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Mock Exams (TL) > 2018 Mock Exam- Camp ACLAM > Flashcards

2018 Mock Exam- Camp ACLAM Flashcards

1
Q

An investigator is interested in studying animals with blood chimerism for the purpose of elucidating cellular or humoral circulating factors that contribute to ageing phenotypes. Which surgical procedure is appropriate for accomplishing this goal?

a) parabiosis
b) renal subcapsular xenograft
c) splenectomy
d) bone marrow transplantation

A

Parabiosis

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2
Q

Which of the following strains of mice is commonly used for experiments involving humanization (engraftment of human bone marrow, liver, and/or other cells)?

a) Crl:NU(NCr)-Foxn1nu
b) NOD.Cg-Prkd scid il2rg tmWjl/SzJ
c) B6SJL-Tg(SOD1*G93A)1Gur/J
d) AKR.B6.Hgb

A

b)NOD.Cg-Prkdc scid il2rg tmWjl /SzJ

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3
Q

What differentiates Watanabe heritable hyperlipidemic (WHHL) from St. Thomas Hospital mixed hyperlipidemic (SMHL) rabbit models?

a) SMHL rabbits are hypertriglyceridemic, whereas WHHL rabbits maintain normal to low triglyceride levels
b) WHHL rabbits are hypertriglyceridemic whereas SMHL rabbits maintain normal to low triglyceride levels
c) WHHL rabbits have marked deficiency in low-density lipoprotein receptors (LDLR), whereas SMHL rabbits maintain hyperlipidemia with normal LDLR function
d) SMHL rabbits have marked deficiency in low- density lipoprotein (LDLR), whereas WHHL rabbits maintain hyperlipidemia with normal LDLR function

A

c) WHHL rabbits have marked deficiency in low-density lipoprotein receptors (LDLR), whereas SMHL rabbits maintain hyperlipidemia with normal LDLR function.

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4
Q

Which of the following is FALSE when describing chlorine dioxide disinfectant?

a) After mixing chlorine dioxide gas into solution, it has a long shelf-life lasting for several months before degrading.
b) Compared to sodium hypochlorite, chlorine dioxide is effective over a broader pH spectrum.
c) Higher humidity enhances the antimicrobial effectiveness of chlorine dioxide
d) The antimicrobial efficacy of chlorine dioxide increases as the temperature increases

A

a) After mixing chlorine dioxide gas into solution, it has a long shelf-life lasting for several months before degrading.

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5
Q

Which of the following describes infection with murine fur mites?

a) Fur mites are easily transmitted by fomites and to dirty bedding sentinels
b) Myobia musculi eggs are laid on the middle of the hair shaft and hatch in 5-6 days
c) Mycoptes musculinum and Radfordia affinis are difficult to distinguish using light microscopy
d) Chronic acariasis may induce elevated serum IgE and lead to secondary amyloidosis

A

d) Chronic acariasis may induce elevated serum IgE and lead to secondary amyloidosis

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6
Q

Which of the following species is used as a model for decompression sickness, also known as “the Bends”?

a) Neotoma spp. (Pack Rat)
b) Dipodomys spp. (Kangaroo rat)
c) Peromyscus spp. (Deer mice)
d) Oryzomys spp. (Rice rat)

A

b. Dipodomys spp. (Kangaroo rat)

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7
Q

Which of the following mouse strains have a high incidence of thymic lymphoma?

a) AKR and Balb/c
b) 129 and AKR
c) C58 and Balb/c
d) 129 and scid

A

b) 129 and AKR

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8
Q

Which of the following anesthetic agents has the narrowest safety margin in adult zebrafish?

a) Tricaine methanesulfanate
b) Lidocaine hydrochloride
c) Gradual cooling
d) Metomidate hydrochloride

A

b) Lidocaine hydrochloride

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9
Q

Which of the following pathogens of Danio rerio is phylogenetically similar, or analogous, to the etiologic agent that causes encephalitozoonosis in Oryctolagus cuniculus?

a) Psuedoloma neurophilia
b) Pseudocapillaria tomentosa
c) Mycobacteria marinum
d) Piscinoodinium pillulare

A

a) Pseudoloma neurophilia

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10
Q

Your are the attending veterinarian of a facility containing a closed colony of rheses macaques and squirrel monkeys. Researchers at your institution have received a large research grant using marmosets. Despite being housed in separate holding rooms, what concern do you have regarding the incorporation of this new species into your primate facility?

a) Marmosets are extremely susceptible and become acutely ill caused by Macacine herpesvirus 1 contracted via fomite transmission
b) Marmosets asymptomatically carry Callitrichinae herpesvirus 3, which can cause acute and lethal disease in macaques if there is an inadvertent exposure
c) Squirrel monkeys asymptomatically carry Saimiriine herpesvirus 1, which can cause acute and lethal disease in marmosets if there is an inadvertent exposure
d) Macaques asymptomatically carry Cercopithecine herpesvirus 9, which can cause acute and lethal disease in marmosets if there is an inadvertent exposure

A

c) Squirrel monkeys asymptomatically carry Saimiriine herpesvirus 1, which can cause acute and lethal disease in marmosets if there is an inadvertent exposure.

