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2020 Flashcards

1
Q

labs to order in drug induced SLE

A
  1. anti chromatin ab
  2. anti histone ab
  3. CBC and CRP
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2
Q

SCIG dosing for an average female adult

A

100 mg/kg/week = 5 grams a week in patient is 50 kg

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3
Q

What induces TH1

A

IL12, and IL27

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4
Q

What induces TH2

A

IL4

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5
Q

What is the master regulator of TH1 and TH2

A

Stat4 and stat6

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6
Q

what is the function of TH1 and TH2

A
  1. intracellular defence

2. allergies and anti parasitic

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7
Q

cytokines produced by Th1, th2

A

IFN-y

IL4, 5, 13, 21, 25, 10

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8
Q

Describe 3 mechanisms in which CDT cells kill infected or malignant cell

A
  1. secretion of cytokines or INF-g and TNFa which have anti tumor and anti viral microbial effects
  2. release of cytotoxic granules containing perforin, granzyme and leading to apoptosis of target cells
  3. fas-fas L interaction
    - fas is on the surface of CD8 t cells binds fas on target cells and activates caspade cascade and apoptosis
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9
Q

egg protien

A

Gal d 1-5

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10
Q

fish protein

A

Gad d5

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11
Q

shrimp protein

A

Lit v1, Pen a 1

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12
Q

apple protein

A

mal d1, 2

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13
Q

CVID definition

A
  1. marked decrease of IgG with low IgM and IgA
  2. Decrease response to immunizations
  3. absence of other PID
  4. age > 4 years
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14
Q

dosing of acarizax

A

12 SQ HDM

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15
Q

dosing of grastek

A

2800 BAU

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16
Q

Oralair

A

300 IR

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17
Q

ragwitek

A

12 Amb AI U

18
Q

MWS triad

A
  1. progressive sensorineural hearing loss
  2. secondary AA with nephropathy
  3. intermittent episodes of fever, headache, urticaria, and joint pain
19
Q

labs in acquired angioedema

A
  1. low C4
  2. low C1q
  3. low of normal C1inh levels
20
Q

3 reagents used in Penicillin testing

A
  1. Pre pen (penicilloyl-polylysine)
  2. Amoxicillin
  3. Pen G
  4. Penicilloate
  5. Penilloate
21
Q

ciclesonide

A

omnaris

22
Q

fluticase furoate

A

arnuity

23
Q

fluticasone proprionate

A

flovent

24
Q

aerius

A

desloratidine

25
Q

elidel

A

pimecrolimus

26
Q

cinquair

A

resilizumab

27
Q

dymista

A

azelastine/ fluticasone proprionate

28
Q

CI to penicillin skin testing

A

i. Overlying skin condition that might interfere with interpretation or overlying skin infection
ii. Inability to discontinue medications that might interfere with testing
iii. History of SCAR to penicillin

29
Q

Approximately what percent of individuals with latex allergy have associated hypersensitivity to a related food?

A

30-50%

30
Q

Describe how you would evaluate a patient with suspected allergic reaction to a local anesthetic.

A
  • Skin test with undiluted LA (ideally mention using preparation without epinephrine)
  • Intradermal with diluted LA (1:100 ideally mentioned, 1:10 could be accepted)
  • If positive, evaluate other LAs for safe alternative
  • If negative, mention challenge
    Mention protocol (1-3 steps, with or without single-blind saline step, as long as reasonable)
31
Q

significance of IFN-g/ IL4 ratio

A

it goes up in AIT

32
Q

ACEi should be considered for discontinuation in which situation?

A

VIT

33
Q

benefits of SLIT

A
  1. home administration
  2. increased stability and ensured standardization of dosing
  3. improved reliability in dosing and compliance
  4. FDA approved products
34
Q

fatality rate of SCIT

A

1 in 2 million injections

35
Q

Rfs for asthma mortality

A
  1. past history of sudden, severe exacerbations
  2. prior intubation and ICU management
  3. > 2 hospitalizations for asthma in past two years
  4. > 3 ED visits for asthma in past year
  5. poor perceivers of dyspnea
  6. low SES
36
Q

filaggrin is part of which skin layer?

A

stratum corneum

37
Q

which cytokine is important in pruritus and why?

A

IL-31 expresses IL4 and IL13

s. aureus super antigen rapidly induces IL31

38
Q

chemokines increased in AD

A
  1. RANTES
  2. MCP-4
  3. eotaxin
39
Q

Hanifin and Rajka Criteria

A

Major

  1. pruritus
  2. facial or extensor involvement in kids
  3. flexural lichenificantion in older children and adults
  4. chronic or relapsing dermatitis
  5. personal or family history of atopic disease
40
Q

occular problems w AD

A
  1. atopic keratoconjunctivitis eyelid dermatitis due to increased # IgE bearing langerhans cells
  2. keratoconus - corneal deformity from eye rubbing
  3. anterior subscapular cataracts
41
Q

Crisaborole

A

PDE4 inhibitor

Eucrisita

AI Flashcards (24 decks)

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