2022 paper Flashcards
74 y/o patient on an assortment of medications for the past 10 years, presents with a #NOF low impact (think she kicks a football to her grandson and has a fracture) subtrochanteric femur #. Which drug is the most likely cause?
- Omeprazole
- Alendronic acid
- Bendroflumethiazide
- Atorvastatin
Alendronic Acid or omeprazole
This seems like a buzzwordy question and the mention of a low imapct and a subtrochanteric femur fracture which is atypical seems to be suggesting that the answer should be alendronic acid.
Bisphosphonates used for over 8 years is associated with atypical fractures….
HOWEVER Omeprazole use over one year is associated with fractures and according to the BNF, Omeprazole and fractures is uncommon, whereas alendronic acid and atypical fractures are rare or very rare.
so pick one of those 2, the buzzword style makes me lean towards alendronic acid.
Patient has hyperkeratosis suggesting Tinea pedis, what is the causative organism?
In between toes…
- Candida albicans
- Trichophyton rubreum
- Bacteria
- Bacteria
- Bacteria
Trichiphytum Rubreum
The Tinea Pedis is another name for athletes foot. The causative organism of tinea pedis is trichophytum rubreum.
SVC symptoms with lung mass in right upper lung. What is diagnostic investigation?
- CT chest
- Venography
- CT head
- Subclavian artery doppler
CT chest
Superior vena cava syndrome is the description of symptoms caused bu the obstruction of the superior vena cava.
This presents as
* oedema of the face
* Facial plethora
* distended veins
* Cough and or shortness of breath
The investigations are
* CXR
* CT Chest with contrast
* MRI
Venography may be considered
Prostate metastases to the spine, sclerotic, back pain, no nerve impingement, no fractures, PO morphine is not working.
- Tramadol
- Bisphosphonate
- IV zolendronate
- Radiotherapy
- Surgery
IV Zolendronate or bisohosphonate
This is a bisphosphonate. It is reccomended that for metastatic disease of the prostate, breast cancer or in multiple myeloma that is causing spinal metastatic bone pain, bisphosphonates should be used in the management of pain.
WITH PROSTATE CANCER ONLY AFTER OTHER TRADITIONAL METHODS HAVE BEEN ATTEMPTED… Hence the PO morphine in this case.
Overdose, dilated pupils with widened QRS. Patient refuses to disclose what medication was overdosed. What was the agent?
- Amitriptyline
- Diazepam
- Gabapentin
- Tramadol
- Codeine
Amitriptyline is a TCA. This leads to a dilation of pupils and can cause a prolonged QRS
Tramadol and codeine are both opiates and so will cause pinpoint pupils…
Diazapam is a benzo and an overdose in this would cause sedative symptoms. Drosimess, slurred speech etc.
History of atopy, with pollen being the trigger. Now spring and both eyes are watery, red and sore.
* Antihistamine eye drop
* Steroid eye drops
* Steroid orale
Anti-histamine eye drops if option for hypermellose I would go for that over this…
This is describing hay fever or allergic conjunctivivtis.
Allergic conjunctivitis is one of the causes of acute conjunctivitis… This presents with red eyes that is watery. If the symptoms are mild the management is artificial tears, with avoidance of trigger such as wearing glasses. For moderate disease the management is topical antihistamines that can be escalated to the use of topical steroids use.
Mild allergic conjunctivitis refers to itchy, watery, red eyes occurring seasonally and responding to supportive measures, including artificial tears and cool compresses.
Main DMARD for rheumatoid arthritis
- NSAID
- Methotrexate
- Hydroxychloroquine
- Azathioprine
Describe presentation of Rheumatoid arthritis
Methotrexate
Correct statin target 3 months after starting treatment:
- > 25% reduction in total cholesterol
- > 40% reduction in non-HDL cholesterol
- Total cholesterol <5.0
40% reduction in non-HDL cholesterol
Bilateral resting tremor, falls, shuffling (small stepping) gait, no bradykinesia, bilateral cogwheel rigidity, increase tone at the wrists. Taking chlorpromazine, statin and antihypertensive.