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11
Q

Which of the following disinfectants or class of disinfectants is NOT considered a denaturant?

a) Alcohol
b) Benzalkonium chloride
c) Chlorine dioxide
d) Phenolics

A

c) chlorine dioxide

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12
Q

When considering setting per diem rates, which of the following is considered an INDIRECT expense?

a) Depreciation of equipment
b) Labor wages
c) Labor benefits
d) Animal food and bedding

A

a) Depreciation of equipment

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13
Q

Which of the following is TRUE regarding the use of acidified water sources of research rodents?

a) water a pH of 4.5 kills Pseudomonas aeruginosa
b) water consumption in mice is not affected until a pH of water is below 1.5
c) chlorine, hydrochloric acid, tetracycline, and sulfuric acid have been used to reduce bacterial burden in source water
d) pipes or components made of brass, copper, or stainless steel without molybdenum are all resistant to the corrosive nature of acidified water

A

c) chlorine, hydrochloric acid, tetracycline, and sulfuric acid have been used to reduce bacterial burden in source water

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14
Q

Which of the following is FALSE regarding C-type fibers that make up nociceptive neurons?

a) the majority of peripheral nociceptive fibers are comprised of c-type fibers
b) c-type fibers are thinly myelinated and transmit noxious and innocuous stimuli from visceral organs
c) repetitive c fiber stimulation can cause “windup” or increased central sensitization
d) c-type fibers have slow conduction velocities of 0,5-2.0 m/s.

A

b) c-type fibers are thinly myelinated and transmit noxious and innocuous stimuli from visceral organs

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15
Q

Which of the following is TRUE regarding Murine Astrovirus infection in mice?

a) only immunocompromised mice are susceptible to murine astrovirus infection
b) murine astrovirus causes no clinical disease: however, the effects on innate and adaptive immune responses warrant further evaluation
c) RT-PCR has been shown to be successful in detecting murine astrovirus in fecal samples, but not in exhaust air samples
d) murine astrovirus is not effectively transmitted to sentinels through soiled bedding

A

b) murine astrovirus causes no clinical disease: however, the effects on innate and adaptive immune responses warrant further evaluation

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16
Q

The syrian hamster serves as important model of both dilatative and hypertrophic cardiomyopathy. Which of the following is NOT a cardiomyopathic syrian hamster line?

a) UMX-7.1
b) BIO TO-2
c) BIO 53.58
d) BIO 2.4

A

d) BIO 2.4

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17
Q

Which of the following have the highest incidence of chronic progressive nephrosis?

a) male F-344 rats
b) female Sprague-Dawley rats
c) male Wistar rats
d) female Long-Evan rats

A

a) male F-344 rats

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18
Q

Which of the following is NOT a common clinical presentation associated with Shigella sp. infection in macaques?

a) No clinical signs (asymptomatic carrier)
b) bloody diarrhea
c) gingivitis or periodontal disease
d) jaundice

A

d) jaundice

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19
Q

All of the following are live feeds commonly fed to zebrafish except?

a) rotifers
b) artemia
c) paramecium
d) piscinoodinium

A

d) piscinoodinium

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20
Q

Your newest veterinary technician has been in your facility performing vet tech duties for 6 months and is interested in obtaining their LAT certification. They have an associate’s degree in veterinary technology and have 3 years of experience in small animal practice prior to coming to your facility. In how long will they be eligible to take the LAT?

a) they are already eligible
b) 12 months
c) 6 months
d) 18 months

A

b) 12 months

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21
Q

Which of the following species should NOT be picked up by the tail, as they will often spin resulting in degloving injuries of the tail?

a) Peromyscus leucopus
b) Rattus norvegicus
c) Sigmodon hispidus
d) Cynomys ludovidianus

A

c) Sigmodon hispidus

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22
Q

Which of the following is an inbred guinea pig strain?

a) Strain 2
b) IAF Hairless
c) Strain 15
d) Albino Hartley

A

a) Strain 2

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23
Q

Which of the following is the most significant viral agent of acquired immunodeficiency in captive macaques?

