2.14 Pharm_ Intro to Blood clotting Flashcards
What are the 4 major events of hemostasis?
Hemostasis is composes of 4 major events that
occur in a set order:
Vasoconstriction
Platelet Actions: Adhesion, Activation,
Release or Secretion,
Aggregation
Fibrin Clot formation/coagulation
Fibrinolysis
Thrombus vs embolus?
Thrombus: Blood clot
Embolus: fragment of traveling clot
The major components of the hemostatic system are:
Vascular endothelium
Platelets
Coagulation system (Part 2: CPII)
Fibrinolytic system
Most clotting factors and anticoagulants are made where? and what do they commonly require
Liver. Require Vit. K
Name the following factors:
I
II
III
I: Fibrinogen
II: Prothrombin
III: Tissue factor
What is the difference between FII and FIIa
Factor II = Prothrombin (a zymogen)
Factor IIa = Activated Factor II = Thrombin
(enzyme)
What inhibits Aggretation by elevated levels of cGMP?
NO, Nitric oxide
Prostacyclin inhibits what when what is elevated?
Prostacyclin inhibits aggregation and activation of platelets when cAMP is activated
t-PA
Activates fibrinolysis. Activates Plasminogen to plasmin
Primary homeostasis?
Platelet Plug formation
What are the 3 mediators released by platelet activation that cause vasoconstriction?
serotonin (5-hydroxytryptamine; 5-HT) thromboxane A2 (TXA2) - a prostaglandin epinephrine
Response to injured vessel:
Exposure of blood to_______ that activates the intrinsic coagulation pathway.
Exposure of blood to ______FACTOR that activates the extrinsic coagulation pathway.
subendothelial COLLAGEN
subendothelial TISSUE
Secondary homeostasis
Formation of fibrin clot
Thrombin converts what to what?
Prothrombin is
converted to Thrombin;
Thrombin converts
Fibrinogen to Fibrin
Platelets come from what type of cell?
Megakaryocytes