- Parkinson’s
- Drug induced
- Supranuclear palsy
- Essential tremor
Drug induced parkinsonism
These symptoms are parkinsonism but they are also bilateral and parkinsons is normally unilateral
Parkinson’s
* Bradykinesia => Short shuffling and smaller swing… Difficulty initiaing movements
* Tremor => improves with initiating a mvement aka better when doing something, PILL ROLLING
* Rigidity => cog wheel or lead pipe
* Mask like facies, flexed posture, drooling saliva sometimes depression or dementia is seen.
* Postural hypotension
Drug induced
* Antipsychotics and Metoclopramide are common causes of this.
* The onset will be faster + BILATERAL
* rigidity and rest tremor is uncommonin drug induced
Essential tremor
* postural tremor it is worse when the arm is stretched
* Improves with alcohol and at rest
* MANAGMEENT Propanolol
Supranuclear palsy
* There would be an upward gaze palsy
* Again the findings would be symmetrical
* Is associated with falls
123I‑FP‑CIT single photon emission computed tomography (SPECT). -> Investigation of choice if not sure between essential tremor and Parkinsons
A female patient woke up with leg weakness at 0700, daughter saw them last at 2300 and she was normal. Now 0800 she has progressive aphasia. 0830 CT scan shows infarct and no haemorrhage. She has a past history of AF.
* Give alteplase
* Give aspirin
* Give clopidogrel
* Give warfarin
Give Aspirin
The first treatment is Aspirin this is changed to a DOAC after 2 weeks.
the DOAC woould be started if the diagnosis of TIA is done.
A man who works as a painter and has lateral epicondylitis, what muscle group is responsible for his pain?
* Wrist flexors
* Wrist extensors
* Elbow flexors
* Elbow extensors
* Elbow pronator
Wrist extensor
Wrist extensor attach to the lateral epicondylitis.
The muscles from the medial epicondyle are the pronator muscles of the arm. this is likely group to be responsible of the pain.
Breastfeeding female patient with 2cm breast abscess for 48 hours. Normal observations. Patient was told to keep feeding as normal. Abscess was drained with needle and sent for MC&S. What to do now?
* Incision and drainage
* Flucloxacillin
* Amoxicillin
* Co-amoxiclav
* Encourage breastfeeding only
Give Flucloxacillin
< 5cm aspirate
> 5cm I and D
NEEDS Abx as well
Parkinson’s patient with recurrent pneumonia, on multiple medications for 10 years, which HCP to refer to
* Speech and language therapy
* Physiotherapy
* Occupational therapy
* Palliative care nurse
Speech and language therapy
Parkinsons can increase the risk of aspiration pneumonia so there is a need to reduce this with a potential of a speech and language therapist.
Pleural effusion with cancer – palliative female patient who had mesothelioma and was only going to live for a few more weeks.
* Aspiration
* Benzodiazepine (SC midazolam)
* IV morphine
* Furosemide
* Chest drain
Aspiration
. What management. Now using emollients
* Vit d analogue and topical potent steroids
* UV treatment
* Oral steroids
* Topical calcineurin inhibitor
* Mild topical steroids + antifungal
Vitamin D analogue + Topical potent steroids
Patient has Multiple sclerosis, is complaining of spasticity.
* Baclofen
* Carbamazepine
Baclofen
38 yo patient with bilateral conductive hearing loss, worsened during pregnancy. Especially at 2000 Hz
* Otosclerosis
* Presbycusis
* Neurofibromatosis type 1
* Meniere’s
Otosclerosis
This can get worse in pregnancy. It describes a conductive hearing loss, it happens with the stapes gets fixated on the oval window,
Menieres disease would have other symptoms of vertigo ear fullness tinnitus and sensoneural hearing loss
Patient comes to GP with vaginal discharge, fishy odour. She is going away on a wine tasting weekend tomorrow. What treatment?
* 7 days metronidazole
* Azithromycin
* Topical clindamycin
* Single dose Fluconazole
Topical Clindamycin
LADIES AND GENTLEMEN GIULIA IS A PSA GODD WITH IMMENSE KNOWLEDGE….
As you can see the first line in treating bacterial vaginosis is 7 days of metrondiazole, but the alcohol weekend means that the metrondiazole needs to be avoided. This means that it is likely that this patient needs the alternative which is topical clindamycin as a pessary.
Can be found if you check interactions with metrondiazole and alcohol….
