or more
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13
Q

Which antidepressants are useful in the treatment of anxiety?

A
  1. SSRIs- panic disorder, OCD, PTSD, phobias, GAD (escitalopram, paroxetine)
  2. TCA- clomipramine, imipramine - 2nd line for panic disorder, OCD
  3. Venlafaxine- GAD
  4. Moclobemide- social anxiety disorder
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14
Q

How do monoamines (NA, 5HT) affect anxiety?

A

In stressful situations,

  • increased NA release from locus coeruleus neurons that project to frontal cortex and hippocampus
  • increased 5HT release from neurons that project to dorsal raphe nucleus

Benzodiazapines block these increases, thus blocking the monoamine effect, and the anxiety inducing effects.

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15
Q

What is the mechanism of action for SSRIs in their use in anxiety?

A

Initially, increased extracellular 5HT, anxiogenic properties!!
but chronically, mayt involve neuroadaptive changes and increased neurosteroid synthesis

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16
Q

What is the mechanism of action of buspirone and its use in anxiety?

A

Buspirone is a 5HT-1a agonist
weak anxiolytic in animals and slow onset in humans
may act preferentially on somato-dendritiv 5HT1a autoreceptors
-may be a partial agonist at post-synaptic 5HT1a receptors- this may explain no anxiogenic properties

17
Q

What is the best treatment for somatic symptoms of anxiety?

  • tremor
  • palpitations
A

beta blockers- propranolol