a) Simian immunodeficiency virus of macaques
b) Simian retrovirus
c) Simian T-cell leukemia virus
d) Simian hemorrhagic fever virus

A

b) Simian retrovirus

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24
Q

Which of the following species is highly sensitive to xylazine, such that it requires one-tenth of less of that typically administered to other mammalian species?

a) ruminants
b) dogs
c) horses
d) rabbits

A

a) ruminants

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25
Q

What is the temperature range at which autoclaves that use steam under pressure sterilize equipment?

a) 200-220 F
b) 175-200 F
c) 230-250 F
d) 250- 270 F

A

d) 250- 270 F

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26
Q

Which of the following components of a diet is significantly affected by autoclaving?

a) thiamin
b) vitamin K
c) iron
d) calcium

A

a) thiamin

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27
Q

The use of vaporized hydrogen peroxide (VHP) is increasing in biomedical research facilities. Which of the following is an inaccurate characterization of this method?

a) It is a high temperature sterilant
b) VHP decomposes into water and oxygen
c) effectiveness is dependent on environmental moisture
d) VHP is safe to use on electronics, metals, plastics, and elastomers

A

a) it is a high temperature sterilant

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28
Q

Which of the following species is considered a eusocial mammal?

a) Onychomys leucogaster
b) Tursiops truncatus
c) Apis dorsata
d) Heterocephalus glaber

A

d) Heterocephalus glaber

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29
Q

Sterilization indicators should be used to validate that materials have been properly sterilized. To test, validate, and monitor steam sterilization processes, spores of which bacteria are used in this process?

a) Streptocacillus moniliformis
b) Geobacillus stearothermophilus
c) Thermococcus litoralis
d) Truperella pyogenes

A

b) Geobacillus stearothermophilus

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30
Q

An estrodiol-dependent mononuclear leukocyte which is unique to the guinea pig is referred to as this type of cell.

a) contour monocyte
b) kurloff cell
c) howell-jolly cell
d) koch cell

A

b) Kurloff cell

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31
Q

During natural epizootics, the following mouse strain is resistant to severe disease caused by Ectromelia virus:

a) DBA/1
b) A
c) DBA/2
d) C57BL/6

A

d) C57BL/6

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32
Q

Studies of lymphocytic choriomengitis virus in hamsters should be conducted under ABSL-___ conditions.

a) 1
b) 2
c) 3
d) 4

A

c) 3

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33
Q

Acidification of water is a common method for controlling microbial contamination. What is the recommended pH for acidified water?

a) 1.5-2.0
b) 2.0-2.5
c) 2.5-3.0
d) 3.0-3.5

A

c) 2.5-3.0

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34
Q

According to the Guide, what is the minimum floor space required to group house 4 pigs (each weighing 16 kg)?

a) 24 ft2
b) 30 ft2
c) 40 ft2
d) 124 ft2

A

a) 24 ft2

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35
Q

Which of the following is FALSE regarding CITES?

a) the Lacey Act authorized the USFW to protect threatened and endangered animal and plant species and their habitats from extinction
b) The Lacey Act was initially passed in 1900 and falls under the US Department of the Interior
c) The Lacey Act provides regulations for humane transport of animals within, but not into the US
d) CITES regulations covers designated vertebrate and invertebrate animal or plant species, whether alive or dead, and any recognizable part of a designated animal

A

c) The Lacey Act provides regulations for humane transport of animals within, but not into the US

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36
Q

Which of the following is categorized as CITES 1?

a) Macaca silenus
b) Macaca nemestrina
c) Macaca slvanus
d) Macaca nigra

A

a) Macaca silenus

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37
Q

Providing that puppies are maintained as distinct litters in an appropriate enclosure, at what age must they first require individual identification?

a) 8 weeks
b) 12 weeks
c) 16 weeks
d) 20 weeks

A

c) 16 weeks

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38
Q

Within how many days of shipping must a cat be examined by a licensed veterinarian?

a) 10 days
b) 14 days
c) 20 days
d) 21 days

A

a) 10 days

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39
Q

According to the NIH, which of the following would be classified as Dual Research of Concern?

a) Research that includes species covered by both the Animal Welfare Act and Public Health Service Policy
b) Research that may enhance the virulence of the pathogen, make a vaccine less effective, or alter the host range of a pathogen
c) Research at institutions that generate more than 10 liters of culture modified with recombinant DNA and synthetic nucleic acids
d) none of the above

A

b) Research that may enhance the virulence of the pathogen, make a vaccine less effective, or alter the host range of a pathogen

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40
Q

According to GLP regulations, _________ are food and color additives, animal food additives, human and animal drugs, medical devices for human use, biological products, and electronic products, whereas __________ are the animals in the study.