NOTE: Stems of qs rarely give information for no reason…
Paracetamol overdose. Patient took it 18 hours ago, took 32 500mg tablets. 80kg male. What is your next step?
* IV N-acetylcysteine immediately
* Oral acetylcysteine
* Wait for paracetamol level to come back
* No action required
* Activated charcoal
IV N-acetylcysteine immediately
IV acetyltcystiene needs to be given if:
* the plasma paracetamol concentration is on or above a single treatment line joining points of 100 mg/L at 4 hours and 15 mg/L at 15 hours, regardless of risk factors of hepatotoxicity
* there is a staggered overdose or there is doubt over the time of paracetamol ingestion, regardless of the plasma paracetamol concentration; or
* patients who present 8-24 hours after ingestion of an acute overdose of more than 150 mg/kg of paracetamol even if the plasma-paracetamol concentration is not yet available
* patients who present > 24 hours if they are clearly jaundiced or have hepatic tenderness, their ALT is above the upper limit of normal
* acetylcysteine should be continued if the paracetamol concentration or ALT remains elevated whilst seeking specialist advice
Shoulder and hip stiffness and pain. Hard to get out of chair. Can’t remember if CK normal or high. (was normal)
* Polymyalgia rheumatica
* Polymyositis
* Fibromyalgia
Polymyalgia rheumatica
Creatinine kinase is raised in Polymyositis and fibromyalgia
Man returned from India with meningism. LP showed low opening pressure, normal glucose, high protein, lymphocyte predominant cells 90%.
* Bacterial
* Tuberculosis
* Viral
* Streptococcal
* Malaria
Tuberculosis
Patient with #NOF with pain uncontrolled pain. Was on IV paracetamol but it did not relieve pain. What is the next analgesia to offer?
* Repeated IV bolus morphine
* Diclofenac IM
* Femoral Nerve block
* Pethidine PCA
Repeated IV bolus morphine
After Paracetamol the next best management option is opioids.
NSAIDS are not reccomended
BETWEEN PETHADINE AND IV MORPHINE HONESTLY NOT SURE»> CHECK
Patient with typical SLE features, 3 year history of Raynauds, photosensitivity, positive ANA, clear chest and heart sounds normal, which investigation would you do next?
- Urine dipstick
- CXR
- Echocardiogram
- Spirometry
Urine dipstick
SOAPBRAIN MD
Seositis
Oral Ulcer
Arthritis
Photosensative
Blood disorder
Renal (Protien)
ANA +ve
Immunological (DsDNA, ANA etc)
Neurlogical (psych, seizure)
Malar Rash
Discoid rash
Ix
* ESR -> Disease activity
* dsDNA -> Changes with disease activity
* C3 and C4 decrease with activity
* ANA and ENA do not correlate with disease activity.
Managmeent
* Hydroxychloroquine
* Azathiopurine or mycophenolate mofetil
A 60 year old male with B symptoms with lymphadenopathy, anaemia raised neutrophils but no raised lymphocytes, raised LDH
- AML
- CLL
- Lymphoma
- Sarcoidosis
- Tuberculosis
Lymphoma
Delirium and usually well, patient wandering the wards at night and refuses to go to bed
- Lorazepam
- Haloperidol
- Orientation techniques
- Zopiclone
Orientation techniques
The above is an example of de escalation techniques which include verbal and non-verbal and this should be attempted before the use of Haloperidol or drug managmeent.
82 year old female had stroke, found to have AF, currently taking aspirin 75mg for previous MI.
- Change aspirin to apixaban
- Add clopidogrel
- Add warfarin
- Do nothing
Add warfarin
The aspirin needs to continue for lifelong with regards to the MI…
A DOAC or Vit K antagonist should be added so it has to be A or C
Change Aspirin to Apixaban
Warfarin is basically only used in patients with mechanical valve.
With PAtients with AF there is a need for the patient to be on a DOAC…
Stroke -> confirm ischaemic -> Aspirin wait 14days on aspirin still….
IF AF then DOAC (if chadsVASC score deems it necessary)
IF thrombotic then Clopidegrel
IF TIA and AF then DOAC straight away
A male and young patient in his 20s presents with sudden and painful vision loss however notes that this has happened before a few weeks ago and recovered after four weeks.
