2154 ic13 (COPD)

Question 1

What is emphysema

Answer 1

Permanent enlargement of alveoli + disrupted alveolar attachments

Question 2

Genetic etiology of COPD

Answer 2

a1 antitrypsin deficiency

Question 3

Cause of chronic bronchitis

Answer 3

goblet cell hyperplasia, mucosal edema and mucus hypersecretion

Question 4

Cause of chronic bronchiolitis

Answer 4

Release of profibrotic mediators from airway epithelial cells stimulate fibroblast
Fibroblasts produce matrix proteins, resulting in peribronchiolar fibrosis