a) test system; test unit
b) test unit; test article
c) test article; test system
d) test material; test experiment

A

c) test article; test system

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41
Q

An IACUC has 10 members. A full committee review meeting is organized and 6 members of the IACUC are present. One of the members present is also the PI of the proposed research project. Out of those 6 members present, 4 vote to approve the research project, the other 2 vote against. Based on the PHS, is this research project approved by the IACUC?

a) The project is not approved because there was not a majority vote of the entire IACUC members
b) The project is approved because there was a majority vote of the quorum present
c) The project is not approved because there is not a quorum present for this business item
d) The project is approved if the veterinarian and nonaffliated member have voted in favor of the project

A

c) The project is not approved because there is not a quorum present for this business term

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42
Q

Which of the following is NOT considered a satellite facilities/study area are those that house _______ for more than ______ hours

a) Canis familiaris: more than 24 hours
b) Mus musculus; more than 24 hours
c) Peromyscus spp.; more than 12 hours
d) Cavia porcellus; more than 12 hours
e) Rattus norvegicus; more than 12 hours

A

e) Rattus norvegicus; more than 12 hours

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43
Q

What is the lowest ambient temperature allowed in an indoor housing facility for cats and dogs intolerant or unacclimated of lower temperature or are sick/ill?

a) 60
b) 65
c) 55
d) 50

A

d) 50

44
Q

According to the Animal Welfare Regulations, what is the maximum amount of time that rabbit primary enclosures can be sanitized and by what means?

a) 7 days, 180F hot water with soap or detergent
b) 14 days, 180F hot water with soap or detergent
c) 21 days, live steam or flame
d) 30 days, live steam or flame

A

d) 30 days, live steam or flame

45
Q

If the IACUC uses subcommittees, how many committee members must be on the subcommittee?

a) 1
b) 2
c) 3
d) 4

A

b) 2

46
Q

Which of the following is true of the required frequency of IACUC’s review activities involving animals?

a) USDA AWR requires review at least annually, the Guide does not set requirements
b) USDA AWR requires review at least every three years, the Guide requires review at least every three years
c) USDA AWR does not specify, the Guide requires review at least annually
d) USDA AWR requires review at least annually, the Guide requires review at least annually

A

a) USDA AWR requires review at least annually, the Guide does not set requirements

47
Q

According to the Guide, animal facility doors should measure _______ and corridors should measure _______

a) 48” x 80” and 6’-8’ in width
b) 42” x 84” and 6’-8’ in width
c) 48” x 80” and 8’-10’ in width
d) 42” x 84” and 8’-10’ in width

A

b) 42”x 84” and 6’-8- in width

48
Q

The amendment of the Animal Welfare Act that officially excluded birds and animals of the genus Rattus and Mus.

a) Pet Theft Act
b) Lab Animal Welfare Act
c) Helms Amendment
d) Lacey Act

A

c) Helms Amendment

49
Q

What date are USDA facility Annual Report forms due on or before?

a) October 1
b) September 30
c) December 1
d) January 1

A

c) December 1

50
Q

According to the Animal Welfare Act Regulations, what is the maximum number of Cavia porcellus within a primary transport container?

a) 5
b) 10
c) 15
d) 20

A

c) 15

51
Q

According to the Animal Welfare Act Regulations, what is the maximum number of adult Beagle dogs that can be shipped by air in one crate within the US?

a) 1
b) 2
c) 3
d) 4

A

a) 1

52
Q

How often must the Attending Veterinarian review an exemption of non-human primates from the environmental enhancement plan?

a) every 2 weeks
b) every 30 days
c) every 31 days
d) every 6 months
e) annually

A

b) every 30 days

53
Q

A six month old beagle bitch must be fed and watered every how many hours while in transport, respectively?

a) 12 hours; 12 hours
b) 12 hours; 24 hours
c) 24 hours; 12 hours
d) 24 hours; 24 hours
e) 36 hours; 12 hours

A

c) 24 hours; 12 hours

54
Q

Which of the following is the smallest space appropriate to house 3 guinea pigs above 350 grams?

a) a cage 6” high with 300 in2 of floor space
b) a cage 7” high with 300 in2 of floor space
c) a cage 6” high with 350 in2 of floor space
d) a cage 7” high with 350 in2 of floor space

A

d) a cage with 7” high with 350 in2 of floor space

55
Q

Which of the following is true of Category 1 institutions according to the Public Health Service Policy?

a) Defined as research facilities at federal agencies, like the CDC
b) Defined as research facilities that receive research funding from NIH
c) Defined as research facilities that are exempt from providing an assurance
d) Defined as research facilities that have been accredited by AAALAC, Int.

