2022 Cardiovascular Disease 14% - lipid 2% Flashcards
Early diastolic opening snap? =
Midsystolic click? =
Snap - MS
Click - MVP
What are the valves that close during:
S1?
S2?
- S1: A/V valves (mitral and tricuspid)
- S2: ventricular valves (aortic and pulmonic)
Conditions a/w loud S1
MS, Short PR (WPW), Tachycardia, Thyrotoxicosis
Conditions a/w soft S1
MR, Long PR, inc’d LVEDP
Order of valves closing during physiologic S2 inspiration
A2 - AV closes first; P2 - PV closes last
Order of valve closure during physiologic S2 during expiration?
both valves (aortic and pulmonic) close at same time
When is the split between AV and PV increased during S2?
- AV closes earlier:
- PV closes later:
- AV closes earlier: MR, VSD
- PV closes later: PS, pulm HTN (loud P2) RBBB, PE
Condition a/w fixed split S2?
ASD
What is a paradoxical S2 split? What conditions are a/w paradoxical split S2?
- What: AV closes later
- Conditions: AS, HTN, LBBB
Conditions a/w S3
- Can be a normal finding in healthy kids and pregnant women
- Chronic MR
- CHF
- TR, PDA
Is generally a sign of increased filling pressures/flow and increased compliance
Conditions a/w S4
Decreased ventricular compliance
- LVH (e.g from longstanding HTN)
- Acute MR
- HOCM
- AS
- Condition a/w pericardial friction rub?
- Best heard when?
- wtd next?
- Rx with?
- Pericarditis (scratchy sound is SPECIFIC)
- Best heard when pt upright leaning forward
- TTE to r/o effusion
- NSAIDS + colchicine
Condition a/w sharp early diastolic sound (aka pericardial knock)
constrictive pericarditis
ASD has what effect on heart sounds?
Fixed split S2
HTN has what effect on heart sounds?
Loud A2
Pulm HTN has what effect on heart sounds?
Loud P2
Physiological split of S2: which valve closes first?
A2 before P2
Pulsus tardus
slowly rising/late pulse –> AS
- What is apical pulse?
- What is pulsus bisferiens?
- What conditions are a/w these
- apical: rapid rise
- bisferiens: single pulse with two peaks (midsystolic dip)
- a/w: think HOCM, may also be AR
Pulsus alternans:
- Definition
- Associated conditions
- Alternating (beat to beat) variability in pulse strength d/t decreased ventricular performance
- a/w severe CHF
Pulsus paradoxus
- what is it?
- conditions a/w pulsus paradoxus
- bp drop > 10mmHG during inspiration
- a/w: cardiac tamponade, SVC obstruction, pulmonary obstruction
Conditions a/w holosystolic (pansystolic) blowing murmur?
MR, TR, VSD (flow from ventricles to atria)
- Conditions a/w mid systolic crescendo decrescendo murmur?
- What happens when this condition is severe?
- a/w: AS, PS
- if AS is severe: crescendo becomes late peaking. In mild disease the murmur is early peaking
Condition a/w midsystolic click followed by murmur
MVP
Diastolic murmurs are heard during why type of cardiac blood flow?
Diastolic murmurs are heard when blood flows into ventricles. All diastolic murmurs are pathologic.
Mid diastolic murmur (may have opening snap)
MS, TS (-ASD)
Late diastolic sound or murmur; mid systolic plop
Arial myxoma; sx a/w fever, fatigue, wt loss; tx is surgical
Early, blowing, diastolic murmur
AR, PR
Continuous murmur
PDA
Pt with fixed split 2nd heart sound and mid-diastolic rumble: dx?
ASD
- Things that cause increased blood volume?
- Things that cause decreased blood volume?
- What happens to murmurs w/ increased blood volume?
- Sitting, squatting, leg raise; hand grip and phenylephrine inc afterload and therefore inc size and volume
- Standing, valsalva
- increased volume increases all murmurs except HOCM and MVP
What happens to murmurs w/ expiration? Why?
- All L sided murmurs increase except MVP and HOCM (these decrease)
- Increased flow to the L side of the heart
What happen to murmurs during inspiration? why?
- increase all R sided murmurs
- increase flow to R side of heart
What positions cause increased volume return to heart?
- Sitting, squatting, leg raising
- Handgrip and phenylephrine increase afterload and therefore increase volume
What positions cause decreased volume return to the heart?
Standing, Valsalva
Handgrip and phenylephrine have what effect on afterload?
Increases which murmurs?
