2.1 PreLec

Question 1

Blood is a complex fluid consisting of what?

Answer 1

Plasma - ECF rich in proteins

Formed elements - RBCs, WBCs, Platelets

Question 2

Study of the physio of blood?

Answer 2

Hematology

Question 3

Total Circulating Blood Volume in Males vs Females?

Answer 3

Males: 8% (8 mL/kg)
Females: 7%

Question 4

Plasma is 93% ___ and 7% ___? Plasma proteins?

Answer 4

93% Water
7% Dissolved solutes

Plasma Proteins:
Fibrinogen
Albumin (60%)
Globulins
Other regulatory Proteins

Question 5

Function of RBC

1. Transport of ___ through a ___ carrier —> tissues —> ____
2. Contain __enzyme__ —> CO2 transport
3. Acid-base buffer
4. ABO-Rh Blood Type

Answer 5

1. Transport of OXYGEN through a HEMOGLOBIN carrier —> Tissues —> Tissue Oxygenation
2. Contain carbonic anhydrase —> CO2 transport

Question 6

Average no. of RBC in males? Females?

Answer 6

Male: 5.2 M / uL (+/- 300K)
Female: 4.7 M / uL (+/- 300K)

Question 7

Term for
1. Normal RBC

2. 1 Changes in size
3. 2. Large size
4. 3 Small size
5. 1 Irregular shapes
6. 2 Burr cells, crenated
7. 3 Cell fragments
8. 1 Less color
9. 2 Round, more color
10. 3 Centrally stained
11. 1 Big nucleus
12. 2 Non nucleated

Answer 7

1. Normocytes
2. Anisocytosis, Macrocyte, Microcyte
3. Poikilocytosis, Echinocytes, Schistocytes
4. Hypochromic cells, Spherocytes, Target cells
5. Megaloblasts, Reticulocytes

Question 8

Where does hematopoiesis occur in embryo? Fetus? Adults?

Answer 8

Embryo: Yolk sac
Fetus: Liver (1’) and spleen
Adults: BM

Question 9

Responsible for the development of committed stem cells?
IL-3
IL-5
EPO
TPO
GM-CSF

Answer 9

IL-3: aka Multi-CSF; affects multiple lineages
IL5: Eosinophiles
EPO: RBCs
TPO: Megakaryocytes
GM-CSF: Can be for G-CSF or M-CSF

Question 10

HIF on Erythropoiesis

• Trigger:
• Aids in?
• Non-renal sensors stimulating erythropoiesis? (3)

Answer 10

• Trigger: Renal tissue hypoxia
• Aids in EPO synthesis
• Others: Prostaglandin, Epinephrine, Norepinephrine

Question 11

Vit B12 and Folic Acid deficiency will lead to? (Context: EPO)

Answer 11

Maturation failure, Megaloblastic Anemia

Question 12

What gives an erythrocyte its red pigment?

Answer 12

Hemoglobin

Question 13

Normal Hb values in Female? Male?

Answer 13

Male: 15 g/dL
Female: 14 g/dL