211 - Osteoporosis Flashcards
What is bone remodeling?
constantly forms new bone while replacing older bone.
OsteoCLASTS
breakdown bone
OsteoBLASTS
Rebuilds bone
OsteoPENIA
bone loss
- Bone reabsorption accelerates, while bone formation decrease.
Bone demineralization
Occurs through loss of calcium and phosphorous salts leading to fragile bones and increase risk for fracture.
Primary Osteoporosis
-Postmenopausal women
- Men with Low Testosterone levels
Secondary Osteoporosis
prolong use of:
- steroids
-thyroid-reducing medications
-aluminum-containing antacids
- antiseizure medications
Most common areas of bone loss?
- Vertebrae in the lumbar spine
-hip - Distal radius ( near wrist)
At what age dose bone mineral density peaks?
between age of 25-30
Calcitonin
hormone that decrease osteoclastic activity.
Estrogen
inhabits bone formation
Parathyroid hormone
increases osteoclastic activity and bone turnover.
Why does postmenopausal osteoporosis occurs?
metabolic disorder or calcium deficit
risk factors for Osteoporosis
-Cigarrette smoking
- Early menopause
- Excessive use of alcohol
-Family history
- Female gender
- increasing age
- Decreased calcium intake
- sedentary lifestyle/immobility
- thin, small frame
- white or Asian race
clincical manifestations of Osteoprosis
- slient disease
- Dowager’s hump
- loss og height
- back pain
- Pain increase with activity and relieved by rest.
- Restriction of movement (thoracic and lumbar regions)
- fear of falling and/or history of previous falls
- previous fractures
- constipation
- abdominal distention
- reflux esophagitis