- increases afterload,
- increases flow to murmurs that flow backward (AR, MR, VSD)
Handgrip or phenylephrine has what effect on MR, MVP, and HOCM?
- Handgrip and phenylephrine increases afterload
Decreases HOCM (less obstruction of LVOT)
Increases intensity of MR and MVP (MVP duration decreases)
- Amyl nitrate has what physiological effect?
- What happens to MVP, MR, HOCM, and AS with amyl nitrate use?
- Decreases afterload, so its easy for blood to be pushed into systemic circulation.
- Decreases MVP (intensity) and MR
- Increases HOCM (less LVOT obstruction) and AS
- Kussmaul’s sign: exam findings
- associated conditions?
- Paradoxical increased JVP on INSPIRATION
- seen with constrictive pericarditis, cardiac tamponade, RV infarct
- Physiological effect after PVCs
- Effect on HOCM, MVP, and AS?
- decreased afterload → rapid ventricular emptying
- increases HOCM, MVP, and AS
Inspiration has what effect on R sided murmurs?
R side murmurs increase
Which maneuver will distinguish HOCM vs AS?
Valsalva increases HOCM; decreases AS
16yo comes for routine checkup - PE reveals a murmur at LSB radiating thru precordium - no change with valsalva or respiration - ekg shows mild LVH. What is the diagnosis?
VSD; MC murmur at LLSB
Best way to decrease CAD risk between 1. controlling BP, 2. decreasing cholesterol, and 3. quitting smoking
quit smoking
RCA artery obstruction
- type of MI?
- EKG leads with STE?
- sx and rx
- inferior/posterior wall MI
- leads II, III aVF; V1, V2 (early R wave progression)
- sx: clear lungs, hypotension, elevated JVP, bradycardia; rx with fluids, atropine (if HR dec), avoid nitrates, plus other usual treatments (ASA, heparin, etc)
LAD artery obstruction
- type of MI
- EKG leads with STE
- sx and rx
- Type: Anterioseptal /apical
- Leads: V1-4
- sx: usual pain in chest, neck and arm, pulm edema, murmur (with MVP), S4 present. dx: ASA, heparin, nitrates, beta blocker, statin, PCI
Circumflex artery obstruction
- type of MI
- EKG leads with STE
- type: Apical/lateral MI
- Leads: lateral V5-6
Pt with hx chest pain; stress EKG reveals depression in lateral leads. Nuclear imaging reveals anteroseptal ischemia. Diagnosis?
High grade LAD stenosis
48yo F exertional chest pain, stress test done but stopped in 50 min from CP and ST depression in V4-6. Diagnosis?
High grade LAD stenosis
Patients likely to present with atypical or no chest pain with MI
Elderly, women, people with diabetes
Risk factors for atherosclerosis
- Modifiable: tobacco use, HLD, obesity, HTN, DM, psychocsocial stressors, EtOH, low physical activity, diet low in fruits/veggies
- Unmodifiable: Age, Male, Family hx premature CAD (LP (a))
ACS rx for NSTEMI or UA
- ASA, heparin, beta blocker, statin, nitrates, GIIB/IIIA inh (abciximab or tirofiban) if high risk UA
- angiography w/in 48h for NSTEMI and high risk UA
- NO tPA
ACS rx for STEMI
- ASA, heparin, beta blocker, statin, nitrates, morphine, clopidogrel (if no CABG planned)
- PCI in 90 min, or:
- tPA if w/in 12h of start of chest pain and PCI is more than 120 min away
Workup for suspected CAD - middle aged woman pw chest pain, chest discomfort or atypical CP - wtd?
- If can walk and baseline EKG normal: exercise EKG
- can walk and ST-T abnl or LVH: exercise echo
- if LBBB or V-pacing: vasodilator nuc stress test
Max predicted HR formula and goal HR during cardiac stress test?
- Max HR: 220-age
- Stress test goal: 85% of max
45yo F vague CP on exertion - baseline EKG normal - exc stress non-sp changes - wtd?
Exc stress with imaging If can walk - or non-sp ST chagnes with LBBB, LAHB, repolariz change then persantine/thallium study
Type of stress testing for a patient with LBBB or paced rhythm
Type of stress to AVOID in pt with active COPD or asthma
- LBBB or V paced needs: nuc stress test with vasodilator
- COPD/asthma: AVOID vasodilators (adenosine, regadenason, dipyrimidol) as these can cause bronchoconstriction
Pt with peripheral vascular dz scheduled for bypass surgery: has wheezing on exam - HTN controlled to 150/90 from 170/110. Type of cardiac workup?
