2020 Flashcards
labs to order in drug induced SLE
- anti chromatin ab
- anti histone ab
- CBC and CRP
SCIG dosing for an average female adult
100 mg/kg/week = 5 grams a week in patient is 50 kg
What induces TH1
IL12, and IL27
What induces TH2
IL4
What is the master regulator of TH1 and TH2
Stat4 and stat6
what is the function of TH1 and TH2
- intracellular defence
2. allergies and anti parasitic
cytokines produced by Th1, th2
IFN-y
IL4, 5, 13, 21, 25, 10
Describe 3 mechanisms in which CDT cells kill infected or malignant cell
- secretion of cytokines or INF-g and TNFa which have anti tumor and anti viral microbial effects
- release of cytotoxic granules containing perforin, granzyme and leading to apoptosis of target cells
- fas-fas L interaction
- fas is on the surface of CD8 t cells binds fas on target cells and activates caspade cascade and apoptosis
egg protien
Gal d 1-5
fish protein
Gad d5
shrimp protein
Lit v1, Pen a 1
apple protein
mal d1, 2
CVID definition
- marked decrease of IgG with low IgM and IgA
- Decrease response to immunizations
- absence of other PID
- age > 4 years
dosing of acarizax
12 SQ HDM
dosing of grastek
2800 BAU
Oralair
300 IR
ragwitek
12 Amb AI U
MWS triad
- progressive sensorineural hearing loss
- secondary AA with nephropathy
- intermittent episodes of fever, headache, urticaria, and joint pain
labs in acquired angioedema
- low C4
- low C1q
- low of normal C1inh levels
3 reagents used in Penicillin testing
- Pre pen (penicilloyl-polylysine)
- Amoxicillin
- Pen G
- Penicilloate
- Penilloate
ciclesonide
omnaris
fluticase furoate
arnuity
fluticasone proprionate
flovent
aerius
desloratidine
elidel
pimecrolimus
cinquair
resilizumab
dymista
azelastine/ fluticasone proprionate
CI to penicillin skin testing
i. Overlying skin condition that might interfere with interpretation or overlying skin infection
ii. Inability to discontinue medications that might interfere with testing
iii. History of SCAR to penicillin
Approximately what percent of individuals with latex allergy have associated hypersensitivity to a related food?
30-50%
Describe how you would evaluate a patient with suspected allergic reaction to a local anesthetic.
- Skin test with undiluted LA (ideally mention using preparation without epinephrine)
- Intradermal with diluted LA (1:100 ideally mentioned, 1:10 could be accepted)
- If positive, evaluate other LAs for safe alternative
- If negative, mention challenge
Mention protocol (1-3 steps, with or without single-blind saline step, as long as reasonable)
significance of IFN-g/ IL4 ratio
it goes up in AIT
ACEi should be considered for discontinuation in which situation?
VIT
benefits of SLIT
- home administration
- increased stability and ensured standardization of dosing
- improved reliability in dosing and compliance
- FDA approved products
fatality rate of SCIT
1 in 2 million injections
Rfs for asthma mortality
- past history of sudden, severe exacerbations
- prior intubation and ICU management
- > 2 hospitalizations for asthma in past two years
- > 3 ED visits for asthma in past year
- poor perceivers of dyspnea
- low SES
filaggrin is part of which skin layer?
stratum corneum
which cytokine is important in pruritus and why?
IL-31 expresses IL4 and IL13
s. aureus super antigen rapidly induces IL31
chemokines increased in AD
- RANTES
- MCP-4
- eotaxin
Hanifin and Rajka Criteria
Major
- pruritus
- facial or extensor involvement in kids
- flexural lichenificantion in older children and adults
- chronic or relapsing dermatitis
- personal or family history of atopic disease
occular problems w AD
- atopic keratoconjunctivitis eyelid dermatitis due to increased # IgE bearing langerhans cells
- keratoconus - corneal deformity from eye rubbing
- anterior subscapular cataracts
Crisaborole
PDE4 inhibitor
Eucrisita