* Optic neuritis
* Anterior ischaemic optic neuropathy
Optic Neuritis
The other option is we think a permenant cause of loss of vision.
the case vignette we think is describing MS and that is associated with optic neuronitis.
Old man had a 3/7 hx of a fall, since then unable to weight bear. Physiotherapist unable to assess him due to patient being in pain when touched, but x-ray only showed minor degenerative changes only. What do you do?
* CT hip and pelvis
* Encourage him to weight bear
* Refer to old age psychiatry
* IV morphine
CT hip and Pelvis
The X-ray may miss out on the fracture and so because the findings are suggestive of a fracture we think that rescanning would be approapriate.
House fire inhaled. Patient needs increased ventilatory pressures, what is the reason?
- Abnormal alveolar capillary osmosis
- Surfactant insufficiency
- Accelerated pulmonary fibrosis
- Bronchospasm
Abnormal Alveolar Capillary osmosis
Essentially smoke inhalations makes patients dry because the water is lost into the lungs “oedema”. This then results in an abnormal gaseous exchange in the alveolar to the capillary blood.
A man who works as a painter and has lateral epicondylitis, what muscle group is responsible for his pain?
- Wrist flexors
- Wrist extensors
- Elbow flexors
- Elbow extensors
- Elbow pronator
Wrist Extensors
Breastfeeding female patient with 2cm breast abscess for 48 hours. Normal observations. Patient was told to keep feeding as normal. Abscess was drained with needle and sent for MC&S. What to do now?
- Incision and drainage
- Flucloxacillin
- Amoxicillin
- Co-amoxiclav
- Encourage breastfeeding only
Flucloxacillin
Breast Abscess < 5cm can be aspirated and drained.
This is then treated with Abx….
Breast Abscess > 5cm is treated with Incision and drainage.
Patients with MAstitis with no abscess get ecourged breastfeeding with abx being prescribed if the sysmptoms persist after this.
A 40 year old patient worried about getting cancer. Mum received a diagnosis of unilateral breast cancer at 67, brother has metastatic melanoma 5 years ago, uncle with lung cancer at XX age, grandparent with colorectal cancer at 82
- Send for BRCA1
- Reassure patient they do not have increased risk of breast cancer
- Sent to breast clinic
- Sent to mammography
Reassure patient they do not have an increased risk of breast cancer
The ages of these patients are all too old except the brother.
We dont think melanoma is associated with BRCA 1.
They may have been referred for testing if the patient had a 1st degree relative with breast or ovarian cancer and presented at a young age or the breast cancer was triple negative,
Parkinson’s patient with recurrent pneumonia, on multiple medications for 10 years, which HCP to refer to
- Speech and language therapy
- Physiotherapy
- Occupational therapy
- Palliative care nurse
Speech and language therapy
The recurrent infection we think is elluding to a poor swallow with aspiration pneumonia. as such we think that most likely this patient needs a SALT assessment as it is their role to be able to manage these patients.
T1DM patient and Graves, treated with carbimazole, now presenting with mouth ulcers
FBC
ANA
FBC
Not sure but we know carbimazole is associated with agranulocytosis, so we thought the question was probably trying to test whether we knew this… The ANA seems to be hinting at something like SLE whcich this person doesnt seem like she has.
Therefore we thought FBC would male sense.
A middle-aged man with headache, intermittent left-sided claudication, history of a TIA. He has 220/80 BP and has AKI. Biochemistry (presumably U&E) is normal. Ultrasound showing one kidney is 10cm and the other is 7cm. A scan also showed no obstruction in the ureters.
- MR urography
- Renin:aldosterone ratio
- MR angiography
- Urine catecholamines
- Renal biopsy
MR angiography
We think this patient has Renal artery stenosis. One of the findings of renal artery stenosis is a smaller kidney on one side. – for renal artery stenosis - decreased kidney size on side of ischaemia can be seen if chronic (asymmetrical kidneys)
In terms of investigation of RAS there is initial which would include renin:aldosterone ration and there is diagnostic which would be MR angiography -> patients with RAS would have a raised Renin to aldosterone ratio as opposed to Conn’s syndrome which would show the oppposite.
Additionally the intermittent left sided claudication and the history of TIA I think may also be hinting at Takayasu arterutis and that is associated with RAS