A

d) Defined as research facilities that have been accredited by AAALAC, International

56
Q

Which of the following is NOT considered a Group 6 animal according to the Animal Welfare Act regulations?

a) Ateles spp.
b) Brachyteles spp.
c) Theropithecus spp.
d) Lagothrix spp.

A

c) Theropithecus spp.

57
Q

Which of the following is true regarding development of allergies in those working with laboratory animals?

a) the primary allergen in rats is found in fur and has been identified as Rat n 1A and Rat n 1B
b) the primary allergen in mice is found in fur and has been identified as Mus m 1
c) the primary allergen in birds is found in feathers and has not been identified
d) the primary allergen in rabbits is found in fur and has been identified as a glycoprotein

A

d) the primary allergen in rabbits is found in fur and has been identified as a glycoprotein

58
Q

Which of the following is true regarding training responsibilities of institutions?

a) the USDA AWR states that the research facility is responsible for assuring personnel qualifications/training
b) The Guide for the Care and Use of Laboratory Animals states that the research facility is responsible for assuring the personnel qualifications/training
c) The Public Health Service Policy states that the research facility is responsible for assuring personnel qualifications/training
d) Both the USDA AWR and the Guide address training of personnel

A

A) The USDA AWR states that the research facility is responsible for assuring personnel qualifications/training

59
Q

Which of the following is most consistent with the definition of the minimum horizontal distance?

a) The AWR defines the minimum horizontal distance as the diameter or length of the ear tags used for animal identification of dogs
b) The Guide defines the minimum horizontal distance of the primary enclosures for brachiating nonhuman primate species
c) The AWR defines the minimum horizontal distances as the diameter or length of primary enclosure of leopard seals
d) The Guide defines the minimum horizontal distance as the diameter or length of the ear tags used for animal identification of dogs

A

c) The AWR defines the minimum horizontal distances as the diameter or length of primary enclosure of leopard seals

60
Q

Which of the following is INCORRECT about measles in nonhuman primates:

a) it is a Morbillivirus and is reportable
b) it is an alphaherpesvirus and is not reportable
c) spreads rapidly through colonies via the respiratory route
d) it more likely to appear in immunocompromised individuals

A

a) it is a morbillivirus and is reportable

61
Q

Bumblefoot in rodents can be related to all of the following except:

a) wire bottom caging
b) strain of rodent
c) age of rodent
d) toenail length

A

d) toenail length

62
Q

The strain of mouse that loses hearing at 3-5 months of age is:

a) DBA
b) BALB/c
c) A/J
d) CBA

A

c) A/J

63
Q

Which of the following statements is correct?

a) a select agent requires registration with the CDC and/or USDA
b) agents classified as BSL-3 and BSL-4 have vaccines available for protection of workers
c) agents that are studied in an ABSL are problematic only to animals
d) mice with LCMV must be housed under ABSL-3 conditions, but hamsters can be housed under ABSL-2 conditions

A

a) a select agent requires registration with the CDC and/or USDA

64
Q

Which of the following statements is correct?

a) the standard temperature for zebrafish maintenance is 29.5 c
b) the first embryonic cleavage in zebrafish occurs at 1 hour
c) the heart of a zebrafish begins beating at 24 hours post-fertilization (hpf)
d) embryos of zebrafish begin to feed on day 3

A

c) the heart of a zebrafish begins beating at 24 hours post-fertilization (hpf)

65
Q

To be eligible to take the CMAR examination, the following criteria must be met:

a) HS diploma, 5 years of lab animal experience, 5 years of lab animal management experience
b) BS/BA, 5 years lab animal experience, 3 years lab animal management experience
c) AA/AS, 8 years lab animal experience, 4 years lab animal management experience
d) BS/BA, 3 years lab animal experience, 3 years lab animal management experience

A

b) BS/BA, 5 years lab animal experience, 3 years lab animal management experience

66
Q

Which of the following species are covered by the USDA and AWA when used for scientific research?

a) mus musculus
b) peromyscus leucopus
c) coturnix japonica
d) capra hircus

A

b) peromyscus leucopus

67
Q

Common sites for venipuncture in the rabbit include all EXCEPT the following:

a) jugular vein
b) central ear artery
c) marginal ear vein
d) vena cava

A

d) vena cava

68
Q

Which of the following statements is correct in regard to biosafety levels?

a) an eyewash is required in BSL-3 and BSL-4
b) all material being removed from a BSL-3 or BSL-4 must be autoclaved
c) entry into a BSL-4 laboratory requires a positive pressure suit
d) a shower is required upon exit from a BSL-3 and BSL-4 laboratory