Dob stress test (can’t use adenosine or dipyridamole with wheezing)
Who gets gated pool studies or MUGA scan
IN pt to determine LVEF and wall motion abnorm (dec’d LVEF poor prognostic factor on MUGA)
With what conditions should you NOT do stress test?
unstable angina, AS with sx
45yo DM2 with CP, EKG normal - stress test LEAST likely to be accurate is…
Exercise stress test
Obese woman with atypical CP undergoes exercise stress test - stops test after 5 min due to fatigue, no CP, HR inc’d by 50%, no EKG changes wtd?
This result is suboptimal and nonpredictive; instead schedule adenosine (vasodilator) stress EKG or echo
When is exercise stress test considered positive
- Flat or down sloping ST depressions>1mm & longer than 0.08
- If ST elevated = high grade stenosis
Pt with hx of chronic angina controlled on ASA and nitrates with increasing frequency of angina. WTD?
Add beta blocker; if pt is low dose BB dose, then up titrate to max tolerated dose
Pt with angina previously controlled on ASA, NTG and max tolerated beta blocker has new CP after walking 2 blocks. HR 55. wtd?
Coronary angiography; PCI if needed
Indications for cardiac cath/angiogram (4)
- STE or ST depression with + trop
- Poor prognostic factor on stress test
- Post infarct angina
- U/A on max dose meds with ongoing or new sx
Pt with UA on max ASA, nitrates, beta blocker. Hgb normal, no signs of infection or stress. Increasing episodes/frequency of angina. Angio show multivessel dz no amenable to PCI. wtd?
Ranolazine. decreases frequency of angina and improved exercise tolerance. No improvement in mortality.
Pt with angina controlled on BB, ASA, nitrates pw inc’d freq and and duration (lasting > 30 min) of anginal pain. EKG shows ST depression II, III, aVF. What is most likely mechanism for CP?
Atherosclerotic plaque with intermittent rupture and thromobolysis
65 y woman with exertional dyspnea and occasional chest pain. No relieving factors. EKG shows LBBB. wtd?
Stress test. Due to LBBB she needs adenosine PET (nuc test)
Pt on ASA, nitrates (with 12 hr nitrate free interval) and max BB with inc’d freq angina after walking 2 blocks; HR 55. WTD?
- Check CBC for anemia.
- Check for infxn
- if no signs of either of above get PCI d/t inc’d HR-> ischemia
Which one of these can get exercise EKG?
- pacemaker
- LBBB
- RBBB
RBBB is ok for exercise stress EKG
Antiplatelet medications: classes and examples
- ASA
- P2Y12 inhibitors (clopidigrel, ticagrelor, pasugrel)
- GB IIb/IIIa inhibitors (tirofiban, eptifibitide, abciximab)
Pt with CP, ST depression, biphasic T wave on anteroseptal leads present. Dx? Rx?
- Wellen’s syndrome: type A = biphasic T on anteroseptal precordial leads; type B = TWI on anteroseptal precordial leads
- Rx with trip to cath lab + LMWH + GP IIb/IIIa + Plavix + ASA
If angina or ST depression persists with or without troponin (+), wtd?
Cardiac cath
Pt stopped ASA 2 months ago 2/2 PUD - started on PPI now p/w CP, wtd?
start ASA
45yo M non-smoker, no DM p/w new onset CP more than 1/2 hr duration while shoveling snow - no EKG changes in ER, wtd?
Admit pt to chest pain unit. If cardiac enzymes neg, no ekg changes -> stress test
65yo M with severe retrosternal CP x 40min, sweating, diaphoresis - EKG shows ST dep, TWI. Patient is started on ASA, IV nitrates, BB, LMWH gpIIb/IIIa inhib - anginal pain resolves - 24 hrs later ST dep still persists. Dx? Rx?
- Dx: silent ischemia
- Rx: Cardiac Cath pt -> if angioplasty/PCI done - would decrease recurrent ischemia at 6 months (not reduce MI freq)
Multi-slice CT helpful to evaluate CP in what group of pts?
Exclude dx of CAD in LOW risk patients
Exertional dyspnea w/o chest pain may represent an anginal equivalent in absense of pulm dz in what type of patients? (4)
- DM
- Women (esp. post menopausal)
- Elderly
- Post CABG
- Pathogenesis of cardiogenic SOB?
- Diagnostic process if you suspect cardiogenic SOB?
