21.2 Thyroid disease Flashcards
What is the thyroid gland?
An endocrine organ in the anterior midline of the neck, sat in front of the trachea and just below the thyroid cartilage.
2 lobes connected by an isthmus.
What cell types are found in the thyroid and what are their functions?
- Thyroid follicular cells: produce triiodothyronine (T3) and thyroxine (T4) which control the metabolic rate
- Parafollicular cells: secrete calcitonin which reduce calcium levels
Describe the development of the thyroid.
- Downgrowth of formane caecum (at the junction between the anterior two thirds and posterior third of tongue)
- Descends through the tongue, past the hyoid and to its midline position in the neck
- If a portion of the tract remains patent, a thyroglossal cyst can form
How is a thyroglossal cyst diagnosed?
It will appear as a midline swelling which moves on tongue protrusion and swallowing.
Confirmed via ultrasound or other imaging.
What is the difference between triiodothyronine and thyroxine?
- T3 is the active form
- T4 is the inactive form, converted to T3 in peripheral tissues
Levothyroxine is a manufactured form of T4 used to treat hypothyroidism.
What are the functions of T3 and T4?
Regulates metabolic rate: affects carbohydrate, protein and lipid metabolism
- Thyroxine also potentiates the actions of other hormones such as catecholamines and growth hormones
Describe the hypothalamic-pituitary-thyroid feedback system.
- Hypothalamus releases thyrotropin releasing hormone (TRH) to the anterior pituitary
- Anterior pituitary released thyroid stimulating hormone (TSH) to the thyroid gland
- Thyroid gland is stimulated to produce T3 or T4
What do you call a thyroid swelling that is visible?
A goitre
What % of thyroid swellings are benign?
95%
What does it mean when a thyroid nodule is described as “hot” or toxic”?
Means the thyroid is producing excess/additional thyroid hormones.
What symptoms may be associated with a thyroid lump?
- Dysphagia
- Odynophagia (pain on swelling)
- Stridor
- Hoarseness
- Can cause shortness of breath if pressing on trachea
Does a goitre always mean changes in thyroid hormones?
No, a goitre can occur with or without hormone changes.
What features are unique regarding the goitre present in Grave’s disease?
In Grave’s, the goitre has it’s own blood supply.
If a stethoscope is used you may hear excess blood supply- audible whooshing noise.
What is a diffuse thyroid enlargement indicative of?
- Grave’s
- Endemic goitre
- Hashimoto’s thyroiditis
What is a single thyroid node indicative of?
- Cyst
- Benign tumour (adeoma)
- Malignancy