A

a) an eyewash is required in BSL-3 and BSL-4

69
Q

An appropriate site/condition for blood collection in a rodent is:

a) alert femoral vein
b) alert jugular vein
c) sedated orbital plexus of mouse
d) unsedated cardiocentesis

A

b) alert jugular vein

70
Q

A transplant tissue or organ from a normal anatomic site in the donor to the normal anatomic site in the recipient is:

a) heterotopic
b) orthotopic
c) an autograft
d) an allograft

A

b) orthotopic

71
Q

The correct dental formula for a rabbit is:

a) 1/1, 0/0, 2/3, 3/3
b) 2/2, 1/1, 3/2, 3/3
c) 2/1, 0/0, 3/2, 2-3/3
d) 2/1, 0/1, 3/2, 2-3/2

A

c) 2/1, 0/0, 3/2, 2-3/3

72
Q

Pain can be difficult to perceive in animals, especially in prey species. Below are some common signs of pain in animals. All of the following combinations are correct EXCEPT:

a) Rodents: decreased activity, abnormal locomotion, piloerection, decreased food consumption
b) Companion animals: increased licking, hiding, hunched posture, panting
c) NHP: self- directed behavior, reluctance to move, aggression
d) Rabbits: hunched posture, teeth grinding, salivation, increased food consumption

A

d) Rabbits: hunched posture, teeth grinding , salivation, increased food consumption

73
Q

A mouse requires how many grams of food and milliliters of water each day?

a) 5-6 g food; 8-9 ml water
b) 4-7 g food; 2-3 ml water
c) 3-5 g food; 6-7 ml water
d) 8-10 g food; 5-8 ml water

A

c) 3-5 g food; 6-7 ml water

74
Q

Syphacia obvelata:

a) can be detected by tape test
b) is only a mouse pathogen
c) has a 16 day life cycle
d) causes severe clinical signs

A

a) can be detected by tape test

75
Q

Which of the following is true?

a) a recombinant inbred strain has been repeatedly backcrossed for 10 or more generations.
b) an inbred strain has an occurrence of a mutation within a strain
c) a congenic inbred strain is a cross between 2 inbred strains followed by brother-sister mating for > 20 generations
d) an advanced intercross line has had nonsibling matings for an F2 of a cross between 2 inbred strains

A

d) an advanced intercross line has had nonsibling matings for an F2 of a cross between 2 inbred strains

76
Q

All of the following are tests to assess pain in mouse research models except:

a) hot plate
b) von frey filament
c) rotarod
d) formalin

A

c) rotarod

77
Q

The following statement is true regarding opioid receptors:

a) kappa receptors are located in the peripheral nerves and are responsible for spinal analgesia
b) Mu-1 receptors are located in the cerebral cortex and are responsible for analgesia
c) Mu-2 receptors are located in the spinal cord and are responsible for respiratory depression
d) Delta receptors are located in the thalamus and are responsible for spinal analgesia

A

b) Mu-1 receptors are located in the cerebral cortex and are responsible for analgesia

78
Q

All of the following agents can cause multiple small foci of hepatic necrosis in mice, EXCEPT:

a) orthopox virus
b) coronavirus
c) C. piliforme
d) K. oyxtoca

A

d) K. oyxtoca

79
Q

Which of the following agents cause hepatic necrosis in rabbits?

a) Francisella tularensis
b) Pastuerella multocida
c) Clostridium spiroforme
d) Lawsonia intracellularis

A

a) Francisella tularensis

80
Q

Diarrhea can be caused in pigs by any of these agents:

a) Bracyspira hyodysenteriae, Lawsonia intracellularis, Salmonella spp., Coronavirus
b) Coronavirus, Erysipelothrix rhusiopathiae, Porcine Circovirus-2, Lawsonia intracellularis
c) Bracyspira hyodysenteriae, Coronavirus, Haemophilus parasuis, Suid herpesvirus 1
d) TGE, Balantidium coli, Mycoplasma suis, Staphylococcus hyicus

A

a) Bracyspira hyodysenteriae, Lawsonia intracellularis, Salmonella spp., Coronavirus

81
Q

Which of the following mouse strains are predisposed to developing seizures:

a) DBA/2
b) SJL
c) FVB
d) NOD

A

c) FVB

82
Q

Reyes Syndrome is characterized by hepatoencephalopathy and fatty degeneration of the viscera. Which of the following have not demonstrated potential as animal models of the disease?

a) BALB/c mice
b) Cavia porcellus
c) SCID mice
d) Mustela putorius furo

A

b) Cavia porcellus

83
Q

Which of the following is the primary reservoir for Simian Hemorrhagic Fever Virus?

