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Pharmacology 2 > 2.1 Pharm receptors > Flashcards

2.1 Pharm receptors Flashcards

1
Q

Neuronal excitability or ihibition depends on

A

the flux of ions through specific channls in neuronal membrans

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2
Q

excitation via membrane depolarisation

A

inc Na in or

dec K out

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3
Q

inhibition via membrane hyperpolarization

A

inc Cl in or

inc K out

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4
Q

2 major types of ion channels

A

voltage gated, NT gated

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5
Q

voltage gated channels are regulated by

A

membrane potentials

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6
Q

examples of voltage gated channels

A

na channels in axonal conduction, ca channels located presynaptically that play a critical role in the release of NT from synaptic vesicles

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7
Q

drugs that use voltage gated ion channels

A

anesthetics, anticonvulsants

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8
Q

neurotransmitter regulated gated ion channles regulated by

A

neurotransmitter interactions with specific receptros

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9
Q

NT gated channle examples

A

directly coupled ion channles, g protein couple ion channles

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10
Q

directly couple ion channles (NT gated)

A

Cl channel regulated by Gaba A rec –> NT include gaba, glutamate, glycine, Ach

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11
Q

drugs that use NT gated directly coupled ion channes

A

anesthetics, anticonvulsants, cholinergic drugs, setative-hypnotics

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12
Q

Gprotein ion channels (NT gated) use

A

cAMP, IP3, DAG, Ca as second messengers –> can open channles after binding and protein phosphorylation producing long term effects

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13
Q

Gprotein NT gated channels seein in

A

Ach, most amines (dopamine, NE, 5HT) and peptides (endorphins)

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14
Q

drugs that use NT gated Gprotein channesl

A

analgesics, antidepressants, antipsychotis, anxiolytics

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15
Q

CNS neurotransmiters

A

Amino acids, biogenic amines, others

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16
Q

CNS NT - AA

A

glutamate, gaba, glycine

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17
Q

CNS NT - Biogenic amines

A

NT, Dopamine, Serotonin

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18
Q

CNS NT - others

A

Ach, substance P, Enkephalin

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19
Q

Glutamic acid is

A

excitatory via influx of cations using direct copuling and gproting linked

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20
Q

Glutamic acid recptor example

A

NMDA receptor

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21
Q

target of NMDA receptor

A

Ketamine, Phencyclidine

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22
Q

Gaba is

A

inhibitory via inc Cl in flux and K efflux

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23
Q

Gaba activities increase by

A

anticonvusants, sedatives, hypnotics, muscle relaxants

24
Q

Gaba receptors

A

A and B

25
Q

Gaba A receptor

A

coupled to Cl ion channle, activation leads to Cl running into cells (hyperpolarization)

26
Q

Gaba B receptor

A

coupled to K ion channle, activation leacds to K efflux (hyperpolarization)

27
Q

Ach on M1

A

excitatory - dec K+ efflux via DAG

28
Q

Ach on M2

A

inhibitory - inc K efflux via cAMP

29
Q

Ach on N

A

excitatory - na influx via direct coupling

30
Q

baclofen binds

A

gaba B receptor

31
Q

Muscuranic blockers are used in

A

parkinsons

32
Q

AChE inhibitors are used in

A

Alzheimers

33
Q

Dopamine is mainly

A

inhibitory, 5 subtypes

34
Q

Dopamine activities increase by

A

CNS stimulants and anti-Parkinsons drugs

35
Q

Dopamine activites decrease by

A

antipsychotics

36
Q

NE is

A

excitatory or inhibitory, depending upon receptor subtypes (secon messenger coupling) - activities modifed by CNS stimulants, antidepressants, and some anxiolytics

37
Q

Serotonin (5HT) is

A

excitatory or inhibitory, depending upon receptor subtype - activites modified by CNS stimulants, antidepressants, and some anxiolytics

38
Q

Opioid peptides are

A

inhibitory - several subtypes, secon messenger coupling - activites modifed by opiod analgesics

39
Q

glutamic acid on excitatory recpetors are antagonized by

A

ketamine, phencyclidine, and newer antiepileptics

40
Q

gaba on ihibitory receptor GabaA drug agonsits

A

sedative -hypnotics and anti epileptic drugs

41
Q

gaba on inhibitory receptot GabaB drug agonists

A

baclofen

42
Q

Ach on M1 receptro(excitatory) antagonists

A

atropine (m blockers) block both M1 and M2

43
Q

Ach on M2 receptor (inhibitory)

A

atropine

44
Q

5HT3 causes vomiting so use

A

5HT3 blockers as antiemetics

45
Q

Ach N receptor is

A

excitatory

46
Q

Dopmapine receptor antagonis (mostly inhibitory receptors - some excitatory rec)

A

antipsychotics, antiparkonsonian drugs, amphetamines, cocain

47
Q

NE is amplified by

A

MAO inhibitors, TCA, amphetamines, cocaine

48
Q

Serotonin is amplified by

A

MAO inhibitors, SSRIs, TCA, some SNS stimulants and hallucinogens

49
Q

Opiod peptides are amplified by

A

opiod analgesics

50
Q

opiode peptieds are antagonized by

A

naloxone, naltrexone

51
Q

Ach is involved in

A

arousal, short term memory, learning

52
Q

NE is involved in

A

arousal, wakefulness, mood, cardiovascular regulation

53
Q

Serotoning is involved in

A

feeding behavior, control of body temp, regulation of mood, emotion and sleep –wakefulness cycles

54
Q

glycine is

A

an inhibitory NT that increases the entry of chlride into the post synaptic neurone, resulting in hperpolarization in the brain stem and spinal cord

55
Q

Strychinine action

A

inhibits the glycine receptors resulting in muscular contractions and tetany

56
Q

Substantce P mediates

A

the pain withing the spinal cord

57
Q

Enkephalin mediates

A

the analgesia and other CNS effects

Pharmacology 2 (12 decks)

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