- Path: ischemia-> inc’d LVEDP-> pulmonary edema
- Dx: empiric NTG or stress test or radionucleotide studies
65yo with MR murmur during exercise and disappears with rest, S4 present. Echo shows mild hyperkinesis and EF 60%. Etiology?
Ischemic
46yo M CP lasting 15 min - resolved in ED - HR/BP ok, No STE, only deep TWI V1-4. Dx? Rx?
Myocardial ischemia –> Wellens syndrome (LAD TWI synd) wtd? –> angiogram
Pt with CP episode at night that lasts 5-15min at rest. dx? wtd?
resting EKG neg/nonspecific ST changes → ambulatory EKG (to recreate CP) → positive → angiogram → neg → vasospastic angina
Pt pw CP, EKG neg - Thallium stress with reversible ischemia; cath neg, Dx? Rx?
- Dx: microvascular angina
- Rx: CCB, BB and nitrates
Elderly man with h/o syncope - he feels dizzy after dinner; EKG shows ST dep in II, III aVF - Repeat EKG after 15 min normal. Dx? Rx?
- Dx: Post prandial ischemia
- Rx: cardiac angio
Cause of STE? Causes Least likely to cause ST elevation is?
- Transmural MI
- LV aneursym
- post MI Acute pericarditis
- Prinzmetals angina
- Takotsubo
- least likely : unstable angina
Young man brought to ER with severe CP - EKG shows ST elev and MI dx.
- This is most likely a/w which drug?
- WTD next?
- General rx for CP on this drug
- General prevention of future episodes?
- Cocaine (a/w chest pain but is also thrombogenic)
- Next step: PCI
- Rx of cocaine with no EKG abnormalities: benzo, nitrates, ASA
- prevent with CCB
Cardiac enzymes onset, peak, duration
- Troponin: + 3-6hrs after MI, Peak 10-25hrs, Normal 5-15 days 2. CPK-MB: + 3-8hr, Peak 10-36hrs, Normal 3 days
- LDH: + 8 to 18hrs, Peaks 2-3 days, Returns to normal 6-10 days
- Myoglobin: - 0-85= normal inc’d immediately peaks in 1-4 hrs and normal in 24 hrs (best to assess new MI 1 day after old MI)
Pt with CP, STE and trop elevated → now s/p TPA with STE and CP resolved. Next blood draw trop more elevated. wtd?
Nothing - patients who are reperfused have faster peak and higher peak of trop than pt NOT perfused
Pt pw CP and STE; PCI is done. Next day Pt has new chest pain: best marker to diagnose new MI?
Myoglobin (peaks 1-4 hrs, normal 24 hrs)
65yo M with PNA to MICU on IV abx - EKG NSR but trop 1.3. wtd?
Echo
Low level trop seen in (and poor prognostic factor in) CHF, critial illness, LVH, HOCM, coronary vasopasm, PE, CKD
Pt pw chest pain and low BP - you suspect RV infarct - next dx step?
R sided EKG - V3R-V4R (on R chest) with STE very diagnostic for RV infarct.
Acute MI Q-wave vs non Q-wave MI
Q wave MI and non-Q wave MI both similar long term survival.
Always admit pt with new onset classic CP relieved by SL nitro even if pt young or EKG normal - thrombolytics NOT given for NSTEMI
Indications for thrombolysis
- Chest pain typical for infarction > 30 min with LBBB - STE 1mm in two continguous leads - < 12 hr post MI - < 2hrs away from PTCA center and NOT in shock
Contraindication for TPA
- Absolute - Prev hemorrhagic stroke - Other CVA events < 1 yr - IC neoplasm - Active internal bleed
- Relative - CVA > 1 yr - recent internal bleed or major trauma < 2-4 wks - BP>180/110 - Pregnancy - Active PUD
Indications for PTCA (PCI or angioplasty)
- Acute ST elev MI
- ST elevation with CP > 12hrs
- MI with shock and Pt is< 2hrs away from PCI center & < 75yr
- STEMI post CABG pts
- If tPA contraindicated
- Unstable angina
Ticagrelor, pasugrel, clopidigrel
- class of drugs
- can use if allergic to ASA?
- Use before/with PCI?
- Use before/with CABG
- Thienopyridine ADP Plt inhibitor (P2Y12)
- Pt with MI allergic to ASA -> ok to use
- Pt going for PTCA: use ticagrelor or pasugrel
- Pt going for CABG - NO P2Y12 inhibitors
When is CABG better than PCI?