a) Macaca fasicularis
b) Chlorocebus sp.
c) Macaca mulatta
d) Erythrocebus patas

A

d) Erythrocebus patas

84
Q

Which of the following is a Polyoma Virus?

a) SHFV
b) Marburg virus
c) Measles virus
d) SV40
e) Kyasanur Forrest Virus

A

d) SV40

85
Q

Noma (cancrum Oris) is the end stage manifestations of which of the following diseases in macaca mulatta?

a) PTLV
b) SRV-1
c) SIV
d) HIV-1

A

b) SRV-1

86
Q

Which of the following is true?

a) monkeypox virus is an orthopoxvirus with a primary aerosol route of transmission and may be carried by Cynomys sp.
b) monkeypox virus is an orthopoxvirus with a primary direct contact route of transmission and may be carried by Fascilurais sp.
c) monkeypoxvirus is an orthopoxvirus which must be handled under ABSL2 conditions if staff are vaccinated.
d) monkeypoxvirus is also referred to as tanapox and new world primates are immune to the disease

A

a) monkeypox virus is an orthopox virus with a primary aerosol route of transmission and may be carried by Cynomys sp.

87
Q

Cardiomyocytes in Macaca fasicularis infected with the parasite Trypanosoma cruzi will contain which life cycle stage?

a) trypomastigote
b) epimastigote
c) amastigote
d) dimastigote

A

c) amastigote

88
Q

Which of the following is true about Lymphocytic Choriomeningitis Virus (LCMV)?

a) LCMV is an arenavirus which is amplified by Mesocricetus auratus and can be transmitted in utero in Mus musculus
b) LCMV is infectious to humans primarily via the percurtaneous route and must be handled under ABSL3 conditions if mice are used in experiments
c) LCMV is a zoonotic Lassa virus; the house mouse (mus musculus) is the recognized natural reservoir host.
d) LCMV id pathogenic to humans and may cause a fatal hemorrhagic fever in Mesocricetus species

A

a) LCMV is an arenavirus which is amplified by Mesocricetus auratus and can be transmitted in utero in Mus musculus

89
Q

The Seldinger Technique is used for which of the following procedures:

a) placing an intrathecal VAP for monitoring flow of cerebral spinal fluid
b) percutaneous catheter for invasive blood pressure monitoring
c) placing a head post in the correct location of the cranial dura
d) cut-down catheter placement into the carotid artery

A

b) percutaneous catheter for invasive blood pressure monitoring

90
Q

Rodent neonates may be euthanized by gradual hypothermia up to what age according to the AVMA:

a) 5 days
b) 11 days
c) 3 days
d) 7 days

A

d) 7 days

91
Q

Which of the following are considered for anesthetizing Cavia porcellus?

a) isoflurane induced breath-holding occurs in this species
b) a toe pinch is a poor indicator of anesthetic depth
c) excessive salivation and lacrimation during induction with isoflurane
d) ketamine and xylazine anesthesia interferes with ischemia-reperfusion studies
e) all of the above

A

e) all of the above

92
Q

At which stage in the perception of pain pathway would the withdrawal reflex occur?

a) modulation
b) transmission
c) transduction
d) nociception
e) projection

A

b) transmission

93
Q

Which of the following is true regarding copper storage disease?

a) Often referred to as Wilson’s disease where copper granules stain green/black within hepatocytes using Rubeanic acid
b) Often referred to as Gilberts Syndrome- recognized models include the Bedlington terrier, white perch, and long evan cinnamon rat
c) Often referred to as Wilson’s disease where copper granules stain green/black outside of hepatocytes using Zhiel Nielson stain
d) Occurs seasonally in sheep and presents as a condition often referred to as ‘grass staggers’.

A

a) Often referred to as Wilson’s disease where copper granules stain green/black within hepatocytes using Rubeanic acid

94
Q

Which of the following immune cell characteristics are associated with an inbred strain of mus musculus which is also a recognized model of Chediak Higashi syndrome?

a) Lacks NK cells
b) Lacks T and B cells
c) Lacks T, B, and NK cells
d) Lacks T cells, normal NK cells

A

a) Lacks NK cells

95
Q

Which of the following is a model used in rabbits that allows for temporary occlusion of a section of bowel for bacterial colonization studies.

a) RITARD
b) Thiry Fistula
c) Thiry-Vella Fistula
d) Watanabe

A

a) RITARD

96
Q

Which of the following are induced ovulators?

a) Carassius auratas and Oryctolagus cuniculus
b) Felis catus and Marmota monax
c) Mystromys albicaudatas and Mustela putorius furo
d) Tamias striatus and Tupala glis