- Left Main dz
- 3 vessel dz with dec’d LVEF
- Two vessel dz with prox LAD and decreased LVEF <35
- DM with CAD (tend to have diffuse lesions no amenable to PCI)
Pt with CAD s/p - what antiplatelet meds on d/c?
- MI no stent
- MI with stent
- no MI with stent
- ASA for life + P2Y12 (ticagrelor or pasugrel preferred) for at least 12 months
- ASA for life + P2Y12 (ticagrelor or pasugrel preferred) for at least 12 months
- ASA + P2Y12 (ticagrelor or pasugrel preferred) for at least 6 months
60 yo pt undergoes CABG - couple months later he is doing fine but has problems keeping accounts occasionally.
Dx: neurocognitive defect
Notes: post CABG neuro cog deficit: unsure etiology but may be related to microembolism of lipids or being on card-pulm bypass. Onset and duration 1-3 months after that old cases usu resolve and fewer new cases
Pt with retrosternal CP>1 hour, diaphoretic → EKG LBBB, STE in ant leads. Old EKG not availabe to compaire - CK and trop pending wtd?
Cath lab: CP with STE is enough to activate cath lab. Don’t wait for trop or LDH to come back.
Pt with chest pain, STE anterior leads → gets tPA with BP of 90/60. 2 hrs later STE in lateral leads BP drops to 80 pt SOB - no new murmurs - CXR pulm edema. wtd?
Angiography/PCI right away if pt with new sx and unstable after tPA. Otherwise wait for 2h post tPA to do PCI
Elderly pt with IWMI gets PCI to proximal RCA. Pt BP down to 90/60. wtd?
Bolus of IV fluids
Pt has PCI 6 hr ago. Now appears diaphoretic and has clammy skin. BP 80/60, hr 116. Exam shows no swelling or erythema at puncture site. IV fluid bolus given. Hgb 14 this AM. wtd?
CT abdomen
Pt with 14hrs CP, taken antacids without relief - EKG with STE in anterior leads - BP 140/80. Closest PCI center 1 hr away wtd?
- Give ASA, IV nitrates, IV BB and IV morphine
- Transfer & do PCI
60 yo p/w CP to small community hospital. Found to have AWMI- nearest tertiary center is more than 2 hours away. wtd?
tPA (if no contraindications) then transfer for PCI
Pt p/w MI; 3 days later has new CP relieved with NTG wtd?
Cath
Pt has cath - 2 days later pain in R groin - exam with erythematous and pulsatile mass wtd?
US r/o pseudoaneurysm
Pt with MI - 9 days later with persistent CP, worse on deep breath - pericardial friction rub, pt is on DAPT, ACEi and BB, and statin. CXR with effusion - EKG diffuse ST elevation with concatvity upwards and PR depression. Dx? Rx?
- Dx: Dressler’s syndrome - secondary pericarditis
- Rx: ASA high dose + colchicine
Factors shown to improve survival in MI (9)
- PCI
- thrombolytic therapy after Q wave MI
- BB
- ASA
- ACEi
- stop smoking
- statins
- ICD (40days later)
- cardiac rehab
Pt p/w CP - AWMI tx’d in CCU w/o complications, EF 30%. On D/C what meds?
- DAPT- ACEi, - statin - BB; ICD ( 40 days later - if high risk for VT then wear lifevest)
Pt had MI, stabilized - few months later. stress test abnormal - underwent cath - 70% stenosis LCx- started on ASA - what will incr long term survival?
start Statin (NOT CABG or PTCA)
Sequence of ACS medical and interventional management
ASA→SL NTG→BB→statin→UFH, P2Y12→PCI
Complications of MI (arrythmia)
< 48hrs: - VT (runs: observe. no incr mort. sustained=ischemic: stable –> IV lidocaine/amio. unstable: cardioversion) then back to cath lab. - NSVT - Blocks >48hrs: - VT (scar tisssue –> ICD maybe in 3months - NSVT
Complication of MI (mechanical ruptures)
- Papillary muscle rupture -> Acute MR - Septal rupture -> Acute VSD - Free wall rupture -> Tamponade
Ventucular arrythmias during acute MI
Ventricular ectopy or NSVT during AMI should NOT be treated VT/VFib occuring within 24 hrs of MI are independent risk factors for in house mortality BUT not risk for subsequent mortality from arrhthmia after d/c These DO NOT NEED long term antiarrhythmic therapy
Pt pw CP - EKG shows MI tx’d with tPA, heparin, nitrates, BB, ACEi - w/in 24 hrs pt has NSVT <30s wtd?