A

b) Felis catus and Marmota monax

97
Q

Which of the following disinfectants are sporicidal in both the liquid and vapor phases?

a) paracetic acid
b) hydrogen peroxide
c) phenolic compounds
d) quaternary ammonium compounds

A

a) peracetic acid

98
Q

Regarding facilities containing active in-vivo research with Herpes B virus; the following are requirements:

a) laboratories should have double HEPA filters on only the exhaust air outlets
b) external windows must be opened from the inside of the laboratory and have a locking mechanism.
c) a PAPR must be used for respiratory protection in areas where animals are used in research or for propagation of virus from stocks.
d) the laboratory must have disinfectant filled traps and drains with a dedicated effluent decontamination system (EDS)

A

d) the laboratory must have disinfectant filled traps and drains with a dedicated effluent decontamination system (EDS)

99
Q

Which of the following is true regarding the husbandry and care of guinea pigs in research:

a) when placed as pairs with a cagemate, Hartley female guinea pigs spent more time in the cooler range of temperatures from 24-30 c, whereas IAF guinea pigs preferred a range of 30-38 c.
b) guinea pigs adapt readily to change in diet and require vitamin c in their diet
c) guinea pigs cages can be cleaned up to every 30 days
d) guinea pigs, unlike other rodents, show no preference to the periphery of the cage

A

a) when placed as pairs with a cagemate, Hartley female guinea pigs spent more time in the cooler range of temperatures from 24-30 c, whereas IAF guinea pigs preferred a range of 30-38 c.

100
Q

Which of the following are true about the detection of fur mites in mice?

a) testing of ivc filters by pcr has been validated
b) direct observation via tape test of ivc filters has been validated
c) pelt exam is less effective than direct observation via tape and fur pluck combined
d) fur mites are effectively transferred by dirty bedding

A

a) testing of ivc filters by pcr has been validated

101
Q

For which of the following species are dust baths recommended as part of their routine husbandry and care?

a) Phodopus campbelli
b) Marmota monax
c) Octodon degu
d) Cricetulus griseus
e) Graphiurus kelleni

A

d) Cricetulus grisues

102
Q

Cage changing intervals of up to 6 weeks has been shown to be appropriate for which of the the following species:

a) gerbils
b) woodchuck
c) guinea pig
d) rabbit

A

a) gerbil

103
Q

Which of the following is NOT a category used in screening of animal tissue for transplantation into human?

a) absolute contraindication
b) relative contraindication
c) treatable microbes
d) unavoidable microbes
e) benign microbes

A

e) benign microbes

104
Q

According to the PHS Guideline on Infectious Disease Issues in Xenotransplantation, specimens and records relating to xenotransplantation into humans should be maintained for how many years?

a) 5 years
b) 25 years
c) 50 years
d) 75 years
e) indefinately

A

c) 50 years

105
Q

A technician working in your facility has been working in laboratory animal facilities for 2 years and 2 months and is interested in obtaining AALAS certification. Which of the following is true regarding this technician’s eligibility for becoming AALAS certified?

a) with a high school diploma or GED, this technician is eligible to take RLAT exam
b) with BA/BS and 3 years of management experience, this technician is eligible to take the CMAR exam.
c) with AA/AS, this technician is eligible to take the LAT exam
d) with BA/BS, this technician is eligible to take the LATG exam

A

c) with AA/AS, this technician is eligible to take the LAT exam

106
Q

Which of the following are accurate regarding diseases in birds?

a) Taenopygia guttata are susceptible to Eastern Equine Encephalitis which is caused by an arbovirus; an alphavirus in the family Togaviridae
b) Taenopygia gutatta succumb to ventricular colonization by Marcrorhabdus ornithogaster, a weakly gram positive staining yeast
c) aging female birds in the Columbidae family develop bone fragility and serve as a validated model of osteoporosis
d) a blood sucking louse of Tupala glis (Ornithonyssus sylvairarum) can cause disease symptoms in humans and poultry

A

b) Taenopygia gutatta succumb to ventricular colonization by Marcrorhabdus ornithogaster- a weakly gram postive staining yeast

107
Q

Which of the following best describes the reproductive characteristics of Macaca mulatta?

a) seasonal breeder, gestation of about 164 days, interbirth interval of 360 days
b) nonseasonal breeder, gestation of about 164 days, interbirth interval of 380 days
c) seasonal breeder, gestation about 185 days, interbirth interval of 360 days
d) nonseasonal breeder, gestation of 185 days, interbirth interval of 360 days

A

a) seasonal breeder, gestation of 164 days, interbirth interval of 360 days

Mock Exams (TL) (2 decks)

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