Observe
Mechanism of reperfusion arrhythmias?
Triggered activity; change in cardiac frequency due to accumulated Ca+
Pt with NSVT reverts to SR and is otherwise uneventful - 5 days later pt ready for d/c does pt require long hterm anti arrythmic?
No
Pt with VT or VF 48hrs afte rMI - no evidence of reinfarction wtd?
tx VTACH
Vtach/VF 48 hrs after MI or more - independent risk factor for mortality after d/c - after acute tx wtd?
ICD *
Pt has 2 discharges from ICD in 2 months wtd?
start amiodarone
Pt with ICD on amiodarone still getting shocks 4 months later wtd?
RF catheter ablation
Pt with MI refractive VT wtd?
adequate O2 and correct electrolytes Tx with amiodarone
Post MI surgery
elective surgeries at least 6 months post MI (risk of reinfarction highest first 3 months post MI)
Middle aged man clutches chest c/o severe CP - EKG diffuse STE with concavity up and PR depression wtd?
NSAIDs for pericarditis Best med for ppx - colchicine
If pt w/ pericarditis, has CXR showing cardiomegaly or has JVD or pulsus paradoxis. Best test to confirm dx?
echo r/o tamponade/effusion
Pt post CABG or AVR 4 yars ago with inc SOB for 3 months +JVD 9cm, hepatomegaly adn pedal edema, EKG and CXR normal - dx?
Pericarditis
MCC CHF
Ischemia>dilated CM>HTN, valvular dz, congential HDz *Always r/o ischemia in pt with new onset CHF and sudden decompensation in stable CHF MC precipitant of decompensation in CHF -> inc’d salt intake
CHF Systolic dysfxn
problem = dec’d contractility inc’d LVEDP dec’d LVEF Echo - dilated Tx: 1. ACEI, 2. BB - diuretics for sx: (Loop/ 3. spironolactone) - Digoxin - Hydralazine + nitrate** decr mort. if cant tolerate ACEI and in black pts. - ICD/CRT
CHF Diastolic dysfxn
dec’d relaxation inc’d LVEDP NORMAL EF Echo: hypertrophy, early restrictive filling, E/e’ > 15 Tx: - Candesartan (good elderly & setting of systolic as well) - ACEI - BB - CCB (long acting) - Diuretics
What BNP is specific for acute CHF?
<100: no chf > 500: definate CHF
Elevated BNP seen in…
LHF 2/2 diastolic dysfxn LHF 22/ systolic dysfxn RHF 2/2 COPD RHF 2/2 PE
60yo F eval for 3 month SOB on exertion, no CP, pmhx HTN DM2, HLD for which she takes meds.. wtd?
TTE check LV fxn/WM
Echo with inf wall hypokinesis and EF 40% best managment?
Cath (not dob stress echo)
50yo M pw inc’d SOB 3 days - pmhs HTN, BMI 40, JVP 14, b/l crackles and S3 heard, b/l pitting edema, BNP 160 - management?
IV lasix
BNP monitoring shows what?
Dec’d mortality in pt <75yo
Pt pw exc intolerance and DOE - exm JVD 10cm, few basal rales, S3+ - pt dx with CHF CE and trop normal - pt tx’d with diuretics and gts better - TTE shows EF 35% . what to proscribe at time of d/c
ACEI
In pt with new onset CHF - Cr up from 1.1 to 2 and potassium inc’d from 4 to 5.6 after starting ACEI.. wtd?
D/C ACEI, start hydralazine + nitrates
PT with CHF on lisinpril 5mg and lasix 40mg dialy pw continued fatigue, JVD 12cm, scatter rales, pitting edema , best management?
Maximize lisinopril - start IV lasix) (no diff between bolus vs infusion)
When to start BB in decompensated CHF
ONce volume overload corrected, start low dose BB and titrate up
When to f/u patient as outpt after d/c for acute decompensated CHF
F/u Appt in 1 week (not 2) decreased mortality wth early post dc monitoring
If CHF is taking lisinopril 10mg qd. what to add next?
carvedilol
Two months later pt on lasix 40mg, KCl supp, lisinopril 10 and coreg 25 bid NYHA III, EF 35% K is 5.2. waht do you start next?
D/C K supp and start low dose spironolactone
Pt on spironolactone at inc’d risk for what?
HyperK+ (potassium sparing diuretic)
Pt on spironolactone p/w L only breast enlargement 6 months later
Biospy (if unilateral)